A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins

Won Il Choi, Nazila Kamaly, Lorena Riol-Blanco, In Hyun Lee, Jun Wu, Archana Swami, Cristian Vilos, Basit Yameen, Mikyung Yu, Jinjun Shi, Ira Tabas, Ulrich H. Von Andrian, Sangyong Jon, Omid C. Farokhzad

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

31 Citas (Scopus)

Resumen

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

Idioma originalInglés
Páginas (desde-hasta)6449-6455
Número de páginas7
PublicaciónNano Letters
Volumen14
N.º11
DOI
EstadoPublicada - 12 nov. 2014

Áreas temáticas de ASJC Scopus

  • Bioingeniería
  • Química (todo)
  • Ciencia de los materiales (todo)
  • Física de la materia condensada
  • Ingeniería mecánica

Huella

Profundice en los temas de investigación de 'A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins'. En conjunto forman una huella única.

Citar esto