LORENA PATRICIA VARELA NALLAR

    • 1371 Citas
    • 22 Índice H
    20002019
    Los cambios que haya realizado en Pure se mostrarán aquí próximamente.

    Resultado de la investigación 2000 2019

    • 1371 Citas
    • 22 Índice H
    • 32 Article
    • 8 Review article
    • 1 Chapter
    • 1 Comment/debate
    2019
    2 Citas (Scopus)

    Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus

    Salech, F., Varela-Nallar, L., Arredondo, S. B., Bustamante, D. B., Andaur, G. A., Cisneros, R., Ponce, D. P., Ayala, P., Inestrosa, N. C., Valdés, J. L., Behrens, M. I. & Couve, A., 18 jun 2019, En : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 7, p. 1043-1051 9 p.

    Resultado de la investigación: Article

    Neurogenesis
    Hippocampus
    Knockout Mice
    Calcitriol Receptors
    Stem Cells

    PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus

    Mardones, M. D., Jorquera, P. V., Herrera-Soto, A., Ampuero, E., Bustos, F. J., van Zundert, B. & Varela-Nallar, L., 1 jul 2019, En : Journal of Chemical Neuroanatomy. 98, p. 117-123 7 p.

    Resultado de la investigación: Article

    Hippocampus
    Neurons
    Small Interfering RNA
    Dendritic Spines
    Neurogenesis
    2017
    19 Citas (Scopus)

    Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice

    Bustos, F. J., Ampuero, E., Jury, N., Aguilar, R., Falahi, F., Toledo, J., Ahumada, J., Lata, J., Cubillos, P., Henríquez, B., Guerra, M. V., Stehberg, J., Neve, R. L., Inestrosa, N. C., Wyneken, U., Fuenzalida, M., Härtel, S., Sena-Esteves, M., Varela-Nallar, L., Rots, M. G. y 2 otros, Montecino, M. & Van Zundert, B., 1 dic 2017, En : Brain. 140, 12, p. 3252-3268 17 p.

    Resultado de la investigación: Article

    Post-Synaptic Density
    Epigenomics
    Cognition
    Alzheimer Disease
    Proteins
    9 Citas (Scopus)

    NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac

    Bustos, F. J., Jury, N., Martinez, P., Ampuero, E., Campos, M., Abarzúa, S., Jaramillo, K., Ibing, S., Mardones, M. D., Haensgen, H., Kzhyshkowska, J., Tevy, M. F., Neve, R., Sanhueza, M., Varela-Nallar, L., Montecino, M. & van Zundert, B., 1 dic 2017, En : Journal of Cellular Physiology. 232, 12, p. 3677-3692 16 p.

    Resultado de la investigación: Article

    Calcium-Calmodulin-Dependent Protein Kinase Type 2
    Cyclic AMP Response Element-Binding Protein
    N-Methyl-D-Aspartate Receptors
    Neurons
    Chemical analysis
    2016
    15 Citas (Scopus)

    Frizzled-1 receptor regulates adult hippocampal neurogenesis

    Mardones, M. D., Andaur, G. A., Varas-Godoy, M., Henriquez, J. F., Salech, F., Behrens, M. I., Couve, A., Inestrosa, N. C. & Varela-Nallar, L., 15 mar 2016, En : Molecular Brain. 9, 1, 209.

    Resultado de la investigación: Article

    Frizzled Receptors
    Neurogenesis
    Neurons
    Neural Stem Cells
    Dentate Gyrus
    54 Citas (Scopus)

    Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease

    Tapia-Rojas, C., Aranguiz, F., Varela-Nallar, L. & Inestrosa, N. C., 1 ene 2016, En : Brain Pathology. 26, 1, p. 62-74 13 p.

    Resultado de la investigación: Article

    Neurogenesis
    Memory Disorders
    Running
    Alzheimer Disease
    tau Proteins
    2015
    16 Citas (Scopus)

    Andrographolide stimulates neurogenesis in the adult hippocampus

    Varela-Nallar, L., Arredondo, S. B., Tapia-Rojas, C., Hancke, J. & Inestrosa, N. C., 2015, En : Neural Plasticity. 2015, 935403.

