CLAUDIO ALEJANDRO CABELLO VERRUGIO – Resultado de la investigación

2018

Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation

Cabrera, D., Cabello-Verrugio, C., Solís, N., Martín, D. S., Cofré, C., Pizarro, M., Arab, J. P., Abrigo, J., Campos, F., Irigoyen, B., Carrasco-Avino, G., Bezares, K., Riquelme, V., Riquelme, A., Arrese, M. & Barrera, F. 2 may 2018 En : International Journal of Molecular Sciences. 19, 5, 1339

Resultado de la investigación: Contribución a la publicación › Article

diets

hormones

Hormones

High Fat Diet

Nutrition

TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy

Ábrigo, J., Campos, F., Simon, F., Riedel, C., Cabrera, D., Vilos, C. & Cabello-Verrugio, C. 23 feb 2018 En : Biological Chemistry. 399, 3, p. 253-264 12 p.

Resultado de la investigación: Contribución a la publicación › Article

Muscular Atrophy

Transforming Growth Factor beta

Muscle

Skeletal Muscle

Chemical activation

2017

3 Citas

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Cabrera, D., Wree, A., Povero, D., Solís, N., Hernandez, A., Pizarro, M., Moshage, H., Torres, J., Feldstein, A. E., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. P. & Arrese, M. 1 dic 2017 En : Scientific Reports. 7, 1, 3491

Resultado de la investigación: Contribución a la publicación › Article

Inflammasomes

Fatty Liver

Inflammation

Liver

Hep G2 Cells

1 Citas

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway

Becerra, A., Rojas, M., Vallejos, A., Villegas, V., Pérez, L., Cabello-Verrugio, C. & Simon, F. 1 sep 2017 En : Laboratory Investigation. 97, 9, p. 1033-1046 14 p.

Resultado de la investigación: Contribución a la publicación › Article

STAT3 Transcription Factor

Transforming Growth Factors

Fibrosis

Endothelial Cells

Extracellular Matrix Proteins

2 Citas

The complex of PAMAM-OH dendrimer with angiotensin (1–7) prevented the disuse-induced skeletal muscle atrophy in mice

Márquez-Miranda, V., Abrigo, J., Rivera, J. C., Araya-Durán, I., Aravena, J., Simon, F., Pacheco, N., González-Nilo, F. D. & Cabello-Verrugio, C. 13 mar 2017 En : International Journal of Nanomedicine. 12, p. 1985-1999 15 p.

Resultado de la investigación: Contribución a la publicación › Article

Dendrimers

Muscular Atrophy

Muscle

Skeletal Muscle

Peptides

2016

9 Citas

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Morales, M. G., Abrigo, J., Acuna, M. J., Santos, R. A., Bader, M., Brandan, E., Simon, F., Olguin, H., Cabrera, D. & Cabello-Verrugio, C. 1 abr 2016 En : DMM Disease Models and Mechanisms. 9, 4, p. 441-449 9 p.

Resultado de la investigación: Contribución a la publicación › Article

Muscular Atrophy

Muscle

Skeletal Muscle

Immobilization

Renin-Angiotensin System

1 Citas

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

Ábrigo, J., Simon, F., Cabrera, D. & Cabello-Verrugio, C. 1 nov 2016 En : Cellular Physiology and Biochemistry. 40, 1-2, p. 27-38 12 p.

Resultado de la investigación: Contribución a la publicación › Article

Muscular Atrophy

Transforming Growth Factor beta

Skeletal Muscle

Myosin Heavy Chains

7-Ala-angiotensin (1-7)

8 Citas

Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1

Cabrera, D., Ruiz, A., Cabello-Verrugio, C., Brandan, E., Estrada, L., Pizarro, M., Solis, N., Torres, J., Barrera, F. & Arrese, M. 1 nov 2016 En : Digestive Diseases and Sciences. 61, 11, p. 3190-3198 9 p.

