Analgesic action of clonixin, nifedipine and morphine using the formalin test

D. Bustamante, H. F. Miranda, T. Pelissier, C. Paeile

Resultado de la investigación: Article

25 Citas (Scopus)

Resumen

1. 1. The analgesic effect of C1X, nifedipine, metamizol, indoprofen and morphine in the pain induced by formalin injection (formalin test) was studied. 2. 2. Attempts to demonstrate tolerance to C1X were unsuccessful. 3. 3. In the analgesic test nifedipine and morphine are approximately 10 times more potent than C1X. 4. 4. The present results suggest that the analgesic action of C1X is not mediated by μ1, δ or κ-opioid receptors and the anti-nociceptive effect of nifedipine may be associated with the blockade of the transmembrane inward movements of calcium.

Idioma originalEnglish
Páginas (desde-hasta)319-322
Número de páginas4
PublicaciónGeneral Pharmacology
Volumen20
N.º3
DOI
EstadoPublished - 1989

Huella dactilar

Clonixin
Pain Measurement
Nifedipine
Morphine
Analgesics
Indoprofen
Dipyrone
Opioid Receptors
Formaldehyde
Calcium
Pain
Injections

ASJC Scopus subject areas

  • Pharmacology

Citar esto

Bustamante, D. ; Miranda, H. F. ; Pelissier, T. ; Paeile, C. / Analgesic action of clonixin, nifedipine and morphine using the formalin test. En: General Pharmacology. 1989 ; Vol. 20, N.º 3. pp. 319-322.
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Bustamante, D, Miranda, HF, Pelissier, T & Paeile, C 1989, 'Analgesic action of clonixin, nifedipine and morphine using the formalin test', General Pharmacology, vol. 20, n.º 3, pp. 319-322. https://doi.org/10.1016/0306-3623(89)90266-8

Analgesic action of clonixin, nifedipine and morphine using the formalin test. / Bustamante, D.; Miranda, H. F.; Pelissier, T.; Paeile, C.

En: General Pharmacology, Vol. 20, N.º 3, 1989, p. 319-322.

Resultado de la investigación: Article

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AB - 1. 1. The analgesic effect of C1X, nifedipine, metamizol, indoprofen and morphine in the pain induced by formalin injection (formalin test) was studied. 2. 2. Attempts to demonstrate tolerance to C1X were unsuccessful. 3. 3. In the analgesic test nifedipine and morphine are approximately 10 times more potent than C1X. 4. 4. The present results suggest that the analgesic action of C1X is not mediated by μ1, δ or κ-opioid receptors and the anti-nociceptive effect of nifedipine may be associated with the blockade of the transmembrane inward movements of calcium.

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