    Resultado de la investigación: Article

    Neurogenesis
    Hippocampus
    Glycogen Synthase Kinase 3
    Catenins
    Neurons
    11 Citas (Scopus)

    CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells

    Flores-Santibáñez, F., Fernández, D., Meza, D., Tejón, G., Vargas, L., Varela-Nallar, L., Arredondo, S., Guixé, V., Rosemblatt, M., Bono, M. R. & Sauma, D., 1 dic 2015, En : Immunology. 146, 4, p. 582-594 13 p.

    Resultado de la investigación: Article

    Adenosine
    Stem Cells
    T-Lymphocytes
    Transforming Growth Factors
    Immunosuppressive Agents
    22 Citas (Scopus)

    Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

    Cisternas, P., Salazar, P., Serrano, F. G., Montecinos-Oliva, C., Arredondo, S. B., Varela-Nallar, L., Barja, S., Vio, C. P., Gomez-Pinilla, F. & Inestrosa, N. C., 1 nov 2015, En : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 11, p. 2379-2390 12 p.

    Resultado de la investigación: Article

    Neuronal Plasticity
    Fructose
    Metabolic Brain Diseases
    Hippocampus
    Learning
    4 Citas (Scopus)

    The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons

    Alfaro, I. E., Varela-Nallar, L., Varas-Godoy, M. & Inestrosa, N. C., 1 jul 2015, En : Molecular and Cellular Neuroscience. 67, p. 22-30 9 p.

    Resultado de la investigación: Article

    Receptor Tyrosine Kinase-like Orphan Receptors
    Dendritic Spines
    Receptor Protein-Tyrosine Kinases
    Morphogenesis
    Neurons
    55 Citas (Scopus)

    Wnt signalling in neuronal differentiation and development

    Inestrosa, N. C. & Varela-Nallar, L., 2015, En : Cell and Tissue Research. 359, 1, p. 215-223 9 p.

    Resultado de la investigación: Article

    Dendritic Spines
    Neurogenesis
    Dendrites
    Synaptic Transmission
    Axons
    2014
    34 Citas (Scopus)

    Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo

    Varela-Nallar, L., Rojas-Abalos, M., Abbott, A. C., Moya, E. A., Iturriaga, R. & Inestrosa, N. C., 10 feb 2014, En : Frontiers in Cellular Neuroscience. 8, FEB, 17.

    Resultado de la investigación: Article

    Catenins
    Wnt Signaling Pathway
    Neurogenesis
    Transgenic Mice
    Hippocampus
    25 Citas (Scopus)

    PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors

    Bustos, F. J., Varela-Nallar, L., Campos, M., Henriquez, B., Phillips, M., Opazo, C., Aguayo, L. G., Montecino, M., Constantine-Paton, M., Inestrosa, N. C. & Van Zundert, B., 4 abr 2014, En : PLoS ONE. 9, 4, e94037.

    Resultado de la investigación: Article

    Neurons
    Neuronal Plasticity
    Cluster Analysis
    neurons
    scaffolding proteins
    117 Citas (Scopus)

    Wnt signaling in the nervous system and in Alzheimer's disease

    Inestrosa, N. C. & Varela-Nallar, L., feb 2014, En : Journal of Molecular Cell Biology. 6, 1, p. 64-74 11 p.

    Resultado de la investigación: Review article

    Nervous System
    Alzheimer Disease
    Biological Phenomena
    Wnt Signaling Pathway
    Neuronal Plasticity
    2013
    16 Citas (Scopus)

    Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons.

    Slater, P. G., Ramirez, V. T., Gonzalez-Billault, C., Varela-Nallar, L. & Inestrosa, N. C., 1 ene 2013, En : PLoS ONE. 8, 10

    Resultado de la investigación: Article

    Frizzled Receptors
    Morphogenesis
    Neurons
    morphogenesis
    neurons
    24 Citas (Scopus)

    Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 Mice

    Abbott, A. C., Calderon Toledo, C., Aranguiz, F. C., Inestrosa, N. C. & Varela-Nallar, L., 2013, En : Journal of Alzheimer's Disease. 34, 4, p. 873-885 13 p.

