A DFT analysis of the strain-induced regioselective[2+2]cycloaddition of benzyne possessing fused four-membered ring

L. R. Domingo, P. Pérez, R. Contreras

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

14 Citas (Scopus)

Resumen

The regioselective [2+2] cycloaddition of a substituted benzyne possessing a fused four-membered ring to a ketene acetal has been theoretically studied. This cycloaddition presents a two-step mechanism that is initiated by the nucleophilic attack to the benzyne to give a zwitterionic intermediate. The analysis performed on the basis of the global and local electrophilicity of reagents correctly explain the observed reactivity and regioselectivity in this system.

Idioma originalInglés
Páginas (desde-hasta)68-73
Número de páginas6
PublicaciónLetters in Organic Chemistry
Volumen2
N.º1
DOI
EstadoPublicada - 1 feb 2005

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Química orgánica

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