Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation

Hugo F. Miranda, Viviana Noriega, Ramiro Zepeda, Pilar Zanetta, Josefina Prieto-Rayo, Juan Carlos Prieto, Fernando Sierralta

Resultado de la investigación: Article

8 Citas (Scopus)

Resumen

Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an antidepressant drug, has been suggested as an alternative treatment. In partial sciatic nerve ligation (PSNL) mice, the interaction of gabapentin with nortriptyline was evaluated by the hot plate assay using isobolographic analysis. Results: Gabapentin (3-100 mg/kg, i.p.) or nortriptyline (1-30 mg/kg, i.p.) induced dose-dependent antinociception, with an ED50 of 11.60 ± 0.54 mg/kg for gabapentin and of 5.16 ± 0.21 mg/kg for nortriptyline. The potency of gabapentin and nortriptyline in PSNL mice at 7 and 14 days after ligation was significantly increased (p < 0.05). Coadministration of gabapentin with nortriptyline, at a 1:1 ratio of their ED50, had a synergistic effect, with an interaction index of 0.311 and 0.348 for these mice at 7 and 14 days, respectively. Conclusion: The data showed a synergy in antinociception at a gabapentin-to-nortriptyline ratio of 1:1 in PSNL mice. This finding suggests that this combination could provide a therapeutic alternative that can be used for neuropathic pain management.

Idioma originalEnglish
Páginas (desde-hasta)59-64
Número de páginas6
PublicaciónPharmacology
Volumen95
DOI
EstadoPublished - 19 mar 2015

Huella dactilar

Nortriptyline
Sciatic Nerve
Ligation
Neuralgia
Pain Management
gabapentin
Anticonvulsants
Antidepressive Agents
Therapeutics
Wounds and Injuries

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Citar esto

Miranda, H. F., Noriega, V., Zepeda, R., Zanetta, P., Prieto-Rayo, J., Prieto, J. C., & Sierralta, F. (2015). Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation. Pharmacology, 95, 59-64. https://doi.org/10.1159/000370244
Miranda, Hugo F. ; Noriega, Viviana ; Zepeda, Ramiro ; Zanetta, Pilar ; Prieto-Rayo, Josefina ; Prieto, Juan Carlos ; Sierralta, Fernando. / Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation. En: Pharmacology. 2015 ; Vol. 95. pp. 59-64.
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abstract = "Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an antidepressant drug, has been suggested as an alternative treatment. In partial sciatic nerve ligation (PSNL) mice, the interaction of gabapentin with nortriptyline was evaluated by the hot plate assay using isobolographic analysis. Results: Gabapentin (3-100 mg/kg, i.p.) or nortriptyline (1-30 mg/kg, i.p.) induced dose-dependent antinociception, with an ED50 of 11.60 ± 0.54 mg/kg for gabapentin and of 5.16 ± 0.21 mg/kg for nortriptyline. The potency of gabapentin and nortriptyline in PSNL mice at 7 and 14 days after ligation was significantly increased (p < 0.05). Coadministration of gabapentin with nortriptyline, at a 1:1 ratio of their ED50, had a synergistic effect, with an interaction index of 0.311 and 0.348 for these mice at 7 and 14 days, respectively. Conclusion: The data showed a synergy in antinociception at a gabapentin-to-nortriptyline ratio of 1:1 in PSNL mice. This finding suggests that this combination could provide a therapeutic alternative that can be used for neuropathic pain management.",
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Miranda, HF, Noriega, V, Zepeda, R, Zanetta, P, Prieto-Rayo, J, Prieto, JC & Sierralta, F 2015, 'Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation', Pharmacology, vol. 95, pp. 59-64. https://doi.org/10.1159/000370244

Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation. / Miranda, Hugo F.; Noriega, Viviana; Zepeda, Ramiro; Zanetta, Pilar; Prieto-Rayo, Josefina; Prieto, Juan Carlos; Sierralta, Fernando.

En: Pharmacology, Vol. 95, 19.03.2015, p. 59-64.

Resultado de la investigación: Article

TY - JOUR

T1 - Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation

AU - Miranda, Hugo F.

AU - Noriega, Viviana

AU - Zepeda, Ramiro

AU - Zanetta, Pilar

AU - Prieto-Rayo, Josefina

AU - Prieto, Juan Carlos

AU - Sierralta, Fernando

PY - 2015/3/19

Y1 - 2015/3/19

N2 - Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an antidepressant drug, has been suggested as an alternative treatment. In partial sciatic nerve ligation (PSNL) mice, the interaction of gabapentin with nortriptyline was evaluated by the hot plate assay using isobolographic analysis. Results: Gabapentin (3-100 mg/kg, i.p.) or nortriptyline (1-30 mg/kg, i.p.) induced dose-dependent antinociception, with an ED50 of 11.60 ± 0.54 mg/kg for gabapentin and of 5.16 ± 0.21 mg/kg for nortriptyline. The potency of gabapentin and nortriptyline in PSNL mice at 7 and 14 days after ligation was significantly increased (p < 0.05). Coadministration of gabapentin with nortriptyline, at a 1:1 ratio of their ED50, had a synergistic effect, with an interaction index of 0.311 and 0.348 for these mice at 7 and 14 days, respectively. Conclusion: The data showed a synergy in antinociception at a gabapentin-to-nortriptyline ratio of 1:1 in PSNL mice. This finding suggests that this combination could provide a therapeutic alternative that can be used for neuropathic pain management.

AB - Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an antidepressant drug, has been suggested as an alternative treatment. In partial sciatic nerve ligation (PSNL) mice, the interaction of gabapentin with nortriptyline was evaluated by the hot plate assay using isobolographic analysis. Results: Gabapentin (3-100 mg/kg, i.p.) or nortriptyline (1-30 mg/kg, i.p.) induced dose-dependent antinociception, with an ED50 of 11.60 ± 0.54 mg/kg for gabapentin and of 5.16 ± 0.21 mg/kg for nortriptyline. The potency of gabapentin and nortriptyline in PSNL mice at 7 and 14 days after ligation was significantly increased (p < 0.05). Coadministration of gabapentin with nortriptyline, at a 1:1 ratio of their ED50, had a synergistic effect, with an interaction index of 0.311 and 0.348 for these mice at 7 and 14 days, respectively. Conclusion: The data showed a synergy in antinociception at a gabapentin-to-nortriptyline ratio of 1:1 in PSNL mice. This finding suggests that this combination could provide a therapeutic alternative that can be used for neuropathic pain management.

KW - Hot plate test

KW - Hyperalgesia

KW - Isobolographic analysis

KW - Neuropathic pain

KW - Synergy

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U2 - 10.1159/000370244

DO - 10.1159/000370244

M3 - Article

C2 - 25592638

AN - SCOPUS:84921351903

VL - 95

SP - 59

EP - 64

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

ER -

Miranda HF, Noriega V, Zepeda R, Zanetta P, Prieto-Rayo J, Prieto JC y otros. Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation. Pharmacology. 2015 mar 19;95:59-64. https://doi.org/10.1159/000370244