Androgen receptor in human endothelial cells

Verónica Torres-Estay, Daniela V. Carreño, Ignacio F. San Francisco, Paula Sotomayor, Alejandro S. Godoy, Gary J. Smith

Resultado de la investigación: Review article

  • 15 Citas

Resumen

Androgen receptor (AR) is a ligand-inducible transcription factor, and a member of the steroid-thyroid-retinoid receptor superfamily, that mediates the biological effects of androgens in a wide range of physiological and pathological processes. AR expression was identified in vascular cells nearly 20 years ago, and recent research has shown that AR mediates a variety of actions of androgens in endothelial and vascular smooth muscle cells. In this mini-review, we review evidence indicating the importance of AR in human endothelial cell (HUVEC) homeostatic and pathogenic processes. Although a role for AR in the modulation of HUVEC biology is evident, the molecular mechanisms by which AR regulates HUVEC homeostasis and disease processes are not fully understood. Understanding these mechanisms could provide critical insights into the processes of pathogenesis of diseases ranging from cardiovascular disease to cancer that are major causes of human morbidity and mortality.

IdiomaEnglish
PáginasR131-R137
PublicaciónJournal of Endocrinology
Volumen224
Número de edición3
DOI
EstadoPublished - 2015

Huella dactilar

Androgen Receptors
Endothelial Cells
Androgens
Physiological Phenomena
Retinoids
Pathologic Processes
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Thyroid Gland
Homeostasis
Transcription Factors
Cardiovascular Diseases
Steroids
human AR protein
Ligands
Morbidity
Mortality
Research
Neoplasms

Keywords

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism
    • Medicine(all)

    Citar esto

    Torres-Estay, V., Carreño, D. V., San Francisco, I. F., Sotomayor, P., Godoy, A. S., & Smith, G. J. (2015). Androgen receptor in human endothelial cells. Journal of Endocrinology, 224(3), R131-R137. DOI: 10.1530/JOE-14-0611
    Torres-Estay, Verónica ; Carreño, Daniela V. ; San Francisco, Ignacio F. ; Sotomayor, Paula ; Godoy, Alejandro S. ; Smith, Gary J./ Androgen receptor in human endothelial cells. En: Journal of Endocrinology. 2015 ; Vol. 224, N.º 3. pp. R131-R137
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    Torres-Estay, V, Carreño, DV, San Francisco, IF, Sotomayor, P, Godoy, AS & Smith, GJ 2015, 'Androgen receptor in human endothelial cells' Journal of Endocrinology, vol. 224, n.º 3, pp. R131-R137. DOI: 10.1530/JOE-14-0611

    Androgen receptor in human endothelial cells. / Torres-Estay, Verónica; Carreño, Daniela V.; San Francisco, Ignacio F.; Sotomayor, Paula; Godoy, Alejandro S.; Smith, Gary J.

    En: Journal of Endocrinology, Vol. 224, N.º 3, 2015, p. R131-R137.

    Resultado de la investigación: Review article

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    AU - San Francisco,Ignacio F.

    AU - Sotomayor,Paula

    AU - Godoy,Alejandro S.

    AU - Smith,Gary J.

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    Torres-Estay V, Carreño DV, San Francisco IF, Sotomayor P, Godoy AS, Smith GJ. Androgen receptor in human endothelial cells. Journal of Endocrinology. 2015;224(3):R131-R137. Disponible desde, DOI: 10.1530/JOE-14-0611