CLAUDIO ALEJANDRO CABELLO VERRUGIO &ndash; Resultado de la investigación

2019

Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction

Tapia, P., Gatica, S., Cortés-Rivera, C., Otero, C., Becerra, A., Riedel, C. A., Cabello-Verrugio, C., Kalergis, A. M. & Simon, F., 1 jul 2019, En : Critical Care Medicine. 47, 7, p. 942-950 9 p.

Resultado de la investigación: Article

Septic Shock

Resuscitation

Endothelial Cells

Fibroblasts

Biomarkers

Endothelial Cells Exhibit Two Waves of P-selectin Surface Aggregation Under Endotoxic and Oxidative Conditions

Barrionuevo, N., Gatica, S., Olivares, P., Cabello-Verrugio, C. & Simon, F., 1 dic 2019, En : Protein Journal. 38, 6, p. 667-674 8 p.

Resultado de la investigación: Article

P-Selectin

Oxidative stress

Endothelial cells

Oxidative Stress

Agglomeration

Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival

Vallejos, A., Olivares, P., Gatica, S., Villegas, V., Echeverria, C., Cabello-Verrugio, C. & Simon, F., 1 ene 2019, En : Laboratory Investigation.

Resultado de la investigación: Article

Endotoxemia

Multiple Organ Failure

Tachycardia

Hypotension

Oxidative Stress

Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: a New Target for Sepsis

Gatica, S., Eltit, F., Santibanez, J. F., Varela, D., Cabello-Verrugio, C. & Simon, F., 1 ene 2019, En : Current Molecular Medicine. 19, 8, p. 547-559 13 p.

Resultado de la investigación: Article

Endotoxemia

Multiple Organ Failure

Sepsis

Cytokines

Rats

2 Citas (Scopus)

OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells

Pérez, L., Vallejos, A., Echeverria, C., Varela, D., Cabello-Verrugio, C. & Simon, F., 1 ene 2019, (Accepted/In press) En : Laboratory Investigation.

Resultado de la investigación: Article

HDL Lipoproteins

Endothelial Cells

Cell Membrane

Class E Scavenger Receptors

Respiratory Burst

The p75^NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

Pérez, V., Bermedo-Garcia, F., Zelada, D., Court, F. A., Pérez, M. Á., Fuenzalida, M., Ábrigo, J., Cabello-Verrugio, C., Moya-Alvarado, G., Tapia, J. C., Valenzuela, V., Hetz, C., Bronfman, F. C. & Henríquez, J. P., 12 sep 2019, En : Acta neuropathologica communications. 7, 1, 1 p.

Resultado de la investigación: Article

Acceso abierto

Nerve Growth Factor Receptors

Synaptic Vesicles

Synapses

Neuromuscular Junction

Muscles

TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia

Gatica, S., Villegas, V., Vallejos, A., Olivares, P., Aballai, V., Lagos-Meza, F., Echeverria, C., Cabello-Verrugio, C., Varela, D. & Simon, F., 1 ene 2019, En : Laboratory Investigation.

Resultado de la investigación: Article

Endotoxemia

Kidney

Mortality

Wounds and Injuries

Endotoxins

2018

4 Citas (Scopus)

Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions: An Update on Therapeutic Strategies

Abrigo, J., Simon, F., Cabrera, D., Cordova, G., Trollet, C. & Cabello-Verrugio, C., 1 ene 2018, En : Current protein & peptide science. 19, 12, p. 1189-1200 12 p.

Resultado de la investigación: Article

Transforming Growth Factors

Transforming Growth Factor beta

Muscle

Skeletal Muscle

Atrophy

Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis

Haensgen, H., Albornoz, E., Opazo, M. C., Bugueño, K., Jara Fernández, E. L., Binzberger, R., Rivero-Castillo, T., Venegas Salas, L. F., Simon, F., Cabello-Verrugio, C., Elorza, A. A., Kalergis, A. M., Bueno, S. M. & Riedel, C. A., 6 jun 2018, En : Frontiers in Immunology. 9, JUN, 1257.

