A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins

Won Il Choi; Nazila Kamaly; Lorena Riol-Blanco; In Hyun Lee; Jun Wu; Archana Swami; Cristian Vilos; Basit Yameen; Mikyung Yu; Jinjun Shi; Ira Tabas; Ulrich H. Von Andrian; Sangyong Jon; Omid C. Farokhzad

doi:10.1021/nl502994y

A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins

Won Il Choi, Nazila Kamaly, Lorena Riol-Blanco, In Hyun Lee, Jun Wu, Archana Swami, Cristian Vilos, Basit Yameen, Mikyung Yu, Jinjun Shi, Ira Tabas, Ulrich H. Von Andrian, Sangyong Jon, Omid C. Farokhzad

Facultad Medicina

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37 Citas (Scopus)

Resumen

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

Idioma original	Inglés
Páginas (desde-hasta)	6449-6455
Número de páginas	7
Publicación	Nano Letters
Volumen	14
N.º	11
DOI	https://doi.org/10.1021/nl502994y
Estado	Publicada - 12 nov. 2014

Áreas temáticas de ASJC Scopus

Bioingeniería
Química General
Ciencia de los Materiales General
Física de la materia condensada
Ingeniería mecánica

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10.1021/nl502994y

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title = "A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins",

abstract = "Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.",

keywords = "Nanoparticles, biologics, solvent-free, therapeutic proteins, thermosponge",

author = "Choi, {Won Il} and Nazila Kamaly and Lorena Riol-Blanco and Lee, {In Hyun} and Jun Wu and Archana Swami and Cristian Vilos and Basit Yameen and Mikyung Yu and Jinjun Shi and Ira Tabas and {Von Andrian}, {Ulrich H.} and Sangyong Jon and Farokhzad, {Omid C.}",

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doi = "10.1021/nl502994y",

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T1 - A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins

AU - Choi, Won Il

AU - Kamaly, Nazila

AU - Riol-Blanco, Lorena

AU - Lee, In Hyun

AU - Wu, Jun

AU - Swami, Archana

AU - Vilos, Cristian

AU - Yameen, Basit

AU - Yu, Mikyung

AU - Shi, Jinjun

AU - Tabas, Ira

AU - Von Andrian, Ulrich H.

AU - Jon, Sangyong

AU - Farokhzad, Omid C.

PY - 2014/11/12

Y1 - 2014/11/12

N2 - Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

AB - Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

KW - Nanoparticles

KW - biologics

KW - solvent-free

KW - therapeutic proteins

KW - thermosponge

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DO - 10.1021/nl502994y

M3 - Article

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AN - SCOPUS:84910010660

SN - 1530-6984

VL - 14

SP - 6449

EP - 6455

JO - Nano Letters

JF - Nano Letters

IS - 11

ER -

A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins

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