Theoretical analysis of substituted diels - Alder reagents to determine

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5 Citations (Scopus)

Abstract

The non-polar character of Diels-Alder (DA) reactions using 1- and 2-substituted butadienes and ethylene is discussed. Linear correlations between variations in the energy barrier and the electrophilicity index have been obtained. The charge transfer (CT) process in the cycloaddition reactions depends on the substitution pattern on almost all ethylene reagents. The current work stresses that a polar DA reaction will occur when only the ethylene is substituted by electronwithdrawing (EW) groups increasing its electrophilicity or when both DA reagents are being activated by EW and electron-releasing (ER) groups, enhancing their electrophilic and nucleophilic nature.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalLetters in Organic Chemistry
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Electrophilicity
  • Non polar diels-alder reactions
  • Nucleophilicity
  • Polar diels-alder reactions
  • Substituted butadienes and ethylenes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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