Antigen engineering in Yeast

Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles

Pablo Valenzuela, Doris Coit, M. Angelica Medina-Selby, Ching H. Kuo, Gary Van Nest, Rae Lyn Burke, Paulina Bull, Mickey S. Urdea, Pierre V. Graves

Resultado de la investigación: Article

66 Citas (Scopus)

Resumen

A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

Idioma originalEnglish
Páginas (desde-hasta)323-326
Número de páginas4
PublicaciónBio/Technology
Volumen3
N.º4
DOI
EstadoPublished - 1 ene 1985

Huella dactilar

Herpes Simplex
Surface Antigens
Antigens
Hepatitis B Surface Antigens
Viruses
Yeast
Hepatitis
Yeasts
Antigen Presentation
Simplexvirus
Hepatitis B virus
Vaccines
Genes

ASJC Scopus subject areas

  • Biotechnology

Citar esto

Valenzuela, P., Coit, D., Medina-Selby, M. A., Kuo, C. H., Van Nest, G., Burke, R. L., ... Graves, P. V. (1985). Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles. Bio/Technology, 3(4), 323-326. https://doi.org/10.1038/nbt0485-323
Valenzuela, Pablo ; Coit, Doris ; Medina-Selby, M. Angelica ; Kuo, Ching H. ; Van Nest, Gary ; Burke, Rae Lyn ; Bull, Paulina ; Urdea, Mickey S. ; Graves, Pierre V. / Antigen engineering in Yeast : Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles. En: Bio/Technology. 1985 ; Vol. 3, N.º 4. pp. 323-326.
@article{b0832023ffdf4638a385dac4abf17544,
title = "Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles",
abstract = "A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.",
author = "Pablo Valenzuela and Doris Coit and Medina-Selby, {M. Angelica} and Kuo, {Ching H.} and {Van Nest}, Gary and Burke, {Rae Lyn} and Paulina Bull and Urdea, {Mickey S.} and Graves, {Pierre V.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1038/nbt0485-323",
language = "English",
volume = "3",
pages = "323--326",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",
number = "4",

}

Valenzuela, P, Coit, D, Medina-Selby, MA, Kuo, CH, Van Nest, G, Burke, RL, Bull, P, Urdea, MS & Graves, PV 1985, 'Antigen engineering in Yeast: Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles', Bio/Technology, vol. 3, n.º 4, pp. 323-326. https://doi.org/10.1038/nbt0485-323

Antigen engineering in Yeast : Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles. / Valenzuela, Pablo; Coit, Doris; Medina-Selby, M. Angelica; Kuo, Ching H.; Van Nest, Gary; Burke, Rae Lyn; Bull, Paulina; Urdea, Mickey S.; Graves, Pierre V.

En: Bio/Technology, Vol. 3, N.º 4, 01.01.1985, p. 323-326.

Resultado de la investigación: Article

TY - JOUR

T1 - Antigen engineering in Yeast

T2 - Synthesis and assembly of hybrid hepatitis b surface antigen-herpes simplex 1 gd particles

AU - Valenzuela, Pablo

AU - Coit, Doris

AU - Medina-Selby, M. Angelica

AU - Kuo, Ching H.

AU - Van Nest, Gary

AU - Burke, Rae Lyn

AU - Bull, Paulina

AU - Urdea, Mickey S.

AU - Graves, Pierre V.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

AB - A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

UR - http://www.scopus.com/inward/record.url?scp=84925287414&partnerID=8YFLogxK

U2 - 10.1038/nbt0485-323

DO - 10.1038/nbt0485-323

M3 - Article

VL - 3

SP - 323

EP - 326

JO - Nature Biotechnology

JF - Nature Biotechnology

SN - 1087-0156

IS - 4

ER -