Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas

J. R. Brightwell, S. L. Riddle, R. A. Eiferman, P. Valenzuela, P. J. Barr, J. P. Merryweather, G. S. Schultz

Resultado de la investigación: Article

50 Citas (Scopus)

Resumen

Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epithelial cells of EGF-Neodecadron-treated corneas appeared normal on histologic examination and showed no evidence of hypertrophy or hyperplasia. The EGF-Neodecadron-treated stromal incisions were characterized by new collagen formation and a smaller epithelial cell plug than Neodecadron-treated control corneas. These results suggest that biosynthetic h-EGF, which lacks the immunologic potential of nonhuman proteins, may be effective in accelerating healing of corneal epithelial defects and stromal incisions in patients whose healing is suppressed by treatment with steroids.

Idioma originalEnglish
Páginas (desde-hasta)105-110
Número de páginas6
PublicaciónInvestigative Ophthalmology and Visual Science
Volumen26
N.º1
EstadoPublished - 1985

Huella dactilar

Epidermal Growth Factor
Cornea
Primates
Epithelial Cells
Steroids
Topical Administration
Hypertrophy
Hyperplasia
Regeneration
Collagen
Anti-Bacterial Agents
Proteins
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Citar esto

Brightwell, J. R., Riddle, S. L., Eiferman, R. A., Valenzuela, P., Barr, P. J., Merryweather, J. P., & Schultz, G. S. (1985). Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas. Investigative Ophthalmology and Visual Science, 26(1), 105-110.
Brightwell, J. R. ; Riddle, S. L. ; Eiferman, R. A. ; Valenzuela, P. ; Barr, P. J. ; Merryweather, J. P. ; Schultz, G. S. / Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas. En: Investigative Ophthalmology and Visual Science. 1985 ; Vol. 26, N.º 1. pp. 105-110.
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abstract = "Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epithelial cells of EGF-Neodecadron-treated corneas appeared normal on histologic examination and showed no evidence of hypertrophy or hyperplasia. The EGF-Neodecadron-treated stromal incisions were characterized by new collagen formation and a smaller epithelial cell plug than Neodecadron-treated control corneas. These results suggest that biosynthetic h-EGF, which lacks the immunologic potential of nonhuman proteins, may be effective in accelerating healing of corneal epithelial defects and stromal incisions in patients whose healing is suppressed by treatment with steroids.",
author = "Brightwell, {J. R.} and Riddle, {S. L.} and Eiferman, {R. A.} and P. Valenzuela and Barr, {P. J.} and Merryweather, {J. P.} and Schultz, {G. S.}",
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Brightwell, JR, Riddle, SL, Eiferman, RA, Valenzuela, P, Barr, PJ, Merryweather, JP & Schultz, GS 1985, 'Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas', Investigative Ophthalmology and Visual Science, vol. 26, n.º 1, pp. 105-110.

Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas. / Brightwell, J. R.; Riddle, S. L.; Eiferman, R. A.; Valenzuela, P.; Barr, P. J.; Merryweather, J. P.; Schultz, G. S.

En: Investigative Ophthalmology and Visual Science, Vol. 26, N.º 1, 1985, p. 105-110.

Resultado de la investigación: Article

TY - JOUR

T1 - Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas

AU - Brightwell, J. R.

AU - Riddle, S. L.

AU - Eiferman, R. A.

AU - Valenzuela, P.

AU - Barr, P. J.

AU - Merryweather, J. P.

AU - Schultz, G. S.

PY - 1985

Y1 - 1985

N2 - Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epithelial cells of EGF-Neodecadron-treated corneas appeared normal on histologic examination and showed no evidence of hypertrophy or hyperplasia. The EGF-Neodecadron-treated stromal incisions were characterized by new collagen formation and a smaller epithelial cell plug than Neodecadron-treated control corneas. These results suggest that biosynthetic h-EGF, which lacks the immunologic potential of nonhuman proteins, may be effective in accelerating healing of corneal epithelial defects and stromal incisions in patients whose healing is suppressed by treatment with steroids.

AB - Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epithelial cells of EGF-Neodecadron-treated corneas appeared normal on histologic examination and showed no evidence of hypertrophy or hyperplasia. The EGF-Neodecadron-treated stromal incisions were characterized by new collagen formation and a smaller epithelial cell plug than Neodecadron-treated control corneas. These results suggest that biosynthetic h-EGF, which lacks the immunologic potential of nonhuman proteins, may be effective in accelerating healing of corneal epithelial defects and stromal incisions in patients whose healing is suppressed by treatment with steroids.

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M3 - Article

VL - 26

SP - 105

EP - 110

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 1

ER -

Brightwell JR, Riddle SL, Eiferman RA, Valenzuela P, Barr PJ, Merryweather JP y otros. Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas. Investigative Ophthalmology and Visual Science. 1985;26(1):105-110.