WNT and β-catenin signalling: Diseases and therapies

Randall T. Moon, Aimee D. Kohn, Giancarlo V. De Ferrari, Ajamete Kaykas

Research output: Contribution to journalReview articlepeer-review

1502 Citations (Scopus)

Abstract

WNT signalling has been studied primarily in developing embryos, in which cells respond to WNTs in a context-dependent manner through changes in survival and proliferation, cell fate and movement. But WNTs also have important functions in adults, and aberrant signalling by WNT pathways is linked to a range of diseases, most notably cancer. What is the full range of diseases that involve WNT pathways? Can inhibition of WNT signalling form the basis of an effective therapy for some cancers? Could activation of WNT signalling provide new therapies for other clinical conditions? Finally, on the basis of recent experiments, might WNTs normally participate in self-renewal, proliferation or differentiation of stem cells? If so, altering WNT I signalling might be beneficial to the use of stem cells for therapeutic means.

Original languageEnglish
Pages (from-to)691-701
Number of pages11
JournalNature Reviews Genetics
Volume5
Issue number9
DOIs
Publication statusPublished - 1 Sep 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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