BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model

Esteban Quezada, Claudio Cappelli, Iván Diaz, Nur Jury, Nicholas Wightman, Robert H. Brown, Martín Montecino, Brigitte van Zundert

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Huella

Profundice en los temas de investigación de 'BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model'. En conjunto forman una huella única.

Medicina y ciencias biológicas