A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility

Constanza Martínez-Valdebenito, Jenniffer Angulo, Nicole Le Corre, Claudia Marco, Cecilia Vial, Juan Francisco Miquel, Jaime Cerda, Gregory Mertz, Pablo Vial, Marcelo Lopez-Lastra, Marcela Ferrés

Resultado de la investigación: Article

1 Cita (Scopus)

Resumen

The AndesOrthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2⁻12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.

Idioma originalEnglish
PublicaciónViruses
Volumen11
N.º2
DOI
EstadoPublished - 20 feb 2019
Publicado de forma externa

Huella dactilar

Hantavirus
Virus Diseases
Integrins
Single Nucleotide Polymorphism
Proline
Leucine
Infection
Genotype
Logistic Models
Population

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Citar esto

Martínez-Valdebenito, C., Angulo, J., Le Corre, N., Marco, C., Vial, C., Miquel, J. F., ... Ferrés, M. (2019). A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility. Viruses, 11(2). https://doi.org/10.3390/v11020169
Martínez-Valdebenito, Constanza ; Angulo, Jenniffer ; Le Corre, Nicole ; Marco, Claudia ; Vial, Cecilia ; Miquel, Juan Francisco ; Cerda, Jaime ; Mertz, Gregory ; Vial, Pablo ; Lopez-Lastra, Marcelo ; Ferrés, Marcela. / A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility. En: Viruses. 2019 ; Vol. 11, N.º 2.
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title = "A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility",
abstract = "The AndesOrthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as {"}TT{"} (coding leucine) and {"}CC{"} (coding proline), respectively. TT was present at a rate of 89.2{\%} (66/74) among the first cohort of ANDV cases and at 60{\%} (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4{\%} of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2⁻12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.",
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Martínez-Valdebenito, C, Angulo, J, Le Corre, N, Marco, C, Vial, C, Miquel, JF, Cerda, J, Mertz, G, Vial, P, Lopez-Lastra, M & Ferrés, M 2019, 'A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility', Viruses, vol. 11, n.º 2. https://doi.org/10.3390/v11020169

A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility. / Martínez-Valdebenito, Constanza; Angulo, Jenniffer; Le Corre, Nicole; Marco, Claudia; Vial, Cecilia; Miquel, Juan Francisco; Cerda, Jaime; Mertz, Gregory; Vial, Pablo; Lopez-Lastra, Marcelo; Ferrés, Marcela.

En: Viruses, Vol. 11, N.º 2, 20.02.2019.

Resultado de la investigación: Article

TY - JOUR

T1 - A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility

AU - Martínez-Valdebenito, Constanza

AU - Angulo, Jenniffer

AU - Le Corre, Nicole

AU - Marco, Claudia

AU - Vial, Cecilia

AU - Miquel, Juan Francisco

AU - Cerda, Jaime

AU - Mertz, Gregory

AU - Vial, Pablo

AU - Lopez-Lastra, Marcelo

AU - Ferrés, Marcela

PY - 2019/2/20

Y1 - 2019/2/20

N2 - The AndesOrthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2⁻12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.

AB - The AndesOrthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2⁻12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.

KW - ANDV

KW - Hantavirus

KW - L33P

KW - PSI domain

KW - rs5918

KW - SNP

UR - http://www.scopus.com/inward/record.url?scp=85061970414&partnerID=8YFLogxK

U2 - 10.3390/v11020169

DO - 10.3390/v11020169

M3 - Article

VL - 11

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 2

ER -

Martínez-Valdebenito C, Angulo J, Le Corre N, Marco C, Vial C, Miquel JF y otros. A Single-Nucleotide Polymorphism of α V β₃ Integrin Is Associated with the Andes Virus Infection Susceptibility. Viruses. 2019 feb 20;11(2). https://doi.org/10.3390/v11020169