Bringing the Spotlight to Tau and TDP-43 in Frontotemporal Demen-tia: A Review of Promising Chemical Compounds

Karla Villalobos-Nova, Sebastián Monroy-Moya, Joaquín Maulen-Peñaloza, Gabriela C.M. Pinto, Alberto Cornejo

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva


There is a wide variety of neurodegenerative diseases, among which frontotem-poral dementia stands out. These are the second most frequent cause of dementia in the world and demand the search for an effective treatment. This disease is linked to the abnormal behavior of proteins, which group together to form insoluble aggregates. It has been shown that the tau protein and TDP-43 are the main proteins involved in these pathologies. This article details 11 compounds already used in different neuropatholo-gies, which may serve as potential drugs against these proteins. The mechanism of how most of these molecules inhibited the tau and TDP-43 aggregation process was highlight-ed. Importantly, Curcumin, Proanthocyanidin B2, Oleocanthal, Oleuropein Aglycone, Thionine, and Resveratrol had been reported as direct inhibitors of tau. While 4-amino-quinoline, Dimethoxycurcumin, and Auranofin directly inhibited TDP-43. Epigallocat-echin-3-gallate and Methylene Blue were described as tau and TDP-43 inhibitors. In this review, it is proposed that future research could elucidate the detailed inhibition mechanisms of these compounds to obtain relevant data to advance in treatments search for these coexisting proteins in frontotemporal dementia.

Idioma originalInglés
Páginas (desde-hasta)5903-5924
Número de páginas22
PublicaciónCurrent Medicinal Chemistry
EstadoPublicada - nov. 2022

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Medicina molecular
  • Farmacología
  • Descubrimiento de medicamentos
  • Química orgánica


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