Resultado de la investigación: Contribución a la publicación › Article

Sarcopenia

Somatomedins

Diet

Muscles

Liver

3 Citas

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis

Abrigo, J., Rivera, J. C., Aravena, J., Cabrera, D., Simon, F., Ezquer, F., Ezquer, M. & Cabello-Verrugio, C. 1 ene 2016 En : Oxidative Medicine and Cellular Longevity. 2016, 9047821

Resultado de la investigación: Contribución a la publicación › Article

Oxidative stress

High Fat Diet

Proteasome Endopeptidase Complex

Nutrition

Ubiquitin

14 Citas

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

Abrigo, J., Rivera, J. C., Simon, F., Cabrera, D. & Cabello-Verrugio, C. 1 may 2016 En : Cellular Signalling. 28, 5, p. 366-376 11 p.

Resultado de la investigación: Contribución a la publicación › Article

Muscular Atrophy

Transforming Growth Factor beta

Reactive Oxygen Species

Skeletal Muscle

Skeletal Muscle Fibers

2015

21 Citas

Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism

Cisternas, F., Morales, M. G., Meneses, C., Simon, F., Brandan, E., Abrigo, J., Vazquez, Y. & Cabello-Verrugio, C. 2015 En : Clinical Science. 128, 5, p. 307-319 13 p.

Resultado de la investigación: Contribución a la publicación › Article

Muscular Atrophy

Angiotensin II

Skeletal Muscle

Myosin Heavy Chains

Skeletal Muscle Fibers

9 Citas

Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells

Abrigo, J., Morales, M. G., Simon, F., Cabrera, D., Capua, G. D. & Cabello-Verrugio, C. 27 jul 2015 En : Phytomedicine. 22, 10, p. 885-893 9 p., 51860

Resultado de la investigación: Contribución a la publicación › Article

Transforming Growth Factor beta

Muscle Cells

Reactive Oxygen Species

Skeletal Muscle

Up-Regulation

17 Citas

Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism

Morales, M. G., Olguín, H., Capua, G. D., Brandan, E., Simon, F. & Cabello-Verrugio, C. 1 ene 2015 En : Clinical Science. 129, 6, p. 461-476 16 p.

Resultado de la investigación: Contribución a la publicación › Article

p38 Mitogen-Activated Protein Kinases

Endotoxins

Skeletal Muscle

Lipopolysaccharides

Muscular Atrophy

10 Citas

Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel

Sarmiento, D., Montorfano, I., Cerda, O., Cáceres, M., Becerra, A., Cabello-Verrugio, C., Elorza, A. A., Riedel, C., Tapia, P., Velásquez, L. A., Varela, D. & Simon, F. 1 mar 2015 En : Microvascular Research. 98, p. 187-196 10 p.

Resultado de la investigación: Contribución a la publicación › Article

Endothelial cells

Oxidative stress

Ion Channels

Cell Movement

Reactive Oxygen Species

17 Citas

Renin-angiotensin system: An old player with novel functions in skeletal muscle

Cabello-Verrugio, C., Morales, M. G., Rivera, J. C., Cabrera, D. & Simon, F. 1 may 2015 En : Medicinal Research Reviews. 35, 3, p. 437-463 27 p.

Resultado de la investigación: Contribución a la publicación › Article

Renin-Angiotensin System

Skeletal Muscle

Insulin Resistance

Fibrosis

Atrophy

8 Citas

Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway

Echeverría, C., Montorfano, I., Cabello-Verrugio, C., Armisén, R., Varela, D. & Simon, F. 1 ene 2015 En : Journal of Hypertension. 33, 5, p. 981-992 12 p.

Resultado de la investigación: Contribución a la publicación › Article

Growth Factor Receptors

Transforming Growth Factors

Fibrosis

Endothelial Cells

Fibroblasts

15 Citas

The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice

Meneses, C., Morales, M. G., Abrigo, J., Simon, F., Brandan, E. & Cabello-Verrugio, C. 1 sep 2015 En : Pflugers Archiv European Journal of Physiology. 467, 9, p. 1975-1984 10 p., A001

Resultado de la investigación: Contribución a la publicación › Article

Muscular Atrophy

Angiotensin II

Muscle

Skeletal Muscle

Apoptosis

4 Citas

Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies

Cofre, C., Acuña, M. J., Contreras, O., Morales, M. G., Riquelme, C., Cabello-Verrugio, C. & Brandan, E. 1 mar 2015 En : BioFactors. 41, 2, p. 111-120 10 p.

