A two-rod contraceptive implant system, containing levonorgestrel crystals embedded in a silastic copolymer, has been developed to make insertion and removal times shorter than with the Norplant six-capsule system. The bioequivalence of the two systems has been proved by measurement of levonorgestrel serum levels during the first 3 years of use. After the first week, the serum levels are very similar for the two systems and well above the contraceptive threshold. Insertion and removal times for the two-rod system have been found to be half those required for the Norplant system, while continuation rates and clinical performance have been shown to be virtually identical.
Áreas temáticas de ASJC Scopus
- Endocrinología, diabetes y metabolismo
- Ginecología y obstetricia