Androgen receptor in human endothelial cells

Verónica Torres-Estay, Daniela V. Carreño, Ignacio F. San Francisco, Paula Sotomayor, Alejandro S. Godoy, Gary J. Smith

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

37 Citas (Scopus)

Resumen

Androgen receptor (AR) is a ligand-inducible transcription factor, and a member of the steroid-thyroid-retinoid receptor superfamily, that mediates the biological effects of androgens in a wide range of physiological and pathological processes. AR expression was identified in vascular cells nearly 20 years ago, and recent research has shown that AR mediates a variety of actions of androgens in endothelial and vascular smooth muscle cells. In this mini-review, we review evidence indicating the importance of AR in human endothelial cell (HUVEC) homeostatic and pathogenic processes. Although a role for AR in the modulation of HUVEC biology is evident, the molecular mechanisms by which AR regulates HUVEC homeostasis and disease processes are not fully understood. Understanding these mechanisms could provide critical insights into the processes of pathogenesis of diseases ranging from cardiovascular disease to cancer that are major causes of human morbidity and mortality.

Idioma originalInglés
Páginas (desde-hasta)R131-R137
PublicaciónJournal of Endocrinology
Volumen224
N.º3
DOI
EstadoPublicada - 2015

Áreas temáticas de ASJC Scopus

  • Endocrinología, diabetes y metabolismo
  • Endocrinología

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