    Resultado de la investigación: Article

    Neurogenesis
    Alzheimer Disease
    Cell Proliferation
    hyperforin
    Neurons
    76 Citas (Scopus)

    Wnt signaling in the regulation of adult hippocampal neurogenesis

    Varela-Nallar, L. & Inestrosa, N. C., 7 jun 2013, En : Frontiers in Cellular Neuroscience. JUNE

    Resultado de la investigación: Article

    Neurogenesis
    Catenins
    Wnt Signaling Pathway
    Lateral Ventricles
    Parahippocampal Gyrus
    2012
    13 Citas (Scopus)

    Frizzled receptors in neurons: From growth cones to the synapse

    Varela-Nallar, L., Ramirez, V. T., Gonzalez-Billault, C. & Inestrosa, N. C., jul 2012, En : Cytoskeleton. 69, 7, p. 528-534 7 p.

    Resultado de la investigación: Article

    Frizzled Receptors
    Growth Cones
    Wnt Signaling Pathway
    Synapses
    Wnt Receptors
    41 Citas (Scopus)

    SIRT1 Regulates Dendritic Development in Hippocampal Neurons

    Codocedo, J. F., Allard, C., Godoy, J. A., Varela-Nallar, L. & Inestrosa, N. C., 4 oct 2012, En : PLoS ONE. 7, 10, e47073.

    Resultado de la investigación: Article

    Neurons
    neurons
    Neuronal Plasticity
    resveratrol
    histone deacetylase
    21 Citas (Scopus)

    Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity

    Varela-Nallar, L., Parodi, J., Farías, G. G. & Inestrosa, N. C., abr 2012, En : Neurodegenerative Diseases. 10, 1-4, p. 23-26 4 p.

    Resultado de la investigación: Article

    Cluster Analysis
    Neurons
    Synapses
    Hippocampus
    Dendritic Spines
    2011
    45 Citas (Scopus)

    Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: A possible effect on APP processing

    Inestrosa, N. C., Tapia-Rojas, C., Griffith, T. N., Carvajal, F. J., Benito, M. J., Rivera-Dictter, A., Alvarez, A. R., Serrano, F. G., Hancke, J. L., Burgos, P. V., Parodi, J. & Varela-Nallar, L., 12 jul 2011, En : Translational Psychiatry. 1, e20.

    Resultado de la investigación: Article

    Alzheimer Disease
    Phosphorylation
    Aptitude
    hyperforin
    Neuronal Plasticity
    3 Citas (Scopus)

    The cellular prion protein prevents copper-induced inhibition of P2X 4 receptors

    Lorca, R. A., Varela-Nallar, L., Inestrosa, N. C. & Huidobro-Toro, J. P., 2011, En : International Journal of Alzheimer's Disease. 706576.

    Resultado de la investigación: Article

    Copper
    Adenosine Triphosphate
    Oocytes
    Protein C
    Synaptic Transmission
    2010
    38 Citas (Scopus)

    Adult hippocampal neurogenesis in aging and Alzheimer's disease

    Varela-Nallar, L., Aranguiz, F. C., Abbott, A. C., Slater, P. G. & Inestrosa, N. C., dic 2010, En : Birth Defects Research Part C - Embryo Today: Reviews. 90, 4, p. 284-296 13 p.

    Resultado de la investigación: Review article

    Neurogenesis
    Alzheimer Disease
    Lateral Ventricles
    Animal Disease Models
    Parahippocampal Gyrus
    57 Citas (Scopus)

    Neurobiological effects of hyperforin and its potential in Alzheimer's disease therapy

    Griffith, T. N., Varela-Nallar, L., Dinamarca, M. C. & Inestrosa, N. C., feb 2010, En : Current Medicinal Chemistry. 17, 5, p. 391-406 16 p.

    Resultado de la investigación: Review article

    Alzheimer Disease
    Hypericum
    Aptitude
    Chemical activation
    Phloroglucinol
    10 Citas (Scopus)

    Oxidative damage in lymphocytes of copper smelter workers correlated to higher levels of excreted arsenic

    Rios, M., Escobar, J., Varela-Nallar, L., Coddou, C., Nelson, P., Maisey, K., Valdés, D., Aspee, A., Espinosa, V., Rozas, C., Montoya, M., Mandiola, C., Rodríguez, F. E., Acua-Castillo, C., Escobar, A., Fernández, R., Diaz, H., Sandoval, M. & Imarai, M., 1 dic 2010, En : Mediators of Inflammation. 2010, 403830.

