LORENA PATRICIA VARELA NALLAR

  • 1432 Citas
  • 22 Índice H
20002019
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Resultado de la investigación 2000 2019

  • 1432 Citas
  • 22 Índice H
  • 33 Article
  • 8 Review article
  • 1 Chapter
  • 1 Comment/debate
Filtro
Article
2019
4 Citas (Scopus)

Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus

Salech, F., Varela-Nallar, L., Arredondo, S. B., Bustamante, D. B., Andaur, G. A., Cisneros, R., Ponce, D. P., Ayala, P., Inestrosa, N. C., Valdés, J. L., Behrens, M. I. & Couve, A., 18 jun 2019, En : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 7, p. 1043-1051 9 p.

Resultado de la investigación: Article

Neurogenesis
Hippocampus
Knockout Mice
Calcitriol Receptors
Stem Cells

PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus

Mardones, M. D., Jorquera, P. V., Herrera-Soto, A., Ampuero, E., Bustos, F. J., van Zundert, B. & Varela-Nallar, L., 1 jul 2019, En : Journal of Chemical Neuroanatomy. 98, p. 117-123 7 p.

Resultado de la investigación: Article

Hippocampus
Neurons
Small Interfering RNA
Dendritic Spines
Neurogenesis

Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling

Arredondo, S. B., Guerrero, F. G., Herrera-Soto, A., Jensen-Flores, J., Bustamante, D. B., Oñate-Ponce, A., Henny, P., Varas-Godoy, M., Inestrosa, N. C. & Varela-Nallar, L., 1 ene 2019, (Accepted/In press) En : Stem Cells.

Resultado de la investigación: Article

Hippocampus
Neurons
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Wnt Signaling Pathway
Neurogenesis
2017
20 Citas (Scopus)

Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice

Bustos, F. J., Ampuero, E., Jury, N., Aguilar, R., Falahi, F., Toledo, J., Ahumada, J., Lata, J., Cubillos, P., Henríquez, B., Guerra, M. V., Stehberg, J., Neve, R. L., Inestrosa, N. C., Wyneken, U., Fuenzalida, M., Härtel, S., Sena-Esteves, M., Varela-Nallar, L., Rots, M. G. y 2 otros, Montecino, M. & Van Zundert, B., 1 dic 2017, En : Brain. 140, 12, p. 3252-3268 17 p.

Resultado de la investigación: Article

Post-Synaptic Density
Epigenomics
Cognition
Alzheimer Disease
Proteins
13 Citas (Scopus)

NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac

Bustos, F. J., Jury, N., Martinez, P., Ampuero, E., Campos, M., Abarzúa, S., Jaramillo, K., Ibing, S., Mardones, M. D., Haensgen, H., Kzhyshkowska, J., Tevy, M. F., Neve, R., Sanhueza, M., Varela-Nallar, L., Montecino, M. & van Zundert, B., 1 dic 2017, En : Journal of Cellular Physiology. 232, 12, p. 3677-3692 16 p.

Resultado de la investigación: Article

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Cyclic AMP Response Element-Binding Protein
N-Methyl-D-Aspartate Receptors
Neurons
Chemical analysis
2016
18 Citas (Scopus)

Frizzled-1 receptor regulates adult hippocampal neurogenesis

Mardones, M. D., Andaur, G. A., Varas-Godoy, M., Henriquez, J. F., Salech, F., Behrens, M. I., Couve, A., Inestrosa, N. C. & Varela-Nallar, L., 15 mar 2016, En : Molecular Brain. 9, 1, 209.

Resultado de la investigación: Article

Frizzled Receptors
Neurogenesis
Neurons
Neural Stem Cells
Dentate Gyrus
58 Citas (Scopus)

Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease

Tapia-Rojas, C., Aranguiz, F., Varela-Nallar, L. & Inestrosa, N. C., 1 ene 2016, En : Brain Pathology. 26, 1, p. 62-74 13 p.

