TY - JOUR
T1 - Attempts to Programme Ovulation with Exogenous Oestrogens and LH-RH Analogue
AU - Zañartu, Juan
AU - Guiloff, Enrique
AU - Ibarra-Polo, Agustin A.
AU - Aguilera, Eneida
AU - Rosner, Jorge M.
AU - Croxatto, Hector D.
AU - Croxatto, Horacio B.
AU - Coy, David H.
AU - Schally, Andrew V.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1975/6/7
Y1 - 1975/6/7
N2 - An attempt was made to programme ovulation in women on a predetermined day of the menstrual cycle by treatment used to induce ovulation in anovulatory sterility. At laparotomy for elective sterilization the ovaries were observed to assess the occurrence of ruptured follicles and ovulation. Histological analysis of ovaries and endometrium was performed, and ova were recovered from some women. Several regimens were tested but ovulation seldom occurred as planned. Clomiphene citrate, human chorionic gonadotrophin (HCG), synthetic luteinizing hormone releasing hormone (LH-RH), and ethinyl estradiol were ineffective. Human menopausal gonadotrophin followed by HCG was more effective, but multiple ovulations occurred. When one single injection of a potent long-acting LH-RH analogue was given on day 13 of the cycle to 10 women pretreated with ethinyl estradiol signs of recent ovulation were observed on day 15 in seven and on day 16 in two.
AB - An attempt was made to programme ovulation in women on a predetermined day of the menstrual cycle by treatment used to induce ovulation in anovulatory sterility. At laparotomy for elective sterilization the ovaries were observed to assess the occurrence of ruptured follicles and ovulation. Histological analysis of ovaries and endometrium was performed, and ova were recovered from some women. Several regimens were tested but ovulation seldom occurred as planned. Clomiphene citrate, human chorionic gonadotrophin (HCG), synthetic luteinizing hormone releasing hormone (LH-RH), and ethinyl estradiol were ineffective. Human menopausal gonadotrophin followed by HCG was more effective, but multiple ovulations occurred. When one single injection of a potent long-acting LH-RH analogue was given on day 13 of the cycle to 10 women pretreated with ethinyl estradiol signs of recent ovulation were observed on day 15 in seven and on day 16 in two.
UR - http://www.scopus.com/inward/record.url?scp=0016845228&partnerID=8YFLogxK
U2 - 10.1136/bmj.2.5970.527
DO - 10.1136/bmj.2.5970.527
M3 - Article
C2 - 1097034
AN - SCOPUS:0016845228
SN - 0007-1447
VL - 2
SP - 527
EP - 529
JO - British Medical Journal
JF - British Medical Journal
IS - 5970
ER -