Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa

Pamela Thomson, Loida López-Fernández, Josep Guarro, Javier Capilla

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume89
Issue number1
DOIs
Publication statusPublished - Sep 2017
Externally publishedYes

Keywords

  • Antifungal susceptibility
  • Rhodotorula mucilaginosa
  • Therapy
  • Virulence

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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