Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas

J. R. Brightwell, S. L. Riddle, R. A. Eiferman, P. Valenzuela, P. J. Barr, J. P. Merryweather, G. S. Schultz

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

50 Citas (Scopus)


Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epithelial cells of EGF-Neodecadron-treated corneas appeared normal on histologic examination and showed no evidence of hypertrophy or hyperplasia. The EGF-Neodecadron-treated stromal incisions were characterized by new collagen formation and a smaller epithelial cell plug than Neodecadron-treated control corneas. These results suggest that biosynthetic h-EGF, which lacks the immunologic potential of nonhuman proteins, may be effective in accelerating healing of corneal epithelial defects and stromal incisions in patients whose healing is suppressed by treatment with steroids.

Idioma originalInglés
Páginas (desde-hasta)105-110
Número de páginas6
PublicaciónInvestigative Ophthalmology and Visual Science
EstadoPublicada - 1985

Áreas temáticas de ASJC Scopus

  • Oftalmología
  • Sistema sensorial
  • Neurociencia celular y molecular


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