Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: Case-parent design

Bárbara Angel, Iván Balic, José Luis Santos, Ethel Codner, Elena Carrasco, Francisco Pérez-Bravo

Resultado de la investigación: Article

6 Citas (Scopus)

Resumen

CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p = 0.028) was observed, possibly due to an overtransmission of the G-T haplotype.

Idioma originalEnglish
PublicaciónDiabetes Research and Clinical Practice
Volumen85
N.º3
DOI
EstadoPublished - 1 sep 2009

Huella dactilar

Chile
Type 1 Diabetes Mellitus
Haplotypes
T-Lymphocytes
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Citar esto

Angel, Bárbara ; Balic, Iván ; Santos, José Luis ; Codner, Ethel ; Carrasco, Elena ; Pérez-Bravo, Francisco. / Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population : Case-parent design. En: Diabetes Research and Clinical Practice. 2009 ; Vol. 85, N.º 3.
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Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population : Case-parent design. / Angel, Bárbara; Balic, Iván; Santos, José Luis; Codner, Ethel; Carrasco, Elena; Pérez-Bravo, Francisco.

En: Diabetes Research and Clinical Practice, Vol. 85, N.º 3, 01.09.2009.

Resultado de la investigación: Article

TY - JOUR

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AU - Balic, Iván

AU - Santos, José Luis

AU - Codner, Ethel

AU - Carrasco, Elena

AU - Pérez-Bravo, Francisco

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KW - Polymorphism

KW - TDT analysis

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