Transposition of IST2 in Thiobacillus ferrooxidans

Reginaldo Cádiz, Leonardo Gaete, Eugenia Jedlicki, James Yates, David S. Holmes, Omar Orellana

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The genome of Thiobacillus ferrooxidans contains at least two different repetitive DNA elements. One of these elements, termed IST2 has been sequenced and shown to exhibit the characteristics of a typical prokaryotic insertion sequence. Furthermore, preliminary evidence has implicated IST2 in genomic rearrangements, although the mechanism of rearrangement, whether by transposition or recombination, has not been established. In this report we provide evidence from detailed restriction enzyme analyses and DNA sequencing data that support a model of transposition, consistent with the notion that IST2 is a mobile insertion sequence.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalMolecular Microbiology
Issue number1
Publication statusPublished - Apr 1994

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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