Abortive vampire bat rabies infections in peruvian peridomestic livestock

Julio A. Benavides, Andres Velasco-Villa, Lauren C. Godino, Panayampalli Subbian Satheshkumar, Nino Ruby, Elizabeth Rojas-Paniagua, Carlos Shiva, Nestor Falcon, Daniel G. Streicker

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

Rabies virus infections normally cause universally lethal encephalitis across mammals. However, ‘abortive infections’ which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing antibody titers in 332 unvaccinated livestock of 5 species from a vampire bat rabies endemic region of southern Peru where livestock are the main food source for bats. We detected rabies virus neutralizing antibody titers in 11, 5 and 3.6% of cows, goats and sheep respectively and seropositive animals did not die from rabies within two years after sampling. Seroprevalence was correlated with the number of local livestock rabies mortalities reported one year prior but also one year after sample collection. This suggests that serological status of livestock can indicate the past and future levels of rabies risk to non-reservoir hosts. To our knowledge, this is the first report of anti-rabies antibodies among goats and sheep, suggesting widespread abortive infections among livestock in vampire bat rabies endemic areas. Future research should resolve the within-host biology underlying clearance of rabies infections. Cost-effectiveness analyses are also needed to evaluate whether serological monitoring of livestock can be a viable complement to current monitoring of vampire bat rabies risk based on animal mortalities alone.

Idioma originalInglés
Número de artículoe0008194
PublicaciónPLoS Neglected Tropical Diseases
Volumen14
N.º6
DOI
EstadoPublicada - jun 2020

Áreas temáticas de ASJC Scopus

  • Salud pública, medioambiental y laboral
  • Enfermedades infecciosas

Huella Profundice en los temas de investigación de 'Abortive vampire bat rabies infections in peruvian peridomestic livestock'. En conjunto forman una huella única.

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    Benavides, J. A., Velasco-Villa, A., Godino, L. C., Satheshkumar, P. S., Ruby, N., Rojas-Paniagua, E., Shiva, C., Falcon, N., & Streicker, D. G. (2020). Abortive vampire bat rabies infections in peruvian peridomestic livestock. PLoS Neglected Tropical Diseases, 14(6), [e0008194]. https://doi.org/10.1371/journal.pntd.0008194