Brain orexin promotes obesity resistance

Catherine Kotz, Joshua Nixon, Tammy Butterick, Claudio Perez-Leighton, Jennifer Teske, Charles Billington

Resultado de la investigación: Article

53 Citas (Scopus)

Resumen

Resistance to obesity is becoming an exception rather than the norm, and understanding mechanisms that lead some to remain lean in spite of an obesigenic environment is critical if we are to find new ways to reverse this trend. Levels of energy intake and physical activity both contribute to body weight management, but it is challenging for most to adopt major long-term changes in either factor. Physical activity outside of formal exercise, also referred to as activity of daily living, and in stricter form, spontaneous physical activity (SPA), may be an attractive modifiable variable for obesity prevention. In this review, we discuss individual variability in SPA and NEAT (nonexercise thermogenesis, or the energy expended by SPA) and its relationship to obesity resistance. The hypothalamic neuropeptide orexin (hypocretin) may play a key role in regulating SPA and NEAT. We discuss how elevated orexin signaling capacity, in the context of a brain network modulating SPA, may play a major role in defining individual variability in SPA and NEAT. Greater activation of this SPA network leads to a lower propensity for fat mass gain and therefore may be an attractive target for obesity prevention and therapy.

Idioma originalEnglish
Páginas (desde-hasta)72-86
Número de páginas15
PublicaciónAnnals of the New York Academy of Sciences
Volumen1264
N.º1
DOI
EstadoPublished - ago 2012

Huella dactilar

Neuropeptides
Brain
Obesity
Chemical activation
Fats
Thermogenesis
Activities of Daily Living
Energy Intake
Body Weight
Orexins
Physical Activity
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Citar esto

Kotz, C., Nixon, J., Butterick, T., Perez-Leighton, C., Teske, J., & Billington, C. (2012). Brain orexin promotes obesity resistance. Annals of the New York Academy of Sciences, 1264(1), 72-86. https://doi.org/10.1111/j.1749-6632.2012.06585.x
Kotz, Catherine ; Nixon, Joshua ; Butterick, Tammy ; Perez-Leighton, Claudio ; Teske, Jennifer ; Billington, Charles. / Brain orexin promotes obesity resistance. En: Annals of the New York Academy of Sciences. 2012 ; Vol. 1264, N.º 1. pp. 72-86.
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Kotz, C, Nixon, J, Butterick, T, Perez-Leighton, C, Teske, J & Billington, C 2012, 'Brain orexin promotes obesity resistance', Annals of the New York Academy of Sciences, vol. 1264, n.º 1, pp. 72-86. https://doi.org/10.1111/j.1749-6632.2012.06585.x

Brain orexin promotes obesity resistance. / Kotz, Catherine; Nixon, Joshua; Butterick, Tammy; Perez-Leighton, Claudio; Teske, Jennifer; Billington, Charles.

En: Annals of the New York Academy of Sciences, Vol. 1264, N.º 1, 08.2012, p. 72-86.

Resultado de la investigación: Article

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Kotz C, Nixon J, Butterick T, Perez-Leighton C, Teske J, Billington C. Brain orexin promotes obesity resistance. Annals of the New York Academy of Sciences. 2012 ago;1264(1):72-86. https://doi.org/10.1111/j.1749-6632.2012.06585.x