Resultado de la investigación: Article

Autoimmune Experimental Encephalomyelitis

T-Lymphocytes

Spleen

Interleukin-10

Eragrostis

Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival

Vallejos, A., Olivares, P., Varela, D., Echeverria, C., Cabello-Verrugio, C., Perez-Leighton, C. & Simon, F., 12 dic 2018, En : Frontiers in Physiology. 9

Resultado de la investigación: Article

2 Citas (Scopus)

Sarcopenia in a mice model of chronic liver disease: role of the ubiquitin–proteasome system and oxidative stress

Campos, F., Abrigo, J., Aguirre, F., Garcés, B., Arrese, M., Karpen, S., Cabrera, D., Andía, M. E., Simon, F. & Cabello-Verrugio, C., 20 jun 2018, (Accepted/In press) En : Pflugers Archiv European Journal of Physiology. p. 1-17 17 p.

Resultado de la investigación: Article

Sarcopenia

Oxidative stress

Liver

Muscle

Liver Diseases

3 Citas (Scopus)

Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation

Cabrera, D., Cabello-Verrugio, C., Solís, N., Martín, D. S., Cofré, C., Pizarro, M., Arab, J. P., Abrigo, J., Campos, F., Irigoyen, B., Carrasco-Avino, G., Bezares, K., Riquelme, V., Riquelme, A., Arrese, M. & Barrera, F., 2 may 2018, En : International Journal of Molecular Sciences. 19, 5, 1339.

Resultado de la investigación: Article

diets

hormones

Hormones

High Fat Diet

Nutrition

1 Cita (Scopus)

TGF-β and Hepatocellular Carcinoma: When A Friend Becomes An Enemy

Arrese, M., Hernandez, A., Astete, L., Estrada, L., Cabello-Verrugio, C. & Cabrera, D., 1 ene 2018, En : Current protein & peptide science. 19, 12, p. 1172-1179 8 p.

Resultado de la investigación: Article

Transforming Growth Factor beta

Hepatocellular Carcinoma

Fibrosis

Cell growth

Neoplasms

6 Citas (Scopus)

TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy

Ábrigo, J., Campos, F., Simon, F., Riedel, C., Cabrera, D., Vilos, C. & Cabello-Verrugio, C., 23 feb 2018, En : Biological Chemistry. 399, 3, p. 253-264 12 p.

Resultado de la investigación: Article

Muscular Atrophy

Transforming Growth Factor beta

Muscle

Skeletal Muscle

Chemical activation

3 Citas (Scopus)

Transforming Growth Factor-Beta Family: Advances in Vascular Function and Signaling

Gatica, S., Cabello-Verrugio, C. & Simon, F., 1 ene 2018, En : Current protein & peptide science. 19, 12, p. 1164-1171 8 p.

Resultado de la investigación: Article

Transforming Growth Factor beta

Blood Vessels

Publications

Health

2017

11 Citas (Scopus)

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Cabrera, D., Wree, A., Povero, D., Solís, N., Hernandez, A., Pizarro, M., Moshage, H., Torres, J., Feldstein, A. E., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. P. & Arrese, M., 1 dic 2017, En : Scientific Reports. 7, 1, 3491.

Resultado de la investigación: Article

Inflammasomes

Fatty Liver

Inflammation

Liver

Hep G2 Cells

7 Citas (Scopus)

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway

Becerra, A., Rojas, M., Vallejos, A., Villegas, V., Pérez, L., Cabello-Verrugio, C. & Simon, F., 1 sep 2017, En : Laboratory Investigation. 97, 9, p. 1033-1046 14 p.

