Anti-inflammatory effects of aloe vera on soy meal-induced intestinal inflammation in zebrafish

K. Fehrmann-Cartes, M. Coronado, A. J. Hernández, M. L. Allende, C. G. Feijoo

Resultado de la investigación: Article

Resumen

Soybean meal is one of the most promising alternatives to replace fishmeal in the aquaculture industry. However, its ingestion triggers an intestinal inflammatory process that compromises fish health and nutrition. Therefore, finding strategies that reduce the deleterious effects of a soy protein-based diet are relevant. In this work we analyzed the effects of an aloe vera (Aloe barbadensis miller, AV) extract on intestinal inflammation and innate immunity of zebrafish by adding it to the water and by supplementing it in a soybean meal-based diet. To search for potential immunomodulatory effects of AV, we tested its effectiveness in two inflammation assays and compared fish fed with either fishmeal or soybean meal-based feed supplemented with AV. Our results show a strong anti-inflammatory effect of AV. Furthermore, while soy-based meal strongly induces the expression of inflammation markers, supplementation with AV reverted this effect. Finally, we show that fish fed with a soy meal diet are highly susceptible to bacterial infection, but that this condition is significantly reduced when the soy meal is supplemented with AV. Our results suggest that AV is a good candidate to be incorporated as an additive in farmed fish diets to facilitate the replacement of fishmeal by soybean meal, maintaining intestinal health.

Idioma originalEnglish
Páginas (desde-hasta)564-573
Número de páginas10
PublicaciónFish and Shellfish Immunology
Volumen95
DOI
EstadoPublished - dic 2019

Huella dactilar

Aloe vera
Nutrition
anti-inflammatory activity
Danio rerio
soybean meal
Anti-Inflammatory Agents
inflammation
fish meal
Fish
soybean
diet
fish feeds
fish
fish nutrition
fish health
farmed fish
Health
Aquaculture
bacterial infections
health and nutrition

ASJC Scopus subject areas

  • Environmental Chemistry
  • Aquatic Science

Citar esto

Fehrmann-Cartes, K. ; Coronado, M. ; Hernández, A. J. ; Allende, M. L. ; Feijoo, C. G. / Anti-inflammatory effects of aloe vera on soy meal-induced intestinal inflammation in zebrafish. En: Fish and Shellfish Immunology. 2019 ; Vol. 95. pp. 564-573.
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abstract = "Soybean meal is one of the most promising alternatives to replace fishmeal in the aquaculture industry. However, its ingestion triggers an intestinal inflammatory process that compromises fish health and nutrition. Therefore, finding strategies that reduce the deleterious effects of a soy protein-based diet are relevant. In this work we analyzed the effects of an aloe vera (Aloe barbadensis miller, AV) extract on intestinal inflammation and innate immunity of zebrafish by adding it to the water and by supplementing it in a soybean meal-based diet. To search for potential immunomodulatory effects of AV, we tested its effectiveness in two inflammation assays and compared fish fed with either fishmeal or soybean meal-based feed supplemented with AV. Our results show a strong anti-inflammatory effect of AV. Furthermore, while soy-based meal strongly induces the expression of inflammation markers, supplementation with AV reverted this effect. Finally, we show that fish fed with a soy meal diet are highly susceptible to bacterial infection, but that this condition is significantly reduced when the soy meal is supplemented with AV. Our results suggest that AV is a good candidate to be incorporated as an additive in farmed fish diets to facilitate the replacement of fishmeal by soybean meal, maintaining intestinal health.",
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Anti-inflammatory effects of aloe vera on soy meal-induced intestinal inflammation in zebrafish. / Fehrmann-Cartes, K.; Coronado, M.; Hernández, A. J.; Allende, M. L.; Feijoo, C. G.

En: Fish and Shellfish Immunology, Vol. 95, 12.2019, p. 564-573.

Resultado de la investigación: Article

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AU - Fehrmann-Cartes, K.

AU - Coronado, M.

AU - Hernández, A. J.

AU - Allende, M. L.

AU - Feijoo, C. G.

PY - 2019/12

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