Resultado de la investigación: Contribución a la publicación › Article

Muscular Dystrophies

Myoblasts

Skeletal Muscle Fibers

Fibroblasts

Transforming Growth Factor beta

2014

14 Citas

Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

Cabrera, D., Gutiérrez, J., Cabello-Verrugio, C., Morales, M. G., Mezzano, S., Fadic, R., Casar, J. C., Hancke, J. L. & Brandan, E. 21 mar 2014 En : Skeletal Muscle. 4, 1, 6

Resultado de la investigación: Contribución a la publicación › Article

Inbred mdx Mouse

Cell- and Tissue-Based Therapy

Skeletal Muscle

Fibrosis

Duchenne Muscular Dystrophy

10 Citas

Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2

Echeverría, C., Montorfano, I., Tapia, P., Riedel, C., Cabello-Verrugio, C. & Simon, F. 2014 En : Infection and Immunity. 82, 9, p. 3678-3686 9 p.

Resultado de la investigación: Contribución a la publicación › Article

Transforming Growth Factors

Endotoxins

Fibrosis

Endothelial Cells

Transforming Growth Factor beta

13 Citas

Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity

Sarmiento, D., Montorfano, I., Cáceres, M., Echeverría, C., Fernández, R., Cabello-Verrugio, C., Cerda, O., Tapia, P. & Simon, F. 1 ene 2014 En : International Journal of Biochemistry and Cell Biology. 55, p. 11-23 13 p.

Resultado de la investigación: Contribución a la publicación › Article

NADPH Oxidase

Endothelial cells

Calcium Channels

Endotoxins

Cell Movement

18 Citas

Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity

Echeverría, C., Montorfano, I., Hermosilla, T., Armisén, R., Velásquez, L. A., Cabello-Verrugio, C., Varela, D. & Simon, F. 7 abr 2014 En : PLoS ONE. 9, 4, e94146

Resultado de la investigación: Contribución a la publicación › Article

Endothelial cells

endotoxins

fibrosis

blood vessels

Endotoxins

13 Citas

Expression of the Mas receptor is upregulated in skeletal muscle wasting

Morales, M. G., Abrigo, J., Meneses, C., Cisternas, F., Simon, F. & Cabello-Verrugio, C. 1 ene 2014 En : Histochemistry and Cell Biology. 143, 2, p. 131-141 11 p.

Resultado de la investigación: Contribución a la publicación › Article

Angiotensin II

Skeletal Muscle

Lipopolysaccharides

Renin-Angiotensin System

Immobilization

34 Citas

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-b1 and TGF-b2-dependent pathway

Montorfano, I., Becerra, A., Cerro, R., Echeverría, C., Sáez, E., Morales, M. G., Fernández, R., Cabello-Verrugio, C. & Simon, F. 1 ene 2014 En : Laboratory Investigation. 94, 10, p. 1068-1082 15 p.

Resultado de la investigación: Contribución a la publicación › Article

Myofibroblasts

Oxidative Stress

Endothelial Cells

Inflammation

p38 Mitogen-Activated Protein Kinases

61 Citas

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

Acuña, M. J., Pessina, P., Olguin, H., Cabrera, D., Vio, C. P., Bader, M., Muñoz-canoves, P., Santos, R. A., Cabello-verrugio, C. & Brandan, E. 1 mar 2014 En : Human Molecular Genetics. 23, 5, p. 1237-1249 13 p., ddt514

Resultado de la investigación: Contribución a la publicación › Article

Muscle Strength

Inbred mdx Mouse

Transforming Growth Factor beta

Duchenne Muscular Dystrophy

Muscles

22 Citas

The ang-(1-7)/mas-1 axis attenuates the expression and signalling of TGF-β1 induced by angii in mouse skeletal muscle

Morales, M. G., Ábrigo, J., Meneses, C., Simon, F., Cisternas, F., Rivera, J. C., Vazquez, Y. & Cabello-Verrugio, C. 2014 En : Clinical Science. 127, 4, p. 251-264 14 p.

