Resultado de la investigación 2003 2018

Filtro
Article
2018

Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation

Cabrera, D., Cabello-Verrugio, C., Solís, N., Martín, D. S., Cofré, C., Pizarro, M., Arab, J. P., Abrigo, J., Campos, F., Irigoyen, B., Carrasco-Avino, G., Bezares, K., Riquelme, V., Riquelme, A., Arrese, M. & Barrera, F. 2 may 2018 En : International Journal of Molecular Sciences. 19, 5, 1339

Resultado de la investigación: Contribución a la publicaciónArticle

diets
hormones
Hormones
High Fat Diet
Nutrition

TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy

Ábrigo, J., Campos, F., Simon, F., Riedel, C., Cabrera, D., Vilos, C. & Cabello-Verrugio, C. 23 feb 2018 En : Biological Chemistry. 399, 3, p. 253-264 12 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Muscular Atrophy
Transforming Growth Factor beta
Muscle
Skeletal Muscle
Chemical activation
2017
3 Citas

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Cabrera, D., Wree, A., Povero, D., Solís, N., Hernandez, A., Pizarro, M., Moshage, H., Torres, J., Feldstein, A. E., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. P. & Arrese, M. 1 dic 2017 En : Scientific Reports. 7, 1, 3491

Resultado de la investigación: Contribución a la publicaciónArticle

Inflammasomes
Fatty Liver
Inflammation
Liver
Hep G2 Cells
1 Citas

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway

Becerra, A., Rojas, M., Vallejos, A., Villegas, V., Pérez, L., Cabello-Verrugio, C. & Simon, F. 1 sep 2017 En : Laboratory Investigation. 97, 9, p. 1033-1046 14 p.

Resultado de la investigación: Contribución a la publicaciónArticle

STAT3 Transcription Factor
Transforming Growth Factors
Fibrosis
Endothelial Cells
Extracellular Matrix Proteins
2 Citas

The complex of PAMAM-OH dendrimer with angiotensin (1–7) prevented the disuse-induced skeletal muscle atrophy in mice

Márquez-Miranda, V., Abrigo, J., Rivera, J. C., Araya-Durán, I., Aravena, J., Simon, F., Pacheco, N., González-Nilo, F. D. & Cabello-Verrugio, C. 13 mar 2017 En : International Journal of Nanomedicine. 12, p. 1985-1999 15 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Dendrimers
Muscular Atrophy
Muscle
Skeletal Muscle
Peptides
2016
9 Citas

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Morales, M. G., Abrigo, J., Acuna, M. J., Santos, R. A., Bader, M., Brandan, E., Simon, F., Olguin, H., Cabrera, D. & Cabello-Verrugio, C. 1 abr 2016 En : DMM Disease Models and Mechanisms. 9, 4, p. 441-449 9 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Muscular Atrophy
Muscle
Skeletal Muscle
Immobilization
Renin-Angiotensin System
1 Citas

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

Ábrigo, J., Simon, F., Cabrera, D. & Cabello-Verrugio, C. 1 nov 2016 En : Cellular Physiology and Biochemistry. 40, 1-2, p. 27-38 12 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Muscular Atrophy
Transforming Growth Factor beta
Skeletal Muscle
Myosin Heavy Chains
7-Ala-angiotensin (1-7)
8 Citas

Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1

Cabrera, D., Ruiz, A., Cabello-Verrugio, C., Brandan, E., Estrada, L., Pizarro, M., Solis, N., Torres, J., Barrera, F. & Arrese, M. 1 nov 2016 En : Digestive Diseases and Sciences. 61, 11, p. 3190-3198 9 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Sarcopenia
Somatomedins
Diet
Muscles
Liver
3 Citas

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis

Abrigo, J., Rivera, J. C., Aravena, J., Cabrera, D., Simon, F., Ezquer, F., Ezquer, M. & Cabello-Verrugio, C. 1 ene 2016 En : Oxidative Medicine and Cellular Longevity. 2016, 9047821

Resultado de la investigación: Contribución a la publicaciónArticle

Oxidative stress
High Fat Diet
Proteasome Endopeptidase Complex
Nutrition
Ubiquitin
14 Citas

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

Abrigo, J., Rivera, J. C., Simon, F., Cabrera, D. & Cabello-Verrugio, C. 1 may 2016 En : Cellular Signalling. 28, 5, p. 366-376 11 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Muscular Atrophy
Transforming Growth Factor beta
Reactive Oxygen Species
Skeletal Muscle
Skeletal Muscle Fibers
2015
21 Citas

Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism

Cisternas, F., Morales, M. G., Meneses, C., Simon, F., Brandan, E., Abrigo, J., Vazquez, Y. & Cabello-Verrugio, C. 2015 En : Clinical Science. 128, 5, p. 307-319 13 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Muscular Atrophy
Angiotensin II
Skeletal Muscle
Myosin Heavy Chains
Skeletal Muscle Fibers
9 Citas

Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells

Abrigo, J., Morales, M. G., Simon, F., Cabrera, D., Capua, G. D. & Cabello-Verrugio, C. 27 jul 2015 En : Phytomedicine. 22, 10, p. 885-893 9 p., 51860

Resultado de la investigación: Contribución a la publicaciónArticle

Transforming Growth Factor beta
Muscle Cells
Reactive Oxygen Species
Skeletal Muscle
Up-Regulation
17 Citas

Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism

Morales, M. G., Olguín, H., Capua, G. D., Brandan, E., Simon, F. & Cabello-Verrugio, C. 1 ene 2015 En : Clinical Science. 129, 6, p. 461-476 16 p.

Resultado de la investigación: Contribución a la publicaciónArticle

p38 Mitogen-Activated Protein Kinases
Endotoxins
Skeletal Muscle
Lipopolysaccharides
Muscular Atrophy
10 Citas

Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel

Sarmiento, D., Montorfano, I., Cerda, O., Cáceres, M., Becerra, A., Cabello-Verrugio, C., Elorza, A. A., Riedel, C., Tapia, P., Velásquez, L. A., Varela, D. & Simon, F. 1 mar 2015 En : Microvascular Research. 98, p. 187-196 10 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Endothelial cells
Oxidative stress
Ion Channels
Cell Movement
Reactive Oxygen Species
17 Citas

Renin-angiotensin system: An old player with novel functions in skeletal muscle

Cabello-Verrugio, C., Morales, M. G., Rivera, J. C., Cabrera, D. & Simon, F. 1 may 2015 En : Medicinal Research Reviews. 35, 3, p. 437-463 27 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Renin-Angiotensin System
Skeletal Muscle
Insulin Resistance
Fibrosis
Atrophy
8 Citas

Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway

Echeverría, C., Montorfano, I., Cabello-Verrugio, C., Armisén, R., Varela, D. & Simon, F. 1 ene 2015 En : Journal of Hypertension. 33, 5, p. 981-992 12 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Growth Factor Receptors
Transforming Growth Factors
Fibrosis
Endothelial Cells
Fibroblasts
15 Citas

The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice

Meneses, C., Morales, M. G., Abrigo, J., Simon, F., Brandan, E. & Cabello-Verrugio, C. 1 sep 2015 En : Pflugers Archiv European Journal of Physiology. 467, 9, p. 1975-1984 10 p., A001

Resultado de la investigación: Contribución a la publicaciónArticle

Muscular Atrophy
Angiotensin II
Muscle
Skeletal Muscle
Apoptosis
4 Citas

Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies

Cofre, C., Acuña, M. J., Contreras, O., Morales, M. G., Riquelme, C., Cabello-Verrugio, C. & Brandan, E. 1 mar 2015 En : BioFactors. 41, 2, p. 111-120 10 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Muscular Dystrophies
Myoblasts
Skeletal Muscle Fibers
Fibroblasts
Transforming Growth Factor beta
2014
14 Citas

Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

Cabrera, D., Gutiérrez, J., Cabello-Verrugio, C., Morales, M. G., Mezzano, S., Fadic, R., Casar, J. C., Hancke, J. L. & Brandan, E. 21 mar 2014 En : Skeletal Muscle. 4, 1, 6

Resultado de la investigación: Contribución a la publicaciónArticle

Inbred mdx Mouse
Cell- and Tissue-Based Therapy
Skeletal Muscle
Fibrosis
Duchenne Muscular Dystrophy
10 Citas

Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2

Echeverría, C., Montorfano, I., Tapia, P., Riedel, C., Cabello-Verrugio, C. & Simon, F. 2014 En : Infection and Immunity. 82, 9, p. 3678-3686 9 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Transforming Growth Factors
Endotoxins
Fibrosis
Endothelial Cells
Transforming Growth Factor beta
13 Citas

Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity

Sarmiento, D., Montorfano, I., Cáceres, M., Echeverría, C., Fernández, R., Cabello-Verrugio, C., Cerda, O., Tapia, P. & Simon, F. 1 ene 2014 En : International Journal of Biochemistry and Cell Biology. 55, p. 11-23 13 p.