    Resultado de la investigación: Article

    Arsenic
    Copper
    Lymphocytes
    Vitamin E
    Population
    32 Citas (Scopus)

    Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation

    Perez de Arce, K., Varela-Nallar, L., Farias, O., Cifuentes, A., Bull, P., Couch, B. A., Koleske, A. J., Inestrosa, N. C. & Alvarez, A. R., 10 mar 2010, En : Journal of Neuroscience. 30, 10, p. 3728-3738 11 p.

    Resultado de la investigación: Article

    Cluster Analysis
    Tyrosine
    Phosphorylation
    Synapses
    Neurons
    123 Citas (Scopus)

    Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

    Varela-Nallar, L., Alfaro, I. E., Serrano, F. G., Parodi, J. & Inestrosa, N. C., 7 dic 2010, En : Proceedings of the National Academy of Sciences of the United States of America. 107, 49, p. 21164-21169 6 p.

    Resultado de la investigación: Article

    Synapses
    Excitatory Postsynaptic Potentials
    Spine
    Central Nervous System
    Neuronal Plasticity
    22 Citas (Scopus)

    Wnt signaling modulates pre- and postsynaptic maturation: Therapeutic considerations

    Farías, G. G., Godoy, J. A., Cerpa, W., Varela-Nallar, L. & Inestrosa, N. C., ene 2010, En : Developmental Dynamics. 239, 1, p. 94-101 8 p.

    Resultado de la investigación: Review article

    Wnt Signaling Pathway
    Nervous System
    Ligands
    Neurites
    Neurodegenerative Diseases
    2009
    52 Citas (Scopus)

    Calcium/calmodulin-dependent protein kinase type IV Is a target gene of the Wnt/β-catenin signaling pathway

    Arrázola, M. S., Varela-Nallar, L., Colombres, M., Toledo, E. M., Cruzat, F., Pavez, L., Assar, R., Aravena, A., González, M., Montecino, M., Maass, A., Martínez, S. & Inestrosa, N. C., dic 2009, En : Journal of Cellular Physiology. 221, 3, p. 658-667 10 p.

    Resultado de la investigación: Article

    Calcium-Calmodulin-Dependent Protein Kinase Type 4
    Catenins
    Wnt Signaling Pathway
    Genes
    Neurons

    Role of Alzheimer's β-Amyloid on Wnt signaling

    Inestrosa, N. C., Grabowski, C., Arrázola, M., Varela-Nallar, L. & Toledo, E. M., 2009, Protein Misfolding Disorders. Bentham Science Publishers Ltd., p. 103-113 11 p.

    Resultado de la investigación: Chapter

    Catenins
    Amyloid
    Frizzled Receptors
    Glycogen Synthase Kinase 3
    Dendritic Spines
    72 Citas (Scopus)

    Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function

    Varela-Nallar, L., Grabowski, C. P., Alfaro, I. E., Alvarez, A. R. & Inestrosa, N. C., 2009, En : Neural Development. 4, 1, 41.

    Resultado de la investigación: Article

    Wnt Receptors
    Wnt Signaling Pathway
    Synapses
    Cysteine
    Cluster Analysis
    42 Citas (Scopus)

    The role of WNT signaling in neuroprotection

    Cerpa, W., Toledo, E. M., Varela-Nallar, L. & Inestrosa, N. C., dic 2009, En : Drug News and Perspectives. 22, 10, p. 579-591 13 p.

    Resultado de la investigación: Review article

    Wnt Signaling Pathway
    Catenins
    Alzheimer Disease
    Neuronal Plasticity
    Long-Term Potentiation
    2008
    60 Citas (Scopus)

    Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers

    Chacón, M. A., Varela-Nallar, L. & Inestrosa, N. C., oct 2008, En : Journal of Cellular Physiology. 217, 1, p. 215-227 13 p.

    Resultado de la investigación: Article

    Catenins
    Wnt Signaling Pathway
    Neuroprotective Agents
    Oligomers
    Toxicity
    2007
    48 Citas (Scopus)

    Synaptotoxicity in Alzheimer's disease: The Wnt signaling pathway as a molecular target

    Inestrosa, N. C., Varela-Nallar, L., Grabowski, C. P. & Colombres, M., 2007, En : IUBMB Life. 59, 4-5, p. 316-321 6 p.

