Bovine IgG subclasses and fertility of Echinococcus granulosus hydatid cysts

Silke Riesle, María Pía García, Christian Hidalgo, Norbel Galanti, Leonardo Saenz, Rodolfo Paredes

Resultado de la investigación: Article

10 Citas (Scopus)

Resumen

Hydatidosis is an important zoonotic disease of worldwide distribution, causing important health problems to humans and major economical losses in infected livestock. Echinococcus granulosus, the etiological agent of hydatid disease, induces a humoral immune response in the intermediate host (human and herbivorous) against hydatid cyst antigens. Specifically, IgGs are found in the laminar and germinal layers and inside the lumen of fertile and infertile hydatid cysts. In the germinal layer of infertile cysts IgGs are found in an order of magnitude greater than in the germinal layer of fertile cysts; a fraction of those IgGs are associated with high affinity to germinal layer proteins, suggesting their binding to specific parasite antigens. We have previously shown that those immunoglobulins, bound with high affinity to the germinal layer of hydatid cysts, induce apoptosis leading to cyst infertility.In the present work the presence of IgG1 and IgG2 subclasses in the germinal layer of both fertile and infertile hydatid cysts is reported. IgG1 is the most relevant immunoglobulin subclass present in the germinal layer of infertile cysts and bound with high affinity to that parasite structure. Contrarily, though the IgG2 subclass was also found in the germinal and adventitial layers, those immunoglobulins show low affinity to parasite antigens.We propose that the binding of an IgG1 subclass to parasite antigens present in the germinal layer is involved in the mechanism of cyst infertility.

Idioma originalEnglish
Páginas (desde-hasta)125-133
Número de páginas9
PublicaciónVeterinary Parasitology
Volumen205
N.º1-2
DOI
EstadoPublished - 1 ene 2014

Huella dactilar

Echinococcus granulosus
hydatids
Echinococcosis
Fertility
Cysts
Immunoglobulin G
Parasites
cattle
immunoglobulins
antigens
Antigens
Immunoglobulins
parasites
Infertility
Adventitia
echinococcosis
etiological agents
Zoonoses
Livestock
intermediate hosts

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)

Citar esto

Riesle, Silke ; García, María Pía ; Hidalgo, Christian ; Galanti, Norbel ; Saenz, Leonardo ; Paredes, Rodolfo. / Bovine IgG subclasses and fertility of Echinococcus granulosus hydatid cysts. En: Veterinary Parasitology. 2014 ; Vol. 205, N.º 1-2. pp. 125-133.
@article{0c95f2f41ddd40f1b4937584a37c2fdd,
title = "Bovine IgG subclasses and fertility of Echinococcus granulosus hydatid cysts",
abstract = "Hydatidosis is an important zoonotic disease of worldwide distribution, causing important health problems to humans and major economical losses in infected livestock. Echinococcus granulosus, the etiological agent of hydatid disease, induces a humoral immune response in the intermediate host (human and herbivorous) against hydatid cyst antigens. Specifically, IgGs are found in the laminar and germinal layers and inside the lumen of fertile and infertile hydatid cysts. In the germinal layer of infertile cysts IgGs are found in an order of magnitude greater than in the germinal layer of fertile cysts; a fraction of those IgGs are associated with high affinity to germinal layer proteins, suggesting their binding to specific parasite antigens. We have previously shown that those immunoglobulins, bound with high affinity to the germinal layer of hydatid cysts, induce apoptosis leading to cyst infertility.In the present work the presence of IgG1 and IgG2 subclasses in the germinal layer of both fertile and infertile hydatid cysts is reported. IgG1 is the most relevant immunoglobulin subclass present in the germinal layer of infertile cysts and bound with high affinity to that parasite structure. Contrarily, though the IgG2 subclass was also found in the germinal and adventitial layers, those immunoglobulins show low affinity to parasite antigens.We propose that the binding of an IgG1 subclass to parasite antigens present in the germinal layer is involved in the mechanism of cyst infertility.",
keywords = "Cyst fertility, Echinococcus granulosus, IgG subclass",
author = "Silke Riesle and Garc{\'i}a, {Mar{\'i}a P{\'i}a} and Christian Hidalgo and Norbel Galanti and Leonardo Saenz and Rodolfo Paredes",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.vetpar.2014.06.003",
language = "English",
volume = "205",
pages = "125--133",
journal = "Veterinary Parasitology",
issn = "0304-4017",
publisher = "Elsevier",
number = "1-2",

}

Bovine IgG subclasses and fertility of Echinococcus granulosus hydatid cysts. / Riesle, Silke; García, María Pía; Hidalgo, Christian; Galanti, Norbel; Saenz, Leonardo; Paredes, Rodolfo.