Resultado de la investigación: Contribución a la publicaciónArticle

NADPH Oxidase
Endothelial cells
Calcium Channels
Endotoxins
Cell Movement
18 Citas

Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity

Echeverría, C., Montorfano, I., Hermosilla, T., Armisén, R., Velásquez, L. A., Cabello-Verrugio, C., Varela, D. & Simon, F. 7 abr 2014 En : PLoS ONE. 9, 4, e94146

Resultado de la investigación: Contribución a la publicaciónArticle

Endothelial cells
endotoxins
fibrosis
blood vessels
Endotoxins
13 Citas

Expression of the Mas receptor is upregulated in skeletal muscle wasting

Morales, M. G., Abrigo, J., Meneses, C., Cisternas, F., Simon, F. & Cabello-Verrugio, C. 1 ene 2014 En : Histochemistry and Cell Biology. 143, 2, p. 131-141 11 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Angiotensin II
Skeletal Muscle
Lipopolysaccharides
Renin-Angiotensin System
Immobilization
34 Citas

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-b1 and TGF-b2-dependent pathway

Montorfano, I., Becerra, A., Cerro, R., Echeverría, C., Sáez, E., Morales, M. G., Fernández, R., Cabello-Verrugio, C. & Simon, F. 1 ene 2014 En : Laboratory Investigation. 94, 10, p. 1068-1082 15 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Myofibroblasts
Oxidative Stress
Endothelial Cells
Inflammation
p38 Mitogen-Activated Protein Kinases
61 Citas

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

Acuña, M. J., Pessina, P., Olguin, H., Cabrera, D., Vio, C. P., Bader, M., Muñoz-canoves, P., Santos, R. A., Cabello-verrugio, C. & Brandan, E. 1 mar 2014 En : Human Molecular Genetics. 23, 5, p. 1237-1249 13 p., ddt514

Resultado de la investigación: Contribución a la publicaciónArticle

Muscle Strength
Inbred mdx Mouse
Transforming Growth Factor beta
Duchenne Muscular Dystrophy
Muscles
22 Citas

The ang-(1-7)/mas-1 axis attenuates the expression and signalling of TGF-β1 induced by angii in mouse skeletal muscle

Morales, M. G., Ábrigo, J., Meneses, C., Simon, F., Cisternas, F., Rivera, J. C., Vazquez, Y. & Cabello-Verrugio, C. 2014 En : Clinical Science. 127, 4, p. 251-264 14 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Transforming Growth Factors
Skeletal Muscle
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Reactive Oxygen Species
2013
33 Citas

Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)

Morales, M. G., Cabrera, D., Céspedes, C., Vio, C. P., Vazquez, Y., Brandan, E. & Cabello-Verrugio, C. 1 jul 2013 En : Cell and Tissue Research. 353, 1, p. 173-187 15 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Connective Tissue Growth Factor
Inbred mdx Mouse
Peptidyl-Dipeptidase A
Skeletal Muscle
Fibrosis
21 Citas

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells

Echeverría, C., Montorfano, I., Sarmiento, D., Becerra, A., Nuñez-Villena, F., Figueroa, X. F., Cabello-Verrugio, C., Elorza, A. A., Riedel, C. & Simon, F. jun 2013 En : Journal of Cellular and Molecular Medicine. 17, 6, p. 800-814 15 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Lipopolysaccharides
Endothelial Cells
Phenotype
Fibrosis
Systemic Inflammatory Response Syndrome
42 Citas

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

Morales, M. G., Gutierrez, J., Cabello-Verrugio, C., Cabrera, D., Lipson, K. E., Goldschmeding, R. & Brandan, E. 1 dic 2013 En : Human Molecular Genetics. 22, 24, p. 4938-4951 14 p., ddt352

Resultado de la investigación: Contribución a la publicaciónArticle

Inbred mdx Mouse
Cell- and Tissue-Based Therapy
Duchenne Muscular Dystrophy
Muscles
Dystrophin
18 Citas

Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle

Painemal, P., Acuña, M. J., Riquelme, C., Brandan, E. & Cabello-Verrugio, C. jul 2013 En : BioFactors. 39, 4, p. 467-475 9 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Angiotensin Type 2 Receptor
p38 Mitogen-Activated Protein Kinases
Transforming Growth Factor beta
Muscle
Skeletal Muscle
2012
41 Citas

Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells

Morales, M. G., Vazquez, Y., Acuña, M. J., Rivera, J. C., Simon, F., Salas, J. D., Álvarez Ruf, J., Brandan, E. & Cabello-Verrugio, C. 1 nov 2012 En : International Journal of Biochemistry and Cell Biology. 44, 11, p. 1993-2002 10 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Angiotensin II
Transforming Growth Factor beta
Muscle Cells
Muscle
Skeletal Muscle
38 Citas

