Transfersomes as alternative topical nanodosage forms for the treatment of skin disorders

Pablo Oyarzún, Eduardo Gallardo-Toledo, Javier Morales, Francisco Arriagada

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


Topical drug delivery is a promising approach to treat different skin disorders. However, it remains a challenge mainly due to the nature and rigidity of the nanosystems, which limit deep skin penetration, and the unsuccessful demonstration of clinical benefits; greater penetration by itself, does not ensure pharmacological success. In this context, transfersomes have appeared as promising nanosystems; deformability, their unique characteristic, allows them to pass through the epidermal microenvironment, improving the skin drug delivery. This review focuses on the comparison of transfersomes with other nanosystems (e.g., liposomes), discusses recent therapeutic applications for the topical treatment of different skin disorders and highlights the need for further studies to demonstrate significant clinical benefits of transfersomes compared with conventional therapies.

Original languageEnglish
Pages (from-to)2465-2489
Number of pages25
Issue number27
Publication statusPublished - Nov 2021
Externally publishedYes


  • deformability
  • nanosystem
  • skin diseases
  • topical drug delivery
  • transfersomes
  • ultradeformable liposomes

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • General Materials Science


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