TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway

Ricardo Armisén, Katherine Marcelain, Felipe Simon, Julio C. Tapia, Jessica Toro, Andrew F.G. Quest, Andrés Stutzin

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalJournal of Cellular Physiology
Volume226
Issue number1
DOIs
Publication statusPublished - Jan 2011

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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