Resultado de la investigación: Article

Neurogenesis
Memory Disorders
Running
Alzheimer Disease
tau Proteins
2015
19 Citas (Scopus)

Andrographolide stimulates neurogenesis in the adult hippocampus

Varela-Nallar, L., Arredondo, S. B., Tapia-Rojas, C., Hancke, J. & Inestrosa, N. C., 2015, En : Neural Plasticity. 2015, 935403.

Resultado de la investigación: Article

Neurogenesis
Hippocampus
Glycogen Synthase Kinase 3
Catenins
Neurons
11 Citas (Scopus)

CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells

Flores-Santibáñez, F., Fernández, D., Meza, D., Tejón, G., Vargas, L., Varela-Nallar, L., Arredondo, S., Guixé, V., Rosemblatt, M., Bono, M. R. & Sauma, D., 1 dic 2015, En : Immunology. 146, 4, p. 582-594 13 p.

Resultado de la investigación: Article

Adenosine
Stem Cells
T-Lymphocytes
Transforming Growth Factors
Immunosuppressive Agents
23 Citas (Scopus)

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

Cisternas, P., Salazar, P., Serrano, F. G., Montecinos-Oliva, C., Arredondo, S. B., Varela-Nallar, L., Barja, S., Vio, C. P., Gomez-Pinilla, F. & Inestrosa, N. C., 1 nov 2015, En : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 11, p. 2379-2390 12 p.

Resultado de la investigación: Article

Neuronal Plasticity
Fructose
Metabolic Brain Diseases
Hippocampus
Learning
4 Citas (Scopus)

The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons

Alfaro, I. E., Varela-Nallar, L., Varas-Godoy, M. & Inestrosa, N. C., 1 jul 2015, En : Molecular and Cellular Neuroscience. 67, p. 22-30 9 p.

Resultado de la investigación: Article

Receptor Tyrosine Kinase-like Orphan Receptors
Dendritic Spines
Receptor Protein-Tyrosine Kinases
Morphogenesis
Neurons
59 Citas (Scopus)

Wnt signalling in neuronal differentiation and development

Inestrosa, N. C. & Varela-Nallar, L., 2015, En : Cell and Tissue Research. 359, 1, p. 215-223 9 p.

Resultado de la investigación: Article

Dendritic Spines
Neurogenesis
Dendrites
Synaptic Transmission
Axons
2014
36 Citas (Scopus)

Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo

Varela-Nallar, L., Rojas-Abalos, M., Abbott, A. C., Moya, E. A., Iturriaga, R. & Inestrosa, N. C., 10 feb 2014, En : Frontiers in Cellular Neuroscience. 8, FEB, 17.

Resultado de la investigación: Article

Catenins
Wnt Signaling Pathway
Neurogenesis
Transgenic Mice
Hippocampus
27 Citas (Scopus)

PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors

Bustos, F. J., Varela-Nallar, L., Campos, M., Henriquez, B., Phillips, M., Opazo, C., Aguayo, L. G., Montecino, M., Constantine-Paton, M., Inestrosa, N. C. & Van Zundert, B., 4 abr 2014, En : PLoS ONE. 9, 4, e94037.

Resultado de la investigación: Article

Neurons
Neuronal Plasticity
Cluster Analysis
neurons
scaffolding proteins
2013
17 Citas (Scopus)

Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons.

Slater, P. G., Ramirez, V. T., Gonzalez-Billault, C., Varela-Nallar, L. & Inestrosa, N. C., 1 ene 2013, En : PLoS ONE. 8, 10

Resultado de la investigación: Article

Frizzled Receptors
Morphogenesis
Neurons
morphogenesis
neurons
25 Citas (Scopus)

Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 Mice

Abbott, A. C., Calderon Toledo, C., Aranguiz, F. C., Inestrosa, N. C. & Varela-Nallar, L., 2013, En : Journal of Alzheimer's Disease. 34, 4, p. 873-885 13 p.