Resultado de la investigación: Article

STAT3 Transcription Factor

Transforming Growth Factors

Fibrosis

Endothelial Cells

Extracellular Matrix Proteins

7 Citas (Scopus)

The complex of PAMAM-OH dendrimer with angiotensin (1–7) prevented the disuse-induced skeletal muscle atrophy in mice

Márquez-Miranda, V., Abrigo, J., Rivera, J. C., Araya-Durán, I., Aravena, J., Simon, F., Pacheco, N., González-Nilo, F. D. & Cabello-Verrugio, C., 13 mar 2017, En : International Journal of Nanomedicine. 12, p. 1985-1999 15 p.

Resultado de la investigación: Article

Dendrimers

Muscular Atrophy

Angiotensins

Muscle

Skeletal Muscle

2016

24 Citas (Scopus)

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Morales, M. G., Abrigo, J., Acuna, M. J., Santos, R. A., Bader, M., Brandan, E., Simon, F., Olguin, H., Cabrera, D. & Cabello-Verrugio, C., 1 abr 2016, En : DMM Disease Models and Mechanisms. 9, 4, p. 441-449 9 p.

Resultado de la investigación: Article

Muscular Atrophy

Muscle

Skeletal Muscle

Immobilization

Renin-Angiotensin System

6 Citas (Scopus)

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

Ábrigo, J., Simon, F., Cabrera, D. & Cabello-Verrugio, C., 1 nov 2016, En : Cellular Physiology and Biochemistry. 40, 1-2, p. 27-38 12 p.

Resultado de la investigación: Article

Muscular Atrophy

Transforming Growth Factor beta

Skeletal Muscle

Myosin Heavy Chains

7-Ala-angiotensin (1-7)

18 Citas (Scopus)

Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1

Cabrera, D., Ruiz, A., Cabello-Verrugio, C., Brandan, E., Estrada, L., Pizarro, M., Solis, N., Torres, J., Barrera, F. & Arrese, M., 1 nov 2016, En : Digestive Diseases and Sciences. 61, 11, p. 3190-3198 9 p.

Resultado de la investigación: Article

Sarcopenia

Somatomedins

Diet

Muscles

Liver

16 Citas (Scopus)

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis

Abrigo, J., Rivera, J. C., Aravena, J., Cabrera, D., Simon, F., Ezquer, F., Ezquer, M. & Cabello-Verrugio, C., 1 ene 2016, En : Oxidative Medicine and Cellular Longevity. 2016, 9047821.

Resultado de la investigación: Article

Oxidative stress

High Fat Diet

Proteasome Endopeptidase Complex

Nutrition

Ubiquitin

23 Citas (Scopus)

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

Abrigo, J., Rivera, J. C., Simon, F., Cabrera, D. & Cabello-Verrugio, C., 1 may 2016, En : Cellular Signalling. 28, 5, p. 366-376 11 p.

Resultado de la investigación: Article

Muscular Atrophy

Transforming Growth Factor beta

Reactive Oxygen Species

Skeletal Muscle

Skeletal Muscle Fibers

2015

35 Citas (Scopus)

Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism

Cisternas, F., Morales, M. G., Meneses, C., Simon, F., Brandan, E., Abrigo, J., Vazquez, Y. & Cabello-Verrugio, C., 2015, En : Clinical Science. 128, 5, p. 307-319 13 p.

Resultado de la investigación: Article

Muscular Atrophy

Angiotensin II

Skeletal Muscle

Myosin Heavy Chains

Skeletal Muscle Fibers

12 Citas (Scopus)

Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells

Abrigo, J., Morales, M. G., Simon, F., Cabrera, D., Capua, G. D. & Cabello-Verrugio, C., 27 jul 2015, En : Phytomedicine. 22, 10, p. 885-893 9 p., 51860.

Resultado de la investigación: Article

Transforming Growth Factor beta

Muscle Cells

Reactive Oxygen Species

Skeletal Muscle

Up-Regulation

26 Citas (Scopus)

Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism

Morales, M. G., Olguín, H., Capua, G. D., Brandan, E., Simon, F. & Cabello-Verrugio, C., 1 ene 2015, En : Clinical Science. 129, 6, p. 461-476 16 p.

