The presence of alpha 1-fetoprotein (AFP) was studied in 150 samples of amniotic fluid taken by trans-abdominal amniocenteses in pregnant women between 16 and 43 weeks of gestation, in order to determine if there was any relation between its presence and congenital malformations. The immunodiffusion method, modified by Hernandez et al was used. Quantification was done by radial diffusion. The results showed that if a specimen is contaminated with fetal blood, AFP could be present without malformation. Also some CNS malformations, such as anencephaly, can yield normal levels of AFP in amniotic fluid. Every isoimmunization case studied did have normal levels of AFP. The authors concluded that every high risk pregnant woman should be tested for AFP in amniotic fluid, being sure the sample is not contaminated with blood. Every positive case should be tested again, and if it is still positive, amniography and sonography must be done. Interruption of the pregnancy should be offered as an option.
|Título traducido de la contribución||Alpha-1 fetoprotein in antenatal diagnosis of congenital malformations|
|Número de páginas||22|
|Estado||Publicada - 1978|
|Publicado de forma externa||Sí|
Áreas temáticas de ASJC Scopus
- Medicina (todo)