Wnt signaling involvement in β-amyloid-dependent neurodegeneration

Nibaldo C. Inestrosa, Giancarlo V. De Ferrari, José L. Garrido, Alejandra Alvarez, Gonzalo H. Olivares, María I. Barría, Miguel Bronfman, Marcelo A. Chacón

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-β peptide (Aβ). We have observed that Aβ-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalNeurochemistry International
Volume41
Issue number5
DOIs
Publication statusPublished - 28 Aug 2002

Keywords

  • β-Amyloid
  • Neurodegeneration
  • Wnt signaling

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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