Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health

Maria C. Opazo; Juan Carlos Rivera; Pablo A. Gonzalez; Susan M. Bueno; Alexis M. Kalergis; Claudia A. Riedel

doi:10.3389/fendo.2021.679002

Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health

Maria C. Opazo, Juan Carlos Rivera, Pablo A. Gonzalez, Susan M. Bueno, Alexis M. Kalergis, Claudia A. Riedel

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring.

Original language	English
Article number	679002
Journal	Frontiers in Endocrinology
Volume	12
DOIs	https://doi.org/10.3389/fendo.2021.679002
Publication status	Published - 14 Oct 2021

Keywords

breastfeeding
congenital hypothyroid women
genetic counseling
iodine
offspring
pregnancy
thyroid hormones

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fendo.2021.679002

Cite this

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title = "Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring{\textquoteright}s Health",

abstract = "Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring.",

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year = "2021",

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doi = "10.3389/fendo.2021.679002",

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volume = "12",

journal = "Frontiers in Endocrinology",

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T1 - Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism

T2 - Implications for the Offspring’s Health

AU - Opazo, Maria C.

AU - Rivera, Juan Carlos

AU - Gonzalez, Pablo A.

AU - Bueno, Susan M.

AU - Kalergis, Alexis M.

AU - Riedel, Claudia A.

PY - 2021/10/14

Y1 - 2021/10/14

N2 - Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring.

AB - Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring.

KW - breastfeeding

KW - congenital hypothyroid women

KW - genetic counseling

KW - iodine

KW - offspring

KW - pregnancy

KW - thyroid hormones

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DO - 10.3389/fendo.2021.679002

M3 - Review article

AN - SCOPUS:85118269507

SN - 1664-2392

VL - 12

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

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Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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