Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health

Maria C. Opazo, Juan Carlos Rivera, Pablo A. Gonzalez, Susan M. Bueno, Alexis M. Kalergis, Claudia A. Riedel

Research output: Contribution to journalReview articlepeer-review

Abstract

Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring.

Original languageEnglish
Article number679002
JournalFrontiers in Endocrinology
Volume12
DOIs
Publication statusPublished - 14 Oct 2021

Keywords

  • breastfeeding
  • congenital hypothyroid women
  • genetic counseling
  • iodine
  • offspring
  • pregnancy
  • thyroid hormones

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Fingerprint

Dive into the research topics of 'Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health'. Together they form a unique fingerprint.

Cite this