Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection

Andrea E. González, Margarita K. Lay, Evelyn L. Jara, Janyra A. Espinoza, Roberto S. Gómez, Jorge Soto, Claudia A. Rivera, Katia Abarca, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

Resultado de la investigación: Review article

2 Citas (Scopus)

Resumen

Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections. In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.

Idioma originalEnglish
Páginas (desde-hasta)685-704
Número de páginas20
PublicaciónVirulence
Volumen8
N.º6
DOI
EstadoPublished - 18 ago 2017

Huella dactilar

Human respiratory syncytial virus
Metapneumovirus
Immunity
Virus Diseases
T-Lymphocytes
B-Lymphocytes
Infection
Immunological Synapses
Viruses
Respiratory Tract Diseases
Adaptive Immunity
Viral Proteins
Virulence Factors
Antiviral Agents
Pneumonia
Epithelial Cells
Cytokines
Research

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Citar esto

González, A. E., Lay, M. K., Jara, E. L., Espinoza, J. A., Gómez, R. S., Soto, J., ... Kalergis, A. M. (2017). Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection. Virulence, 8(6), 685-704. https://doi.org/10.1080/21505594.2016.1265725
González, Andrea E. ; Lay, Margarita K. ; Jara, Evelyn L. ; Espinoza, Janyra A. ; Gómez, Roberto S. ; Soto, Jorge ; Rivera, Claudia A. ; Abarca, Katia ; Bueno, Susan M. ; Riedel, Claudia A. ; Kalergis, Alexis M. / Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection. En: Virulence. 2017 ; Vol. 8, N.º 6. pp. 685-704.
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abstract = "Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections. In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.",
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González, AE, Lay, MK, Jara, EL, Espinoza, JA, Gómez, RS, Soto, J, Rivera, CA, Abarca, K, Bueno, SM, Riedel, CA & Kalergis, AM 2017, 'Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection', Virulence, vol. 8, n.º 6, pp. 685-704. https://doi.org/10.1080/21505594.2016.1265725

Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection. / González, Andrea E.; Lay, Margarita K.; Jara, Evelyn L.; Espinoza, Janyra A.; Gómez, Roberto S.; Soto, Jorge; Rivera, Claudia A.; Abarca, Katia; Bueno, Susan M.; Riedel, Claudia A.; Kalergis, Alexis M.

En: Virulence, Vol. 8, N.º 6, 18.08.2017, p. 685-704.

Resultado de la investigación: Review article

TY - JOUR

T1 - Aberrant T cell immunity triggered by human respiratory syncytial virus and human metapneumovirus infection

AU - González, Andrea E.

AU - Lay, Margarita K.

AU - Jara, Evelyn L.

AU - Espinoza, Janyra A.

AU - Gómez, Roberto S.

AU - Soto, Jorge

AU - Rivera, Claudia A.

AU - Abarca, Katia

AU - Bueno, Susan M.

AU - Riedel, Claudia A.

AU - Kalergis, Alexis M.

PY - 2017/8/18

Y1 - 2017/8/18

N2 - Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections. In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.

AB - Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections. In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.

KW - Adaptive immunity

KW - HMPV

KW - HRSV

KW - Immunological synapse

KW - T cells

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U2 - 10.1080/21505594.2016.1265725

DO - 10.1080/21505594.2016.1265725

M3 - Review article

C2 - 27911218

AN - SCOPUS:85045900347

VL - 8

SP - 685

EP - 704

JO - Virulence

JF - Virulence

SN - 2150-5594

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ER -