Understanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development

Felipe R. Uribe, Valentina P.I. González, Alexis M. Kalergis, Jorge A. Soto, Karen Bohmwald

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Central nervous system (CNS) pathologies are a public health concern, with viral infections one of their principal causes. These viruses are known as neurotropic pathogens, characterized by their ability to infiltrate the CNS and thus interact with various cell populations, inducing several diseases. The immune response elicited by neurotropic viruses in the CNS is commanded mainly by microglia, which, together with other local cells, can secrete inflammatory cytokines to fight the infection. The most relevant neurotropic viruses are adenovirus (AdV), cytomegalovirus (CMV), enterovirus (EV), Epstein–Barr Virus (EBV), herpes simplex virus type 1 (HSV-1), and herpes simplex virus type 2 (HSV-2), lymphocytic choriomeningitis virus (LCMV), and the newly discovered SARS-CoV-2. Several studies have associated a viral infection with systemic lupus erythematosus (SLE) and neuropsychiatric lupus (NPSLE) manifestations. This article will review the knowledge about viral infections, CNS pathologies, and the immune response against them. Also, it allows us to understand the relevance of the different viral proteins in developing neuronal pathologies, SLE and NPSLE.

Original languageEnglish
Article number59
JournalBrain Sciences
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2024

Keywords

  • aseptic meningitis
  • central nervous system
  • encephalitis
  • immune system
  • neurotropic viruses
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • General Neuroscience

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