En: Veterinary Parasitology, Vol. 205, N.º 1-2, 01.01.2014, p. 125-133.

Resultado de la investigación: Article

TY - JOUR

T1 - Bovine IgG subclasses and fertility of Echinococcus granulosus hydatid cysts

AU - Riesle, Silke

AU - García, María Pía

AU - Hidalgo, Christian

AU - Galanti, Norbel

AU - Saenz, Leonardo

AU - Paredes, Rodolfo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Hydatidosis is an important zoonotic disease of worldwide distribution, causing important health problems to humans and major economical losses in infected livestock. Echinococcus granulosus, the etiological agent of hydatid disease, induces a humoral immune response in the intermediate host (human and herbivorous) against hydatid cyst antigens. Specifically, IgGs are found in the laminar and germinal layers and inside the lumen of fertile and infertile hydatid cysts. In the germinal layer of infertile cysts IgGs are found in an order of magnitude greater than in the germinal layer of fertile cysts; a fraction of those IgGs are associated with high affinity to germinal layer proteins, suggesting their binding to specific parasite antigens. We have previously shown that those immunoglobulins, bound with high affinity to the germinal layer of hydatid cysts, induce apoptosis leading to cyst infertility.In the present work the presence of IgG1 and IgG2 subclasses in the germinal layer of both fertile and infertile hydatid cysts is reported. IgG1 is the most relevant immunoglobulin subclass present in the germinal layer of infertile cysts and bound with high affinity to that parasite structure. Contrarily, though the IgG2 subclass was also found in the germinal and adventitial layers, those immunoglobulins show low affinity to parasite antigens.We propose that the binding of an IgG1 subclass to parasite antigens present in the germinal layer is involved in the mechanism of cyst infertility.

AB - Hydatidosis is an important zoonotic disease of worldwide distribution, causing important health problems to humans and major economical losses in infected livestock. Echinococcus granulosus, the etiological agent of hydatid disease, induces a humoral immune response in the intermediate host (human and herbivorous) against hydatid cyst antigens. Specifically, IgGs are found in the laminar and germinal layers and inside the lumen of fertile and infertile hydatid cysts. In the germinal layer of infertile cysts IgGs are found in an order of magnitude greater than in the germinal layer of fertile cysts; a fraction of those IgGs are associated with high affinity to germinal layer proteins, suggesting their binding to specific parasite antigens. We have previously shown that those immunoglobulins, bound with high affinity to the germinal layer of hydatid cysts, induce apoptosis leading to cyst infertility.In the present work the presence of IgG1 and IgG2 subclasses in the germinal layer of both fertile and infertile hydatid cysts is reported. IgG1 is the most relevant immunoglobulin subclass present in the germinal layer of infertile cysts and bound with high affinity to that parasite structure. Contrarily, though the IgG2 subclass was also found in the germinal and adventitial layers, those immunoglobulins show low affinity to parasite antigens.We propose that the binding of an IgG1 subclass to parasite antigens present in the germinal layer is involved in the mechanism of cyst infertility.

KW - Cyst fertility

KW - Echinococcus granulosus

KW - IgG subclass

UR - http://www.scopus.com/inward/record.url?scp=84906935589&partnerID=8YFLogxK

U2 - 10.1016/j.vetpar.2014.06.003

DO - 10.1016/j.vetpar.2014.06.003

M3 - Article

C2 - 24962125

AN - SCOPUS:84906935589

VL - 205

SP - 125

EP - 133

JO - Veterinary Parasitology

JF - Veterinary Parasitology

SN - 0304-4017

IS - 1-2

ER -