Resultado de la investigación: Article

p38 Mitogen-Activated Protein Kinases

Endotoxins

Skeletal Muscle

Lipopolysaccharides

Muscular Atrophy

21 Citas (Scopus)

Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel

Sarmiento, D., Montorfano, I., Cerda, O., Cáceres, M., Becerra, A., Cabello-Verrugio, C., Elorza, A. A., Riedel, C., Tapia, P., Velásquez, L. A., Varela, D. & Simon, F., 1 mar 2015, En : Microvascular Research. 98, p. 187-196 10 p.

Resultado de la investigación: Article

Endothelial cells

Oxidative stress

Ion Channels

Cell Movement

Reactive Oxygen Species

31 Citas (Scopus)

Renin-angiotensin system: An old player with novel functions in skeletal muscle

Cabello-Verrugio, C., Morales, M. G., Rivera, J. C., Cabrera, D. & Simon, F., 1 may 2015, En : Medicinal Research Reviews. 35, 3, p. 437-463 27 p.

Resultado de la investigación: Article

Renin-Angiotensin System

Skeletal Muscle

Insulin Resistance

Fibrosis

Atrophy

12 Citas (Scopus)

Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway

Echeverría, C., Montorfano, I., Cabello-Verrugio, C., Armisén, R., Varela, D. & Simon, F., 1 ene 2015, En : Journal of Hypertension. 33, 5, p. 981-992 12 p.

Resultado de la investigación: Article

Growth Factor Receptors

Transforming Growth Factors

Transforming Growth Factor beta

Fibrosis

Endothelial Cells

27 Citas (Scopus)

The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice

Meneses, C., Morales, M. G., Abrigo, J., Simon, F., Brandan, E. & Cabello-Verrugio, C., 1 sep 2015, En : Pflugers Archiv European Journal of Physiology. 467, 9, p. 1975-1984 10 p., A001.

Resultado de la investigación: Article

Muscular Atrophy

Angiotensins

Angiotensin II

Muscle

Skeletal Muscle

6 Citas (Scopus)

Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies

Cofre, C., Acuña, M. J., Contreras, O., Morales, M. G., Riquelme, C., Cabello-Verrugio, C. & Brandan, E., 1 mar 2015, En : BioFactors. 41, 2, p. 111-120 10 p.

Resultado de la investigación: Article

Muscular Dystrophies

Myoblasts

Skeletal Muscle Fibers

Transforming Growth Factors

Fibroblasts

2014

19 Citas (Scopus)

Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

Cabrera, D., Gutiérrez, J., Cabello-Verrugio, C., Morales, M. G., Mezzano, S., Fadic, R., Casar, J. C., Hancke, J. L. & Brandan, E., 21 mar 2014, En : Skeletal Muscle. 4, 1, 6.

Resultado de la investigación: Article

Inbred mdx Mouse

Cell- and Tissue-Based Therapy

Skeletal Muscle

Fibrosis

Duchenne Muscular Dystrophy

22 Citas (Scopus)

Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2

Echeverría, C., Montorfano, I., Tapia, P., Riedel, C., Cabello-Verrugio, C. & Simon, F., 2014, En : Infection and Immunity. 82, 9, p. 3678-3686 9 p.

Resultado de la investigación: Article

Transforming Growth Factors

Endotoxins

Fibrosis

Endothelial Cells

Smad3 Protein

20 Citas (Scopus)

Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity

Sarmiento, D., Montorfano, I., Cáceres, M., Echeverría, C., Fernández, R., Cabello-Verrugio, C., Cerda, O., Tapia, P. & Simon, F., 1 ene 2014, En : International Journal of Biochemistry and Cell Biology. 55, p. 11-23 13 p.

