Advanced glycation end products: New clinical and molecular perspectives

Juan Salazar, Carla Navarro, Ángel Ortega, Manuel Nava, Daniela Morillo, Wheeler Torres, Marlon Hernández, Mayela Cabrera, Lissé Angarita, Rina Ortiz, Maricarmen Chacín, Luis D’marco, Valmore Bermúdez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diag-nosis. The research of complications of DM over the years has allowed the development of numer-ous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF). Hence, this study aimed to establish an update about the molecular mechanisms induced by AGEs during the evolution of chronic complications of DM and describe the newer measurement techniques available, highlighting SAF as a possible tool to measure the risk of developing DM chronic complications.

Idioma originalInglés
Número de artículo7236
PublicaciónInternational Journal of Environmental Research and Public Health
Volumen18
N.º14
DOI
EstadoPublicada - 2 jul 2021

Áreas temáticas de ASJC Scopus

  • Contaminación
  • Salud pública, medioambiental y laboral
  • Salud, toxicología y mutagénesis

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