A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Pablo Cruces; Jaime Retamal; Daniel E. Hurtado; Benjamín Erranz; Pablo Iturrieta; Carlos González; Franco Díaz

doi:10.1186/s13054-020-03197-7

A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Pablo Cruces, Jaime Retamal, Daniel E. Hurtado, Benjamín Erranz, Pablo Iturrieta, Carlos González, Franco Díaz

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99 Citas (Scopus)

Resumen

Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

Idioma original	Inglés
Número de artículo	494
Publicación	Critical Care
Volumen	24
N.º	1
DOI	https://doi.org/10.1186/s13054-020-03197-7
Estado	Publicada - 10 ago. 2020

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title = "A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection",

abstract = "Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.",

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AU - Cruces, Pablo

AU - Retamal, Jaime

AU - Hurtado, Daniel E.

AU - Erranz, Benjamín

AU - Iturrieta, Pablo

AU - González, Carlos

AU - Díaz, Franco

PY - 2020/8/10

Y1 - 2020/8/10

N2 - Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

AB - Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

KW - COVID-19

KW - Lung strain

KW - Mechanical ventilation

KW - P-SILI

KW - SARS-CoV2

KW - Work of breathing

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U2 - 10.1186/s13054-020-03197-7

DO - 10.1186/s13054-020-03197-7

M3 - Review article

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A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

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