Resultado de la investigación: Article

NADPH Oxidase

Endothelial cells

Calcium Channels

Endotoxins

Cell Movement

26 Citas (Scopus)

Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity

Echeverría, C., Montorfano, I., Hermosilla, T., Armisén, R., Velásquez, L. A., Cabello-Verrugio, C., Varela, D. & Simon, F., 7 abr 2014, En : PLoS ONE. 9, 4, e94146.

Resultado de la investigación: Article

Endothelial cells

endotoxins

fibrosis

blood vessels

Endotoxins

18 Citas (Scopus)

Expression of the Mas receptor is upregulated in skeletal muscle wasting

Morales, M. G., Abrigo, J., Meneses, C., Cisternas, F., Simon, F. & Cabello-Verrugio, C., 1 ene 2014, En : Histochemistry and Cell Biology. 143, 2, p. 131-141 11 p.

Resultado de la investigación: Article

Angiotensin II

Skeletal Muscle

Lipopolysaccharides

Immobilization

Muscular Atrophy

57 Citas (Scopus)

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-b1 and TGF-b2-dependent pathway

Montorfano, I., Becerra, A., Cerro, R., Echeverría, C., Sáez, E., Morales, M. G., Fernández, R., Cabello-Verrugio, C. & Simon, F., 1 ene 2014, En : Laboratory Investigation. 94, 10, p. 1068-1082 15 p.

Resultado de la investigación: Article

Myofibroblasts

Oxidative Stress

Endothelial Cells

Inflammation

p38 Mitogen-Activated Protein Kinases

81 Citas (Scopus)

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

Acuña, M. J., Pessina, P., Olguin, H., Cabrera, D., Vio, C. P., Bader, M., Muñoz-canoves, P., Santos, R. A., Cabello-verrugio, C. & Brandan, E., 1 mar 2014, En : Human Molecular Genetics. 23, 5, p. 1237-1249 13 p., ddt514.

Resultado de la investigación: Article

Muscle Strength

Transforming Growth Factors

Inbred mdx Mouse

Duchenne Muscular Dystrophy

Muscles

33 Citas (Scopus)

The ang-(1-7)/mas-1 axis attenuates the expression and signalling of TGF-β1 induced by angii in mouse skeletal muscle

Morales, M. G., Ábrigo, J., Meneses, C., Simon, F., Cisternas, F., Rivera, J. C., Vazquez, Y. & Cabello-Verrugio, C., 2014, En : Clinical Science. 127, 4, p. 251-264 14 p.

Resultado de la investigación: Article

Transforming Growth Factors

Angiotensin II

Skeletal Muscle

p38 Mitogen-Activated Protein Kinases

Phosphorylation

2013

45 Citas (Scopus)

Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)

Morales, M. G., Cabrera, D., Céspedes, C., Vio, C. P., Vazquez, Y., Brandan, E. & Cabello-Verrugio, C., 1 jul 2013, En : Cell and Tissue Research. 353, 1, p. 173-187 15 p.

Resultado de la investigación: Article

Connective Tissue Growth Factor

Inbred mdx Mouse

Peptidyl-Dipeptidase A

Skeletal Muscle

Fibrosis

36 Citas (Scopus)

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells

Echeverría, C., Montorfano, I., Sarmiento, D., Becerra, A., Nuñez-Villena, F., Figueroa, X. F., Cabello-Verrugio, C., Elorza, A. A., Riedel, C. & Simon, F., jun 2013, En : Journal of Cellular and Molecular Medicine. 17, 6, p. 800-814 15 p.

Resultado de la investigación: Article

Lipopolysaccharides

Endothelial Cells

Phenotype

Fibrosis

Systemic Inflammatory Response Syndrome

64 Citas (Scopus)

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

Morales, M. G., Gutierrez, J., Cabello-Verrugio, C., Cabrera, D., Lipson, K. E., Goldschmeding, R. & Brandan, E., 1 dic 2013, En : Human Molecular Genetics. 22, 24, p. 4938-4951 14 p., ddt352.

