Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome

Paula Godoy, Delphine Marsac, Elias Stefas, Pablo Ferrer, Nicole D. Tischler, Karla Pino, Pablo Ramdohr, Pablo Vial, Pablo D.T. Valenzuela, Marcela Ferrés, Francisco Veas, Marcelo López-Lastra

Resultado de la investigación: Article

27 Citas (Scopus)

Resumen

Hantavirus cardiopulmonary syndrome (HCPS) is a highly pathogenic emerging disease (40% case fatality rate) caused by New World hantaviruses. Hantavirus infections are transmitted to humans mainly by inhalation of virus-contaminated aerosol particles of rodent excreta and secretions. At present, there are no antiviral drugs or immunotherapeutic agents available for the treatment of hantaviral infection, and the survival rates for infected patients hinge largely on early virus recognition and hospital admission and aggressive pulmonary and hemodynamic support. In this study, we show that Andes virus (ANDV) interacts with human apolipoprotein H (ApoH) and that ApoH-coated magnetic beads or ApoH-coated enzyme-linked immunosorbent assay plates can be used to capture and concentrate the virus from complex biological mixtures, such as serum and urine, allowing it to be detected by both immunological and molecular approaches. In addition, we report that ANDV-antigens and infectious virus are shed in urine of HCPS patients.

Idioma originalEnglish
Páginas (desde-hasta)5046-5055
Número de páginas10
PublicaciónJournal of Virology
Volumen83
N.º10
DOI
EstadoPublished - 1 may 2009

Huella dactilar

Hantavirus
beta 2-Glycoprotein I
apolipoproteins
urine
Urine
antigens
Antigens
viruses
Viruses
antiviral agents
Hantavirus Infections
emerging diseases
excreta
hemodynamics
aerosols
infection
breathing
Aerosols
Complex Mixtures
rodents

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Citar esto

Godoy, P., Marsac, D., Stefas, E., Ferrer, P., Tischler, N. D., Pino, K., ... López-Lastra, M. (2009). Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome. Journal of Virology, 83(10), 5046-5055. https://doi.org/10.1128/JVI.02409-08
Godoy, Paula ; Marsac, Delphine ; Stefas, Elias ; Ferrer, Pablo ; Tischler, Nicole D. ; Pino, Karla ; Ramdohr, Pablo ; Vial, Pablo ; Valenzuela, Pablo D.T. ; Ferrés, Marcela ; Veas, Francisco ; López-Lastra, Marcelo. / Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome. En: Journal of Virology. 2009 ; Vol. 83, N.º 10. pp. 5046-5055.
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abstract = "Hantavirus cardiopulmonary syndrome (HCPS) is a highly pathogenic emerging disease (40{\%} case fatality rate) caused by New World hantaviruses. Hantavirus infections are transmitted to humans mainly by inhalation of virus-contaminated aerosol particles of rodent excreta and secretions. At present, there are no antiviral drugs or immunotherapeutic agents available for the treatment of hantaviral infection, and the survival rates for infected patients hinge largely on early virus recognition and hospital admission and aggressive pulmonary and hemodynamic support. In this study, we show that Andes virus (ANDV) interacts with human apolipoprotein H (ApoH) and that ApoH-coated magnetic beads or ApoH-coated enzyme-linked immunosorbent assay plates can be used to capture and concentrate the virus from complex biological mixtures, such as serum and urine, allowing it to be detected by both immunological and molecular approaches. In addition, we report that ANDV-antigens and infectious virus are shed in urine of HCPS patients.",
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Godoy, P, Marsac, D, Stefas, E, Ferrer, P, Tischler, ND, Pino, K, Ramdohr, P, Vial, P, Valenzuela, PDT, Ferrés, M, Veas, F & López-Lastra, M 2009, 'Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome', Journal of Virology, vol. 83, n.º 10, pp. 5046-5055. https://doi.org/10.1128/JVI.02409-08

Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome. / Godoy, Paula; Marsac, Delphine; Stefas, Elias; Ferrer, Pablo; Tischler, Nicole D.; Pino, Karla; Ramdohr, Pablo; Vial, Pablo; Valenzuela, Pablo D.T.; Ferrés, Marcela; Veas, Francisco; López-Lastra, Marcelo.

En: Journal of Virology, Vol. 83, N.º 10, 01.05.2009, p. 5046-5055.

Resultado de la investigación: Article

TY - JOUR

T1 - Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome

AU - Godoy, Paula

AU - Marsac, Delphine

AU - Stefas, Elias

AU - Ferrer, Pablo

AU - Tischler, Nicole D.

AU - Pino, Karla

AU - Ramdohr, Pablo

AU - Vial, Pablo

AU - Valenzuela, Pablo D.T.

AU - Ferrés, Marcela

AU - Veas, Francisco

AU - López-Lastra, Marcelo

PY - 2009/5/1

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