Resultado de la investigación: Article

Neurogenesis
Alzheimer Disease
Cell Proliferation
hyperforin
Neurons
81 Citas (Scopus)

Wnt signaling in the regulation of adult hippocampal neurogenesis

Varela-Nallar, L. & Inestrosa, N. C., 7 jun 2013, En : Frontiers in Cellular Neuroscience. JUNE

Resultado de la investigación: Article

Neurogenesis
Catenins
Wnt Signaling Pathway
Lateral Ventricles
Parahippocampal Gyrus
2012
13 Citas (Scopus)

Frizzled receptors in neurons: From growth cones to the synapse

Varela-Nallar, L., Ramirez, V. T., Gonzalez-Billault, C. & Inestrosa, N. C., jul 2012, En : Cytoskeleton. 69, 7, p. 528-534 7 p.

Resultado de la investigación: Article

Frizzled Receptors
Growth Cones
Wnt Signaling Pathway
Synapses
Wnt Receptors
43 Citas (Scopus)

SIRT1 Regulates Dendritic Development in Hippocampal Neurons

Codocedo, J. F., Allard, C., Godoy, J. A., Varela-Nallar, L. & Inestrosa, N. C., 4 oct 2012, En : PLoS ONE. 7, 10, e47073.

Resultado de la investigación: Article

Neurons
neurons
Neuronal Plasticity
resveratrol
histone deacetylase
22 Citas (Scopus)

Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity

Varela-Nallar, L., Parodi, J., Farías, G. G. & Inestrosa, N. C., abr 2012, En : Neurodegenerative Diseases. 10, 1-4, p. 23-26 4 p.

Resultado de la investigación: Article

Cluster Analysis
Neurons
Synapses
Hippocampus
Dendritic Spines
2011
45 Citas (Scopus)

Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: A possible effect on APP processing

Inestrosa, N. C., Tapia-Rojas, C., Griffith, T. N., Carvajal, F. J., Benito, M. J., Rivera-Dictter, A., Alvarez, A. R., Serrano, F. G., Hancke, J. L., Burgos, P. V., Parodi, J. & Varela-Nallar, L., 12 jul 2011, En : Translational Psychiatry. 1, e20.

Resultado de la investigación: Article

Alzheimer Disease
Phosphorylation
Aptitude
hyperforin
Neuronal Plasticity
3 Citas (Scopus)

The cellular prion protein prevents copper-induced inhibition of P2X 4 receptors

Lorca, R. A., Varela-Nallar, L., Inestrosa, N. C. & Huidobro-Toro, J. P., 2011, En : International Journal of Alzheimer's Disease. 706576.

Resultado de la investigación: Article

Copper
Adenosine Triphosphate
Oocytes
Protein C
Synaptic Transmission
2010
10 Citas (Scopus)

Oxidative damage in lymphocytes of copper smelter workers correlated to higher levels of excreted arsenic

Rios, M., Escobar, J., Varela-Nallar, L., Coddou, C., Nelson, P., Maisey, K., Valdés, D., Aspee, A., Espinosa, V., Rozas, C., Montoya, M., Mandiola, C., Rodríguez, F. E., Acua-Castillo, C., Escobar, A., Fernández, R., Diaz, H., Sandoval, M. & Imarai, M., 1 dic 2010, En : Mediators of Inflammation. 2010, 403830.

Resultado de la investigación: Article

Arsenic
Copper
Lymphocytes
Vitamin E
Population
34 Citas (Scopus)

Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation

Perez de Arce, K., Varela-Nallar, L., Farias, O., Cifuentes, A., Bull, P., Couch, B. A., Koleske, A. J., Inestrosa, N. C. & Alvarez, A. R., 10 mar 2010, En : Journal of Neuroscience. 30, 10, p. 3728-3738 11 p.

Resultado de la investigación: Article

Cluster Analysis
Tyrosine
Phosphorylation
Synapses
Neurons
126 Citas (Scopus)

Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

Varela-Nallar, L., Alfaro, I. E., Serrano, F. G., Parodi, J. & Inestrosa, N. C., 7 dic 2010, En : Proceedings of the National Academy of Sciences of the United States of America. 107, 49, p. 21164-21169 6 p.