Resultado de la investigación: Article

Inbred mdx Mouse

Cell- and Tissue-Based Therapy

Duchenne Muscular Dystrophy

Muscles

Dystrophin

22 Citas (Scopus)

Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle

Painemal, P., Acuña, M. J., Riquelme, C., Brandan, E. & Cabello-Verrugio, C., jul 2013, En : BioFactors. 39, 4, p. 467-475 9 p.

Resultado de la investigación: Article

Angiotensin Type 2 Receptor

p38 Mitogen-Activated Protein Kinases

Transforming Growth Factor beta

Muscle

Skeletal Muscle

2012

52 Citas (Scopus)

Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells

Morales, M. G., Vazquez, Y., Acuña, M. J., Rivera, J. C., Simon, F., Salas, J. D., Álvarez Ruf, J., Brandan, E. & Cabello-Verrugio, C., 1 nov 2012, En : International Journal of Biochemistry and Cell Biology. 44, 11, p. 1993-2002 10 p.

Resultado de la investigación: Article

Angiotensin II

Transforming Growth Factor beta

Muscle Cells

Muscle

Skeletal Muscle

47 Citas (Scopus)

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

Cabello-Verrugio, C., Morales, M. G., Cabrera, D., Vio, C. P. & Brandan, E., 2012, En : Journal of Cellular and Molecular Medicine. 16, 4, p. 752-764 13 p.

Resultado de la investigación: Article

Angiotensin Type 1 Receptor

Skeletal Muscle

Fibrosis

Mitogen-Activated Protein Kinase 3

Mitogen-Activated Protein Kinase 1

40 Citas (Scopus)

The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates Transforming Growth Factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal muscles

Cabello-Verrugio, C., Santander, C., Cofré, C., Acuña, M. J., Melo, F. & Brandan, E., 24 feb 2012, En : Journal of Biological Chemistry. 287, 9, p. 6773-6787 15 p.

Resultado de la investigación: Article

Low Density Lipoprotein Receptor-Related Protein-1

Decorin

Transforming Growth Factors

Leucine

Muscle

2011

34 Citas (Scopus)

Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type β receptors and the JNK pathway

Cabello-Verrugio, C., Córdova, G., Vial, C., Zúñiga, L. M. & Brandan, E., 1 feb 2011, En : Cellular Signalling. 23, 2, p. 449-457 9 p.

Resultado de la investigación: Article

Connective Tissue Growth Factor

Growth Factor Receptors

MAP Kinase Signaling System

Transforming Growth Factors

Transcriptional Activation

63 Citas (Scopus)

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

Morales, M. G., Cabello-Verrugio, C., Santander, C., Cabrera, D., Goldschmeding, R. & Brandan, E., dic 2011, En : Journal of Pathology. 225, 4, p. 490-501 12 p.

Resultado de la investigación: Article

Skeletal Muscle

Muscles

Muscular Dystrophies

Phenotype

Cicatrix

46 Citas (Scopus)

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

Cabello-Verrugio, C., Acuña, M. J., Morales, M. G., Becerra, A., Simon, F. & Brandan, E., 8 jul 2011, En : Biochemical and Biophysical Research Communications. 410, 3, p. 665-670 6 p.

Resultado de la investigación: Article

NADPH Oxidase

Angiotensin II

Muscle Cells

Muscle

Reactive Oxygen Species

2010

27 Citas (Scopus)

TGF-β receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation

Droguett, R., Cabello-Verrugio, C., Santander, C. & Brandan, E., 1 ene 2010, En : Experimental Cell Research. 316, 15, p. 2487-2503 17 p.

Resultado de la investigación: Article

Growth Factor Receptors

Transforming Growth Factors

Skeletal Muscle

Smad Proteins

Myosins