Adult hippocampal neurogenesis in aging and Alzheimer's disease

Lorena Varela-Nallar, Florencia C. Aranguiz, Ana C. Abbott, Paula G. Slater, Nibaldo C. Inestrosa

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

42 Citas (Scopus)

Resumen

Adult neurogenesis occurs in the subgranular zone of the hippocampal dentate gyrus and the subventricular zone of the lateral ventricles. This process is highly regulated by intrinsic and extrinsic factors, which may control the proliferation and/or maturation of neural progenitor cells. Adult-born neurons are integrated in preexisting networks and may have functional implications for adult brain. Here we attempt to summarize relevant findings concerning the physiological role of adult neurogenesis mainly focused on the subgranular zone, and to discuss the reduced neurogenesis observed during aging and the factors that have been involved in this phenomenon. Finally, we focus on hippocampal neurogenesis in Alzheimer's disease, reviewing animal models of the disease used for the study of this process and the conclusions that have been drawn in this context.

Idioma originalInglés
Páginas (desde-hasta)284-296
Número de páginas13
PublicaciónBirth Defects Research Part C - Embryo Today: Reviews
Volumen90
N.º4
DOI
EstadoPublicada - dic 2010

Áreas temáticas de ASJC Scopus

  • Embriología
  • Biología del desarrollo
  • Medicina (todo)

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