Bookmarking the genome: Maintenance of epigenetic information

Sayyed K. Zaidi, Daniel W. Young, Martin Montecino, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein

Resultado de la investigación: Contribución a una revistaEstudio breverevisión exhaustiva

62 Citas (Scopus)

Resumen

Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease.

Idioma originalInglés
Páginas (desde-hasta)18355-18361
Número de páginas7
PublicaciónJournal of Biological Chemistry
Volumen286
N.º21
DOI
EstadoPublicada - 27 may. 2011

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Biología celular

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