Accuracy of point-of-care serum creatinine devices for detecting patients at risk of contrast-induced nephropathy: A critical overview

Felipe Martínez Lomakin, Catalina Tobar

Resultado de la investigación: Contribución a una revistaArtículo de revisión

7 Citas (Scopus)

Resumen

Contrast-induced nephropathy (CIN) is a common event in hospitals, with reported incidences ranging from 1 to 30%. Patients with underlying kidney disease have an increased risk of developing CIN. Point-of-care (POC) creatinine devices are handheld devices capable of providing quantitative data on a patient's kidney function that could be useful in stratifying preventive measures. This overview aims to synthesize the current evidence on diagnostic accuracy and clinical utility of POC creatinine devices in detecting patients at risk of CIN. Five databases were searched for diagnostic accuracy studies or clinical trials that evaluated the usefulness of POC devices in detecting patients at risk of CIN. Selected articles were critically appraised to assess their individual risk of bias by the use of standard criteria; 13 studies were found that addressed the diagnostic accuracy or clinical utility of POC creatinine devices. Most studies incurred a moderate to high risk of bias. Overall concordance between POC devices and reference standards (clinical laboratory procedures) was found to be moderate, with 95% limits of agreement often lying between -35.4 and +35.4μmol/L (-0.4 and +0.4mg/dL). Concordance was shown to decrease with worsening kidney function. Data on the clinical utility of these devices were limited, but a significant reduction in time to diagnosis was reported in two studies. Overall, POC creatinine devices showed a moderate concordance with standard clinical laboratory creatinine measurements. Several biases could have induced optimism in these estimations. Results obtained from these devices may be unreliable in cases of severe kidney failure. Randomized trials are needed to address the clinical utility of these devices.

Idioma originalInglés
Páginas (desde-hasta)332-343
Número de páginas12
PublicaciónCritical Reviews in Clinical Laboratory Sciences
Volumen51
N.º6
DOI
EstadoPublicada - 1 dic 2014

Áreas temáticas de ASJC Scopus

  • Bioquímica, genética y biología molecular (todo)
  • Bioquímica clínica
  • Bioquímica médica

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