Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1

H. Miranda, E. Perez, E. Fernandez, F. Rosselot, J. F. Vergara, W. W. Wolstenholme, A. Zuazo

Resultado de la investigación: Article

2 Citas (Scopus)

Resumen

In the neuronal electrically stimulated vas deferens of the rat, the responses evoked by morphine, β-endorphin and catecholamines were studied. The tissue was obtained from rats at various times (7-60 days) following castration, adrenalectomy and castration with adrenalectomy. Pharmacological data are presented which verify an increased reponsiveness to morphine after castration with or without adrenalectomy. In contrast, decreased responsiveness was observed after adrenalectomy alone. Decreased responsiveness of the vas deferens to catecholamines was observed after castration, adrenalectomy and castration with adrenalectomy. Since the responsiveness of the electrically stimulated vas deferens to β-endorphin was unchanged by this treatment (castration, adrenalectomy), it is suggested that the 'ε-opioid' receptor is unaffected by androgens.

Idioma originalEnglish
Páginas (desde-hasta)168-180
Número de páginas13
PublicaciónPharmacology
Volumen30
N.º3
DOI
EstadoPublished - 1985

Huella dactilar

Adrenalectomy
Castration
Opioid Analgesics
Androgens
Catecholamines
Smooth Muscle
Vas Deferens
Endorphins
Morphine
Opioid Receptors
Pharmacology

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Citar esto

Miranda, H., Perez, E., Fernandez, E., Rosselot, F., Vergara, J. F., Wolstenholme, W. W., & Zuazo, A. (1985). Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1. Pharmacology, 30(3), 168-180. https://doi.org/10.1159/000138066
Miranda, H. ; Perez, E. ; Fernandez, E. ; Rosselot, F. ; Vergara, J. F. ; Wolstenholme, W. W. ; Zuazo, A. / Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1. En: Pharmacology. 1985 ; Vol. 30, N.º 3. pp. 168-180.
@article{cc6bad51ee37460481c4653681781e77,
title = "Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1",
abstract = "In the neuronal electrically stimulated vas deferens of the rat, the responses evoked by morphine, β-endorphin and catecholamines were studied. The tissue was obtained from rats at various times (7-60 days) following castration, adrenalectomy and castration with adrenalectomy. Pharmacological data are presented which verify an increased reponsiveness to morphine after castration with or without adrenalectomy. In contrast, decreased responsiveness was observed after adrenalectomy alone. Decreased responsiveness of the vas deferens to catecholamines was observed after castration, adrenalectomy and castration with adrenalectomy. Since the responsiveness of the electrically stimulated vas deferens to β-endorphin was unchanged by this treatment (castration, adrenalectomy), it is suggested that the 'ε-opioid' receptor is unaffected by androgens.",
keywords = "Androgens, Catecholamines, Corticosterone, Opioids, Vas deferens",
author = "H. Miranda and E. Perez and E. Fernandez and F. Rosselot and Vergara, {J. F.} and Wolstenholme, {W. W.} and A. Zuazo",
year = "1985",
doi = "10.1159/000138066",
language = "English",
volume = "30",
pages = "168--180",
journal = "Pharmacology",
issn = "0031-7012",
publisher = "S. Karger AG",
number = "3",

}

Miranda, H, Perez, E, Fernandez, E, Rosselot, F, Vergara, JF, Wolstenholme, WW & Zuazo, A 1985, 'Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1', Pharmacology, vol. 30, n.º 3, pp. 168-180. https://doi.org/10.1159/000138066

Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1. / Miranda, H.; Perez, E.; Fernandez, E.; Rosselot, F.; Vergara, J. F.; Wolstenholme, W. W.; Zuazo, A.

En: Pharmacology, Vol. 30, N.º 3, 1985, p. 168-180.

Resultado de la investigación: Article

TY - JOUR

T1 - Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1

AU - Miranda, H.

AU - Perez, E.

AU - Fernandez, E.

AU - Rosselot, F.

AU - Vergara, J. F.

AU - Wolstenholme, W. W.

AU - Zuazo, A.

PY - 1985

Y1 - 1985

N2 - In the neuronal electrically stimulated vas deferens of the rat, the responses evoked by morphine, β-endorphin and catecholamines were studied. The tissue was obtained from rats at various times (7-60 days) following castration, adrenalectomy and castration with adrenalectomy. Pharmacological data are presented which verify an increased reponsiveness to morphine after castration with or without adrenalectomy. In contrast, decreased responsiveness was observed after adrenalectomy alone. Decreased responsiveness of the vas deferens to catecholamines was observed after castration, adrenalectomy and castration with adrenalectomy. Since the responsiveness of the electrically stimulated vas deferens to β-endorphin was unchanged by this treatment (castration, adrenalectomy), it is suggested that the 'ε-opioid' receptor is unaffected by androgens.

AB - In the neuronal electrically stimulated vas deferens of the rat, the responses evoked by morphine, β-endorphin and catecholamines were studied. The tissue was obtained from rats at various times (7-60 days) following castration, adrenalectomy and castration with adrenalectomy. Pharmacological data are presented which verify an increased reponsiveness to morphine after castration with or without adrenalectomy. In contrast, decreased responsiveness was observed after adrenalectomy alone. Decreased responsiveness of the vas deferens to catecholamines was observed after castration, adrenalectomy and castration with adrenalectomy. Since the responsiveness of the electrically stimulated vas deferens to β-endorphin was unchanged by this treatment (castration, adrenalectomy), it is suggested that the 'ε-opioid' receptor is unaffected by androgens.

KW - Androgens

KW - Catecholamines

KW - Corticosterone

KW - Opioids

KW - Vas deferens

UR - http://www.scopus.com/inward/record.url?scp=0021965737&partnerID=8YFLogxK

U2 - 10.1159/000138066

DO - 10.1159/000138066

M3 - Article

VL - 30

SP - 168

EP - 180

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 3

ER -

Miranda H, Perez E, Fernandez E, Rosselot F, Vergara JF, Wolstenholme WW y otros. Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens1. Pharmacology. 1985;30(3):168-180. https://doi.org/10.1159/000138066