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

Cabello-Verrugio, C., Morales, M. G., Cabrera, D., Vio, C. P. & Brandan, E. 2012 En : Journal of Cellular and Molecular Medicine. 16, 4, p. 752-764 13 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Angiotensin Type 1 Receptor
Skeletal Muscle
Fibrosis
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
31 Citas
Low Density Lipoprotein Receptor-Related Protein-1
Decorin
Leucine
Transforming Growth Factor beta
Muscle
2011
33 Citas

Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type β receptors and the JNK pathway

Cabello-Verrugio, C., Córdova, G., Vial, C., Zúñiga, L. M. & Brandan, E. 1 feb 2011 En : Cellular Signalling. 23, 2, p. 449-457 9 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Connective Tissue Growth Factor
Transforming Growth Factor beta Receptors
MAP Kinase Signaling System
Transcriptional Activation
Transforming Growth Factor beta
51 Citas

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

Morales, M. G., Cabello-Verrugio, C., Santander, C., Cabrera, D., Goldschmeding, R. & Brandan, E. dic 2011 En : Journal of Pathology. 225, 4, p. 490-501 12 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Skeletal Muscle
Muscles
Muscular Dystrophies
Phenotype
Cicatrix
40 Citas

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

Cabello-Verrugio, C., Acuña, M. J., Morales, M. G., Becerra, A., Simon, F. & Brandan, E. 8 jul 2011 En : Biochemical and Biophysical Research Communications. 410, 3, p. 665-670 6 p.

Resultado de la investigación: Contribución a la publicaciónArticle

NADPH Oxidase
Angiotensin II
Muscle Cells
Muscle
Reactive Oxygen Species
2010
22 Citas

TGF-β receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation

Droguett, R., Cabello-Verrugio, C., Santander, C. & Brandan, E. 1 ene 2010 En : Experimental Cell Research. 316, 15, p. 2487-2503 17 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Transforming Growth Factor beta Receptors
Transforming Growth Factor beta
Skeletal Muscle
Smad Proteins
Myosins
2008
61 Citas

Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

Vial, C., Zúñiga, L. M., Cabello-Verrugio, C., Cañón, P., Fadic, R. & Brandan, E. may 2008 En : Journal of Cellular Physiology. 215, 2, p. 410-421 12 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Connective Tissue Growth Factor
Muscle Cells
Muscle
Myoblasts
Skeletal Muscle
2007
86 Citas

A novel modulatory mechanism of transforming growth factor-β signaling through decorin and LRP-1

Cabello-Verrugio, C. & Brandan, E. 29 jun 2007 En : Journal of Biological Chemistry. 282, 26, p. 18842-18850 9 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Decorin
Transforming Growth Factor beta
Myoblasts
Smad Proteins
Phosphatidylinositol 3-Kinase
2006
87 Citas

Extracellular proteoglycans modify TGF-β bio-availability attenuating its signaling during skeletal muscle differentiation

Droguett, R., Cabello-Verrugio, C., Riquelme, C. & Brandan, E. 1 ago 2006 En : Matrix Biology. 25, 6, p. 332-341 10 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Decorin
Proteoglycans
Transforming Growth Factor beta
Myoblasts
Skeletal Muscle
39 Citas

The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin

Brandan, E., Retamal, C., Cabello-Verrugio, C. & Marzolo, M. P. 20 oct 2006 En : Journal of Biological Chemistry. 281, 42, p. 31562-31571 10 p.

Resultado de la investigación: Contribución a la publicaciónArticle

LDL-Receptor Related Proteins
Lipoprotein Receptors
Decorin
LDL Receptors
CHO Cells
2004
83 Citas

Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: Requirement of syndecan-3 for successful fiber formation

Casar, J. C., Cabello-Verrugio, C., Olguin, H., Aldunate, R., Inestrosa, N. C. & Brandan, E. 1 ene 2004 En : Journal of Cell Science. 117, 1, p. 73-84 12 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Syndecan-3
Heparan Sulfate Proteoglycans
Regeneration
Skeletal Muscle
Muscles
2003
35 Citas

Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation: Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-β

López-Casillas, F., Riquelme, C., Pérez-Kato, Y., Veronica Ponce-Castaneda, M., Osses, N., Esparza-Lopez, J., Gonzalez-Nunez, G., Cabello-Verrugio, C., Mendoza, V., Troncoso, V. & Brandan, E. 3 ene 2003 En : Journal of Biological Chemistry. 278, 1, p. 382-390 9 p.

Resultado de la investigación: Contribución a la publicaciónArticle

Cloning
Tretinoin
Transforming Growth Factor beta
Muscle
Organism Cloning