Architectural epigenetics: Mitotic retention of mammalian transcriptional regulatory information

Sayyed K. Zaidi, Daniel W. Young, Martin Montecino, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, Gary S. Stein

Resultado de la investigación: Contribución a una revistaEstudio breverevisión exhaustiva

38 Citas (Scopus)

Resumen

Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotypespecific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.

Idioma originalInglés
Páginas (desde-hasta)4758-4766
Número de páginas9
PublicaciónMolecular and Cellular Biology
Volumen30
N.º20
DOI
EstadoPublicada - oct 2010

Áreas temáticas de ASJC Scopus

  • Biología molecular
  • Biología celular

Huella

Profundice en los temas de investigación de 'Architectural epigenetics: Mitotic retention of mammalian transcriptional regulatory information'. En conjunto forman una huella única.

Citar esto