Antinociception, tolerance, and physical dependence comparison between morphine and tramadol

H. F. Miranda, G. Pinardi

Resultado de la investigación: Article

71 Citas (Scopus)

Resumen

The mechanism of action of tramadol includes the activation of opioid receptors, and the potential ability of the drug to induce tolerance and physical dependence has been evaluated in different animal species and humans. This work was designed to study the involvement of opioid receptors in the antinociceptive activity and the potential ability to develop tolerance, crosstolerance, and/or physical dependence of tramadol. The writhes induced by acetic acid administration was used as algesiometric test. After chronic administration of tramadol, tolerance was evaluated by measuring the antinociceptive activity, and physical dependence was measured by naloxone administration. Morphine was used as drug of comparison. The IP administration of tramadol produced a dose-dependent antinociception with an ED50 value of 7.82 ± 1.16 mg/kg, which was unchanged after chronic administration of either tramadol (39.1 or 100 mg/kg) or morphine (1.05 or 100 mg/kg). By contrast, the ED50 for morphine (0.21 ± 0.08 mg/kg) was significantly reduced only by chronic pretreatment with both doses of morphine (tolerance). Physical dependence was developed only in mice pretreated with morphine, as evidenced by the presence of jumps, wet-dog shakes, tachypnea, piloerection, seizures, diarrhea, and urination after the administration of naloxone (1 mg/kg). These findings suggest that the antinociceptive activity of tramadol in mice is due to activation of opioid and nonopioid mechanisms, and as opposed to morphine, is not likely to induce tolerance and physical dependence. Copyright (C) 1998 Elsevier Science Inc.

Idioma originalEnglish
Páginas (desde-hasta)357-360
Número de páginas4
PublicaciónPharmacology Biochemistry and Behavior
Volumen61
N.º4
DOI
EstadoPublished - 1998

Huella dactilar

Tramadol
Morphine
Aptitude
Opioid Receptors
Naloxone
Piloerection
Chemical activation
Tachypnea
Urination
Acetic Acid
Pharmaceutical Preparations
Opioid Analgesics
Diarrhea
Animals
Seizures
Dogs

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology
  • Biological Psychiatry
  • Clinical Biochemistry
  • Toxicology

Citar esto

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Antinociception, tolerance, and physical dependence comparison between morphine and tramadol. / Miranda, H. F.; Pinardi, G.

En: Pharmacology Biochemistry and Behavior, Vol. 61, N.º 4, 1998, p. 357-360.

Resultado de la investigación: Article

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