Resultado de la investigación: Article

Synapses
Excitatory Postsynaptic Potentials
Spine
Central Nervous System
Neuronal Plasticity
2009
54 Citas (Scopus)

Calcium/calmodulin-dependent protein kinase type IV Is a target gene of the Wnt/β-catenin signaling pathway

Arrázola, M. S., Varela-Nallar, L., Colombres, M., Toledo, E. M., Cruzat, F., Pavez, L., Assar, R., Aravena, A., González, M., Montecino, M., Maass, A., Martínez, S. & Inestrosa, N. C., dic 2009, En : Journal of Cellular Physiology. 221, 3, p. 658-667 10 p.

Resultado de la investigación: Article

Calcium-Calmodulin-Dependent Protein Kinase Type 4
Catenins
Wnt Signaling Pathway
Genes
Neurons
73 Citas (Scopus)

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function

Varela-Nallar, L., Grabowski, C. P., Alfaro, I. E., Alvarez, A. R. & Inestrosa, N. C., 2009, En : Neural Development. 4, 1, 41.

Resultado de la investigación: Article

Wnt Receptors
Wnt Signaling Pathway
Synapses
Cysteine
Cluster Analysis
2008
62 Citas (Scopus)

Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers

Chacón, M. A., Varela-Nallar, L. & Inestrosa, N. C., oct 2008, En : Journal of Cellular Physiology. 217, 1, p. 215-227 13 p.

Resultado de la investigación: Article

Catenins
Wnt Signaling Pathway
Neuroprotective Agents
Oligomers
Toxicity
2007
48 Citas (Scopus)

Synaptotoxicity in Alzheimer's disease: The Wnt signaling pathway as a molecular target

Inestrosa, N. C., Varela-Nallar, L., Grabowski, C. P. & Colombres, M., 2007, En : IUBMB Life. 59, 4-5, p. 316-321 6 p.

Resultado de la investigación: Article

Wnt Signaling Pathway
Alzheimer Disease
Glycogen Synthase Kinase 3
Oligomers
Brain
2006
51 Citas (Scopus)

Induction of cellular prion protein gene expression by copper in neurons

Varela-Nallar, L., Toledo, E. M., Larrondo, L. F., Cabral, A. L. B., Martins, V. R. & Inestrosa, N. C., 1 ene 2006, En : American Journal of Physiology - Cell Physiology. 290, 1

Resultado de la investigación: Article

Copper
Gene Expression
Neurons
Zinc
Clone Cells
17 Citas (Scopus)

The functional links between prion protein and copper

Varela-Nallar, L., Toledo, E. M., Chacón, M. A. & Inestrosa, N. C., 1 ene 2006, En : Biological Research. 39, 1, p. 39-44 6 p.

Resultado de la investigación: Article

prions
Copper
copper
PrPC Proteins
terminal repeat sequences
2005
7 Citas (Scopus)

Fas ligand in the uterus of the non-pregnant mouse induces apoptosis of CD4+ T cells

Imarai, M., Varela-Nallar, L., Figueroa-Gaete, C., González, P., Valdés, D., Velásquez, L., Cárdenas, H. & Maisey, K., 1 jun 2005, En : Journal of Reproductive Immunology. 66, 1, p. 13-32 20 p.

Resultado de la investigación: Article

Fas Ligand Protein
Uterus
Apoptosis
T-Lymphocytes
Oviducts
2000
16 Citas (Scopus)

Expression of intercellular adhesion molecule 1 (ICAM-1) on the human oviductal epithelium and mediation of lymphoid cell adherence

Utreras, E., Ossandon, P., Acuna-Castillo, C., Varela-Nallar, L., Muller, C., Arraztoa, J. A., Cardenas, H. & Imarai, M., 2000, En : Journal of Reproduction and Fertility. 120, 1, p. 115-123 9 p.

Resultado de la investigación: Article

Intercellular Adhesion Molecule-1
Epithelium
Lymphocytes
Oviducts
Major Histocompatibility Complex