Bookmarking the genome: Maintenance of epigenetic information

Sayyed K. Zaidi, Daniel W. Young, Martin Montecino, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein

Resultado de la investigación: Short survey

55 Citas (Scopus)

Resumen

Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease.

Idioma originalEnglish
Páginas (desde-hasta)18355-18361
Número de páginas7
PublicaciónJournal of Biological Chemistry
Volumen286
N.º21
DOI
EstadoPublished - 27 may 2011

Huella dactilar

Epigenomics
Genes
Genome
Histone Code
Data storage equipment
Small Untranslated RNA
Gene Expression Regulation
Gene Silencing
Cell Lineage
DNA Methylation
Gene expression
Histones
Transcriptional Activation
Machinery
Disease Progression
Chemical activation
Maintenance
Phenotype
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Citar esto

Zaidi, S. K., Young, D. W., Montecino, M., Van Wijnen, A. J., Stein, J. L., Lian, J. B., & Stein, G. S. (2011). Bookmarking the genome: Maintenance of epigenetic information. Journal of Biological Chemistry, 286(21), 18355-18361. https://doi.org/10.1074/jbc.R110.197061
Zaidi, Sayyed K. ; Young, Daniel W. ; Montecino, Martin ; Van Wijnen, Andre J. ; Stein, Janet L. ; Lian, Jane B. ; Stein, Gary S. / Bookmarking the genome : Maintenance of epigenetic information. En: Journal of Biological Chemistry. 2011 ; Vol. 286, N.º 21. pp. 18355-18361.
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Zaidi, SK, Young, DW, Montecino, M, Van Wijnen, AJ, Stein, JL, Lian, JB & Stein, GS 2011, 'Bookmarking the genome: Maintenance of epigenetic information', Journal of Biological Chemistry, vol. 286, n.º 21, pp. 18355-18361. https://doi.org/10.1074/jbc.R110.197061

Bookmarking the genome : Maintenance of epigenetic information. / Zaidi, Sayyed K.; Young, Daniel W.; Montecino, Martin; Van Wijnen, Andre J.; Stein, Janet L.; Lian, Jane B.; Stein, Gary S.

En: Journal of Biological Chemistry, Vol. 286, N.º 21, 27.05.2011, p. 18355-18361.

Resultado de la investigación: Short survey

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AU - Stein, Gary S.

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Zaidi SK, Young DW, Montecino M, Van Wijnen AJ, Stein JL, Lian JB y otros. Bookmarking the genome: Maintenance of epigenetic information. Journal of Biological Chemistry. 2011 may 27;286(21):18355-18361. https://doi.org/10.1074/jbc.R110.197061