Transplant tolerance: New insights and strategies for long-term allograft acceptance

Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Alejandra Gleisner, Daniela Sauma, Cinthia Silva, Juan Jose Saez, Sarah Nuñez, Mario Rosemblatt, Maria Rosa Bono

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance.

Original languageEnglish
Article number210506
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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    Ruiz, P., Maldonado, P., Hidalgo, Y., Gleisner, A., Sauma, D., Silva, C., Saez, J. J., Nuñez, S., Rosemblatt, M., & Bono, M. R. (2013). Transplant tolerance: New insights and strategies for long-term allograft acceptance. Clinical and Developmental Immunology, 2013, [210506]. https://doi.org/10.1155/2013/210506