Aspergillus niger catalyzes the synthesis of flavonoids from chalcones

Julio Alarcón, Joel Alderete, Carlos Escobar, Ramiro Araya, Carlos L. Cespedes

Resultado de la investigación: Contribución a una revistaArtículo

7 Citas (Scopus)

Resumen

Flavonoids, which have many biological activities and have been widely used in nature, can be artificially synthesized. However, regioselective cyclization of chalcones is difficult by chemical methods. In this study, we demonstrated that Aspergillus niger is capable of cyclizing chalcones to flavanones, affording a mimic of plant biosynthetic processes. Chalcones 1-6 were biotransformated to the modified chalcones 8-14 and to the flavanones 15-27. The biotransformation showed that enzymatic cyclization and demethylation occurred during the first days of biotransformation; in contrast, hydroxylation is a later process. With a longer culturing time, it is possible to obtain more hydroxylated flavanones with excellent yields.

Idioma originalInglés
Páginas (desde-hasta)160-167
Número de páginas8
PublicaciónBiocatalysis and Biotransformation
Volumen31
N.º4
DOI
EstadoPublicada - 1 ago 2013

Áreas temáticas de ASJC Scopus

  • Biotecnología
  • Catálisis
  • Bioquímica

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