Resultado de la investigación: Contribución a la publicación › Article

Transforming Growth Factors

Skeletal Muscle

p38 Mitogen-Activated Protein Kinases

Phosphorylation

Reactive Oxygen Species

2013

33 Citas

Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)

Morales, M. G., Cabrera, D., Céspedes, C., Vio, C. P., Vazquez, Y., Brandan, E. & Cabello-Verrugio, C. 1 jul 2013 En : Cell and Tissue Research. 353, 1, p. 173-187 15 p.

Resultado de la investigación: Contribución a la publicación › Article

Connective Tissue Growth Factor

Inbred mdx Mouse

Peptidyl-Dipeptidase A

Skeletal Muscle

Fibrosis

21 Citas

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells

Echeverría, C., Montorfano, I., Sarmiento, D., Becerra, A., Nuñez-Villena, F., Figueroa, X. F., Cabello-Verrugio, C., Elorza, A. A., Riedel, C. & Simon, F. jun 2013 En : Journal of Cellular and Molecular Medicine. 17, 6, p. 800-814 15 p.

Resultado de la investigación: Contribución a la publicación › Article

Lipopolysaccharides

Endothelial Cells

Phenotype

Fibrosis

Systemic Inflammatory Response Syndrome

42 Citas

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

Morales, M. G., Gutierrez, J., Cabello-Verrugio, C., Cabrera, D., Lipson, K. E., Goldschmeding, R. & Brandan, E. 1 dic 2013 En : Human Molecular Genetics. 22, 24, p. 4938-4951 14 p., ddt352

Resultado de la investigación: Contribución a la publicación › Article

Inbred mdx Mouse

Cell- and Tissue-Based Therapy

Duchenne Muscular Dystrophy

Muscles

Dystrophin

18 Citas

Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle

Painemal, P., Acuña, M. J., Riquelme, C., Brandan, E. & Cabello-Verrugio, C. jul 2013 En : BioFactors. 39, 4, p. 467-475 9 p.

Resultado de la investigación: Contribución a la publicación › Article

Angiotensin Type 2 Receptor

p38 Mitogen-Activated Protein Kinases

Transforming Growth Factor beta

Muscle

Skeletal Muscle

2012

41 Citas

Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells

Morales, M. G., Vazquez, Y., Acuña, M. J., Rivera, J. C., Simon, F., Salas, J. D., Álvarez Ruf, J., Brandan, E. & Cabello-Verrugio, C. 1 nov 2012 En : International Journal of Biochemistry and Cell Biology. 44, 11, p. 1993-2002 10 p.

Resultado de la investigación: Contribución a la publicación › Article

Angiotensin II

Transforming Growth Factor beta

Muscle Cells

Muscle

Skeletal Muscle

38 Citas

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

Cabello-Verrugio, C., Morales, M. G., Cabrera, D., Vio, C. P. & Brandan, E. 2012 En : Journal of Cellular and Molecular Medicine. 16, 4, p. 752-764 13 p.

Resultado de la investigación: Contribución a la publicación › Article

Angiotensin Type 1 Receptor

Skeletal Muscle

Fibrosis

Mitogen-Activated Protein Kinase 3

Mitogen-Activated Protein Kinase 1

31 Citas

The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates Transforming Growth Factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal muscles

Cabello-Verrugio, C., Santander, C., Cofré, C., Acuña, M. J., Melo, F. & Brandan, E. 24 feb 2012 En : Journal of Biological Chemistry. 287, 9, p. 6773-6787 15 p.

Resultado de la investigación: Contribución a la publicación › Article

Low Density Lipoprotein Receptor-Related Protein-1

Decorin

Leucine

Transforming Growth Factor beta

Muscle

2011

33 Citas

Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type β receptors and the JNK pathway

Cabello-Verrugio, C., Córdova, G., Vial, C., Zúñiga, L. M. & Brandan, E. 1 feb 2011 En : Cellular Signalling. 23, 2, p. 449-457 9 p.

