Bookmarking target genes in mitosis: A shared epigenetic trait of phenotypic transcription factors and oncogenes?

Sayyed K. Zaidi, Rodrigo A. Grandy, Cesar Lopez-Camacho, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein

Resultado de la investigación: Review article

32 Citas (Scopus)

Resumen

The regulatory information for phenotype, proliferation, and growth of normal and tumor cells must be maintained through genome replication in the S phase and cell division during mitosis. Epigenetic mechanisms that include DNA methylation, posttranslational modifications of histones, selective utilization of histone variants, and inheritable RNA molecules play pivotal roles in maintaining cellular identity through mitotic divisions. Recent studies demonstrate that mitotic occupancy of genes, which are determinants of cell fate, growth, and proliferation, by lineage-restricted transcription factors is a key epigenetic mechanism for retention and transmission of cellular expression memory. Evidence is emerging for the presence of distinct transcriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for reactivation postmitotically reside. Importantly, some oncoproteins are present in mitotic microenvironments where they occupy target genes during mitosis and may contribute to perpetuating the transformed phenotype. We discuss emerging regulatory implications of epigenetically bookmarking genes during mitosis for physiologic control as well as for the onset and progression of cancer.

Idioma originalEnglish
Páginas (desde-hasta)420-425
Número de páginas6
PublicaciónCancer Research
Volumen74
N.º2
DOI
EstadoPublished - 15 ene 2014

Huella dactilar

Oncogenes
Mitosis
Epigenomics
Transcription Factors
Histones
Genes
Phenotype
Oncogene Proteins
DNA Methylation
Post Translational Protein Processing
Growth
S Phase
Cell Division
Neoplasms
Chromosomes
Genome
RNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Citar esto

Zaidi, Sayyed K. ; Grandy, Rodrigo A. ; Lopez-Camacho, Cesar ; Montecino, Martin ; Van Wijnen, Andre J. ; Lian, Jane B. ; Stein, Janet L. ; Stein, Gary S. / Bookmarking target genes in mitosis : A shared epigenetic trait of phenotypic transcription factors and oncogenes?. En: Cancer Research. 2014 ; Vol. 74, N.º 2. pp. 420-425.
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abstract = "The regulatory information for phenotype, proliferation, and growth of normal and tumor cells must be maintained through genome replication in the S phase and cell division during mitosis. Epigenetic mechanisms that include DNA methylation, posttranslational modifications of histones, selective utilization of histone variants, and inheritable RNA molecules play pivotal roles in maintaining cellular identity through mitotic divisions. Recent studies demonstrate that mitotic occupancy of genes, which are determinants of cell fate, growth, and proliferation, by lineage-restricted transcription factors is a key epigenetic mechanism for retention and transmission of cellular expression memory. Evidence is emerging for the presence of distinct transcriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for reactivation postmitotically reside. Importantly, some oncoproteins are present in mitotic microenvironments where they occupy target genes during mitosis and may contribute to perpetuating the transformed phenotype. We discuss emerging regulatory implications of epigenetically bookmarking genes during mitosis for physiologic control as well as for the onset and progression of cancer.",
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Zaidi, SK, Grandy, RA, Lopez-Camacho, C, Montecino, M, Van Wijnen, AJ, Lian, JB, Stein, JL & Stein, GS 2014, 'Bookmarking target genes in mitosis: A shared epigenetic trait of phenotypic transcription factors and oncogenes?', Cancer Research, vol. 74, n.º 2, pp. 420-425. https://doi.org/10.1158/0008-5472.CAN-13-2837

Bookmarking target genes in mitosis : A shared epigenetic trait of phenotypic transcription factors and oncogenes? / Zaidi, Sayyed K.; Grandy, Rodrigo A.; Lopez-Camacho, Cesar; Montecino, Martin; Van Wijnen, Andre J.; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.

En: Cancer Research, Vol. 74, N.º 2, 15.01.2014, p. 420-425.

Resultado de la investigación: Review article

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AU - Stein, Gary S.

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