Towards an intrinsic nucleofugality scale: The leaving group (LG) ability in CH3LG model system

P. Jaramillo, L. R. Domingo, P. Pérez

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

For an important class of organic reactions in which a fragment of the reactants, the leaving group (LG) or nucleofuge (Z), is detached of the substrate bearing the bonding electron pair, the global electrophilicity index of the CH3LG system is proposed as a reliable descriptor of the intrinsic nucleofugality of the LG. The model is illustrated by ranking within a unique relative scale, the LG ability of 28 functional groups commonly involved in substitution and elimination reactions in organic chemistry.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalChemical Physics Letters
Volume420
Issue number1-3
DOIs
Publication statusPublished - 10 Mar 2006

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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