Theoretical and experimental approaches aimed at drug design targeting neurodegenerative diseases

Samuel Morales-Navarro, Luis Prent-Peñaloza, Yeray A.Rodríguez Núñez, Laura Sánchez-Aros, Oscar Forero-Doria, Wendy González, Nuria E. Campilllo, Miguel Reyes-Parada, Ana Martínez, David Ramírez

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


In recent years, green chemistry has been strengthening, showing how basic and applied sciences advance globally, protecting the environment and human health. A clear example of this evolution is the synergy that now exists between theoretical and computational methods to design new drugs in the most efficient possible way, using the minimum of reagents and obtaining the maximum yield. The development of compounds with potential therapeutic activity against multiple targets associated with neurodegenerative diseases/disorders (NDD) such as Alzheimer's disease is a hot topic in medical chemistry, where different scientists from various disciplines collaborate to find safe, active, and effective drugs. NDD are a public health problem, affecting mainly the population over 60 years old. To generate significant progress in the pharmacological treatment of NDD, it is necessary to employ different experimental strategies of green chemistry, medical chemistry, and molecular biology, coupled with computational and theoretical approaches such as molecular simulations and chemoinformatics, all framed in the rational drug design targeting NDD. Here, we review how green chemistry and computational approaches have been used to develop new compounds with the potential application against NDD, as well as the challenges and new directions of the drug development multidisciplinary process.

Original languageEnglish
Article number940
Issue number12
Publication statusPublished - 1 Dec 2019


  • Chemoinformatics
  • Drug design
  • Green chemistry
  • Medical chemistry
  • Molecular modeling
  • Neurodegenerative diseases

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Process Chemistry and Technology


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