Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Daniel Peña-Oyarzun, Roberto Bravo-Sagua, Alexis Diaz-Vega, Larissa Aleman, Mario Chiong, Lorena Garcia, Claudia Bambs, Rodrigo Troncoso, Mariana Cifuentes, Eugenia Morselli, Catterina Ferreccio, Andrew F.G. Quest, Alfredo Criollo, Sergio Lavandero

Resultado de la investigación: Review article

9 Citas (Scopus)

Resumen

Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.

Idioma originalEnglish
Páginas (desde-hasta)61-78
Número de páginas18
PublicaciónFree Radical Biology and Medicine
Volumen124
DOI
EstadoPublished - 20 ago 2018

Huella dactilar

Oxidative stress
Autophagy
Oxidative Stress
Chronic Disease
Type 2 Diabetes Mellitus
Oxidation-Reduction
Cardiovascular Diseases
Obesity
Inflammation
Medical problems
Crosstalk
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Citar esto

Peña-Oyarzun, D., Bravo-Sagua, R., Diaz-Vega, A., Aleman, L., Chiong, M., Garcia, L., ... Lavandero, S. (2018). Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? Free Radical Biology and Medicine, 124, 61-78. https://doi.org/10.1016/j.freeradbiomed.2018.05.084
Peña-Oyarzun, Daniel ; Bravo-Sagua, Roberto ; Diaz-Vega, Alexis ; Aleman, Larissa ; Chiong, Mario ; Garcia, Lorena ; Bambs, Claudia ; Troncoso, Rodrigo ; Cifuentes, Mariana ; Morselli, Eugenia ; Ferreccio, Catterina ; Quest, Andrew F.G. ; Criollo, Alfredo ; Lavandero, Sergio. / Autophagy and oxidative stress in non-communicable diseases : A matter of the inflammatory state?. En: Free Radical Biology and Medicine. 2018 ; Vol. 124. pp. 61-78.
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abstract = "Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.",
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Peña-Oyarzun, D, Bravo-Sagua, R, Diaz-Vega, A, Aleman, L, Chiong, M, Garcia, L, Bambs, C, Troncoso, R, Cifuentes, M, Morselli, E, Ferreccio, C, Quest, AFG, Criollo, A & Lavandero, S 2018, 'Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?', Free Radical Biology and Medicine, vol. 124, pp. 61-78. https://doi.org/10.1016/j.freeradbiomed.2018.05.084

Autophagy and oxidative stress in non-communicable diseases : A matter of the inflammatory state? / Peña-Oyarzun, Daniel; Bravo-Sagua, Roberto; Diaz-Vega, Alexis; Aleman, Larissa; Chiong, Mario; Garcia, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F.G.; Criollo, Alfredo; Lavandero, Sergio.

En: Free Radical Biology and Medicine, Vol. 124, 20.08.2018, p. 61-78.

Resultado de la investigación: Review article

TY - JOUR

T1 - Autophagy and oxidative stress in non-communicable diseases

T2 - A matter of the inflammatory state?

AU - Peña-Oyarzun, Daniel

AU - Bravo-Sagua, Roberto

AU - Diaz-Vega, Alexis

AU - Aleman, Larissa

AU - Chiong, Mario

AU - Garcia, Lorena

AU - Bambs, Claudia

AU - Troncoso, Rodrigo

AU - Cifuentes, Mariana

AU - Morselli, Eugenia

AU - Ferreccio, Catterina

AU - Quest, Andrew F.G.

AU - Criollo, Alfredo

AU - Lavandero, Sergio

PY - 2018/8/20

Y1 - 2018/8/20

N2 - Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.

AB - Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.

KW - Autophagy

KW - Cancer

KW - Cardiovascular diseases

KW - Diabetes mellitus

KW - Inflammation

KW - Non-communicable diseases

KW - Obesity

KW - Oxidative stress

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U2 - 10.1016/j.freeradbiomed.2018.05.084

DO - 10.1016/j.freeradbiomed.2018.05.084

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SP - 61

EP - 78

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

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