    Resultado de la investigación: Article

    Wnt Signaling Pathway
    Alzheimer Disease
    Glycogen Synthase Kinase 3
    Oligomers
    Brain
    2006
    51 Citas (Scopus)

    Induction of cellular prion protein gene expression by copper in neurons

    Varela-Nallar, L., Toledo, E. M., Larrondo, L. F., Cabral, A. L. B., Martins, V. R. & Inestrosa, N. C., 1 ene 2006, En : American Journal of Physiology - Cell Physiology. 290, 1

    Resultado de la investigación: Article

    Copper
    Gene Expression
    Neurons
    Zinc
    Clone Cells
    17 Citas (Scopus)

    Role of copper in prion diseases: Deleterious or beneficial?

    Varela-Nallar, L., González, A. & Inestrosa, N. C., jul 2006, En : Current Pharmaceutical Design. 12, 20, p. 2587-2595 9 p.

    Resultado de la investigación: Review article

    Prion Diseases
    Copper
    Prions
    Endocytosis
    Neurodegenerative Diseases
    17 Citas (Scopus)

    The functional links between prion protein and copper

    Varela-Nallar, L., Toledo, E. M., Chacón, M. A. & Inestrosa, N. C., 1 ene 2006, En : Biological Research. 39, 1, p. 39-44 6 p.

    Resultado de la investigación: Article

    prions
    Copper
    copper
    PrPC Proteins
    terminal repeat sequences
    2005
    24 Citas (Scopus)

    Copper brain homeostasis: Role of amyloid precursor protein and prion protein

    Inestrosa, N. C., Cerpa, W. & Varela-Nallar, L., sep 2005, En : IUBMB Life. 57, 9, p. 645-650 6 p.

    Resultado de la investigación: Review article

    Amyloid beta-Protein Precursor
    Copper
    Brain
    Homeostasis
    PrPC Proteins
    7 Citas (Scopus)

    Fas ligand in the uterus of the non-pregnant mouse induces apoptosis of CD4+ T cells

    Imarai, M., Varela-Nallar, L., Figueroa-Gaete, C., González, P., Valdés, D., Velásquez, L., Cárdenas, H. & Maisey, K., 1 jun 2005, En : Journal of Reproductive Immunology. 66, 1, p. 13-32 20 p.

    Resultado de la investigación: Article

    Fas Ligand Protein
    Uterus
    Apoptosis
    T-Lymphocytes
    Oviducts
    59 Citas (Scopus)

    Is there a role for copper in neurodegenerative diseases?

    Cerpa, W., Varela-Nallar, L., Reyes, A. E., Minniti, A. N. & Inestrosa, N. C., 1 ago 2005, En : Molecular Aspects of Medicine. 26, 4-5 SPEC. ISS., p. 405-420 16 p.

    Resultado de la investigación: Review article

    Neurodegenerative diseases
    Neurodegenerative Diseases
    Copper
    Metabolism
    Prion Diseases
    2002
    2 Citas (Scopus)

    IgA in the lumen of the human oviduct is not related to the menstrual cycle but increases during local inflammation

    Arraztoa, J. A., Rocha, A., Varela-Nallar, L., Velasquez, L., Toro, V., Cardenas, H. & Imarai, M., 2002, En : Fertility and Sterility. 77, 3, p. 633-634 2 p.

    Resultado de la investigación: Comment/debate

    2000
    16 Citas (Scopus)

    Expression of intercellular adhesion molecule 1 (ICAM-1) on the human oviductal epithelium and mediation of lymphoid cell adherence

    Utreras, E., Ossandon, P., Acuna-Castillo, C., Varela-Nallar, L., Muller, C., Arraztoa, J. A., Cardenas, H. & Imarai, M., 2000, En : Journal of Reproduction and Fertility. 120, 1, p. 115-123 9 p.

    Resultado de la investigación: Article

    Intercellular Adhesion Molecule-1
    Epithelium
    Lymphocytes
    Oviducts
    Major Histocompatibility Complex