Antinociception induced by atorvastatin in different pain models

G. G. Garcia, H. F. Miranda, V. Noriega, F. Sierralta, L. Olavarría, R. J. Zepeda, J. C. Prieto

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

26 Citas (Scopus)

Resumen

Atorvastatin is a statin that inhibits the 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. Several landmark clinical trials have demonstrated the beneficial effects of statin therapy for primary and secondary prevention of cardiovascular disease. It is assumed that the beneficial effects of statin therapy are entirely due to cholesterol reduction. Statins have an additional activity (pleiotropic effect) that has been associated to their anti-inflammatory effects. The aim of the present study was to assess the antinociceptive activity of atorvastatin in five animal pain models. The daily administration of 3-100 mg/kg of atorvastatin by oral gavage induced a significant dose-dependent antinociception in the writhing, tail-flick, orofacial formalin and formalin hind paw tests. However, this antinociceptive activity of atorvastatin was detectable only at high concentrations in the hot plate assay. The data obtained in the present study demonstrates the effect of atorvastatin to reduce nociception and inflammation in different animal pain models.

Idioma originalInglés
Páginas (desde-hasta)125-129
Número de páginas5
PublicaciónPharmacology Biochemistry and Behavior
Volumen100
N.º1
DOI
EstadoPublicada - nov 2011

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Toxicología
  • Farmacología
  • Bioquímica clínica
  • Psiquiatría biológica
  • Psicobiología

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