Resumen
Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections. In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 685-704 |
| Número de páginas | 20 |
| Publicación | Virulence |
| Volumen | 8 |
| N.º | 6 |
| DOI | |
| Estado | Published - 18 ago 2017 |
Huella dactilar
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Microbiology (medical)
- Infectious Diseases
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Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection. / González, Andrea E.; Lay, Margarita K.; Jara, Evelyn L.; Espinoza, Janyra A.; Gómez, Roberto S.; Soto, Jorge; Rivera, Claudia A.; Abarca, Katia; Bueno, Susan M.; Riedel, Claudia A.; Kalergis, Alexis M.
En: Virulence, Vol. 8, N.º 6, 18.08.2017, p. 685-704.Resultado de la investigación: Review article
TY - JOUR
T1 - Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection
AU - González, Andrea E.
AU - Lay, Margarita K.
AU - Jara, Evelyn L.
AU - Espinoza, Janyra A.
AU - Gómez, Roberto S.
AU - Soto, Jorge
AU - Rivera, Claudia A.
AU - Abarca, Katia
AU - Bueno, Susan M.
AU - Riedel, Claudia A.
AU - Kalergis, Alexis M.
PY - 2017/8/18
Y1 - 2017/8/18
N2 - Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections. In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.
AB - Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections. In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.
KW - Adaptive immunity
KW - HMPV
KW - HRSV
KW - Immunological synapse
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=85045900347&partnerID=8YFLogxK
U2 - 10.1080/21505594.2016.1265725
DO - 10.1080/21505594.2016.1265725
M3 - Review article
C2 - 27911218
AN - SCOPUS:85045900347
VL - 8
SP - 685
EP - 704
JO - Virulence
JF - Virulence
SN - 2150-5594
IS - 6
ER -