Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice

Sylvia Arrau, Carla Delporte, Carlos Cartagena, Maité Rodríguez-Díaz, Patricia González, Ximena Silva, Bruce K. Cassels, Hugo F. Miranda

Resultado de la investigación: Article

17 Citas (Scopus)

Resumen

Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3β,16α-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3β,16α-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate. Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively. Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en- 28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium. Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models.

Idioma originalEnglish
Páginas (desde-hasta)164-167
Número de páginas4
PublicaciónJournal of Ethnopharmacology
Volumen133
N.º1
DOI
EstadoPublished - 7 ene 2011

Huella dactilar

Quillaja
Saponins
Analgesics
Ibuprofen
Quillaja Saponins
Tail
Sodium
Triterpenes
Traditional Medicine
Detergents
Esters
Hot Temperature
Acids
quillaic acid

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Citar esto

Arrau, S., Delporte, C., Cartagena, C., Rodríguez-Díaz, M., González, P., Silva, X., ... Miranda, H. F. (2011). Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice. Journal of Ethnopharmacology, 133(1), 164-167. https://doi.org/10.1016/j.jep.2010.09.016
Arrau, Sylvia ; Delporte, Carla ; Cartagena, Carlos ; Rodríguez-Díaz, Maité ; González, Patricia ; Silva, Ximena ; Cassels, Bruce K. ; Miranda, Hugo F. / Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice. En: Journal of Ethnopharmacology. 2011 ; Vol. 133, N.º 1. pp. 164-167.
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abstract = "Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3β,16α-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3β,16α-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate. Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively. Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg{\%}, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en- 28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium. Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models.",
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Arrau, S, Delporte, C, Cartagena, C, Rodríguez-Díaz, M, González, P, Silva, X, Cassels, BK & Miranda, HF 2011, 'Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice', Journal of Ethnopharmacology, vol. 133, n.º 1, pp. 164-167. https://doi.org/10.1016/j.jep.2010.09.016

Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice. / Arrau, Sylvia; Delporte, Carla; Cartagena, Carlos; Rodríguez-Díaz, Maité; González, Patricia; Silva, Ximena; Cassels, Bruce K.; Miranda, Hugo F.

En: Journal of Ethnopharmacology, Vol. 133, N.º 1, 07.01.2011, p. 164-167.

Resultado de la investigación: Article

TY - JOUR

T1 - Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice

AU - Arrau, Sylvia

AU - Delporte, Carla

AU - Cartagena, Carlos

AU - Rodríguez-Díaz, Maité

AU - González, Patricia

AU - Silva, Ximena

AU - Cassels, Bruce K.

AU - Miranda, Hugo F.

PY - 2011/1/7

Y1 - 2011/1/7

N2 - Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3β,16α-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3β,16α-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate. Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively. Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en- 28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium. Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models.

AB - Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3β,16α-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3β,16α-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate. Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively. Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en- 28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium. Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models.

KW - Analgesic activity

KW - Hot-plate assay

KW - Quillaic acid

KW - Quillaic acid derivatives

KW - Quillaja saponaria

KW - Tail-flick assay

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