Resultado de la investigación: Contribución a la publicación › Article

Connective Tissue Growth Factor

Transforming Growth Factor beta Receptors

MAP Kinase Signaling System

Transcriptional Activation

Transforming Growth Factor beta

51 Citas

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

Morales, M. G., Cabello-Verrugio, C., Santander, C., Cabrera, D., Goldschmeding, R. & Brandan, E. dic 2011 En : Journal of Pathology. 225, 4, p. 490-501 12 p.

Resultado de la investigación: Contribución a la publicación › Article

Skeletal Muscle

Muscles

Muscular Dystrophies

Phenotype

Cicatrix

40 Citas

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

Cabello-Verrugio, C., Acuña, M. J., Morales, M. G., Becerra, A., Simon, F. & Brandan, E. 8 jul 2011 En : Biochemical and Biophysical Research Communications. 410, 3, p. 665-670 6 p.

Resultado de la investigación: Contribución a la publicación › Article

NADPH Oxidase

Angiotensin II

Muscle Cells

Muscle

Reactive Oxygen Species

2010

22 Citas

TGF-β receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation

Droguett, R., Cabello-Verrugio, C., Santander, C. & Brandan, E. 1 ene 2010 En : Experimental Cell Research. 316, 15, p. 2487-2503 17 p.

Resultado de la investigación: Contribución a la publicación › Article

Transforming Growth Factor beta Receptors

Transforming Growth Factor beta

Skeletal Muscle

Smad Proteins

Myosins

2008

61 Citas

Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

Vial, C., Zúñiga, L. M., Cabello-Verrugio, C., Cañón, P., Fadic, R. & Brandan, E. may 2008 En : Journal of Cellular Physiology. 215, 2, p. 410-421 12 p.

Resultado de la investigación: Contribución a la publicación › Article

Connective Tissue Growth Factor

Muscle Cells

Muscle

Myoblasts

Skeletal Muscle

2007

86 Citas

A novel modulatory mechanism of transforming growth factor-β signaling through decorin and LRP-1

Cabello-Verrugio, C. & Brandan, E. 29 jun 2007 En : Journal of Biological Chemistry. 282, 26, p. 18842-18850 9 p.

Resultado de la investigación: Contribución a la publicación › Article

Decorin

Transforming Growth Factor beta

Myoblasts

Smad Proteins

Phosphatidylinositol 3-Kinase

2006

87 Citas

Extracellular proteoglycans modify TGF-β bio-availability attenuating its signaling during skeletal muscle differentiation

Droguett, R., Cabello-Verrugio, C., Riquelme, C. & Brandan, E. 1 ago 2006 En : Matrix Biology. 25, 6, p. 332-341 10 p.

Resultado de la investigación: Contribución a la publicación › Article

Decorin

Proteoglycans

Transforming Growth Factor beta

Myoblasts

Skeletal Muscle

39 Citas

The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin

Brandan, E., Retamal, C., Cabello-Verrugio, C. & Marzolo, M. P. 20 oct 2006 En : Journal of Biological Chemistry. 281, 42, p. 31562-31571 10 p.

Resultado de la investigación: Contribución a la publicación › Article

LDL-Receptor Related Proteins

Lipoprotein Receptors

Decorin

LDL Receptors

CHO Cells

2004

83 Citas

Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: Requirement of syndecan-3 for successful fiber formation

Casar, J. C., Cabello-Verrugio, C., Olguin, H., Aldunate, R., Inestrosa, N. C. & Brandan, E. 1 ene 2004 En : Journal of Cell Science. 117, 1, p. 73-84 12 p.

Resultado de la investigación: Contribución a la publicación › Article

Syndecan-3

Heparan Sulfate Proteoglycans

Regeneration

Skeletal Muscle

Muscles

2003

35 Citas

Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation: Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-β

López-Casillas, F., Riquelme, C., Pérez-Kato, Y., Veronica Ponce-Castaneda, M., Osses, N., Esparza-Lopez, J., Gonzalez-Nunez, G., Cabello-Verrugio, C., Mendoza, V., Troncoso, V. & Brandan, E. 3 ene 2003 En : Journal of Biological Chemistry. 278, 1, p. 382-390 9 p.

Resultado de la investigación: Contribución a la publicación › Article

Cloning

Tretinoin

Transforming Growth Factor beta

Muscle

Organism Cloning