The ups and downs of Wnt signaling in prevalent neurological disorders

G. V. De Ferrari, R. T. Moon

Research output: Contribution to journalReview articlepeer-review

166 Citations (Scopus)

Abstract

In order to function properly, the brain must be wired correctly during critical periods in early development. Mistakes in this process are hypothesized to occur in disorders like autism and schizophrenia. Later in life, signaling pathways are essential in maintaining proper communication between neuronal and non-neuronal cells, and disrupting this balance may result in disorders like Alzheimer's disease. The Wnt/β-catenin pathway has a well-established role in cancer. Here, we review recent evidence showing the involvement of Wnt/β-catenin signaling in neurodevelopment as well as in neurodegenerative diseases. We suggest that the onset/development of such pathological conditions may involve the additive effect of genetic variation within Wnt signaling components and of molecules that modulate the activity of this signaling cascade.

Original languageEnglish
Pages (from-to)7545-7553
Number of pages9
JournalOncogene
Volume25
Issue number57
DOIs
Publication statusPublished - 4 Dec 2006

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Autism
  • Genetic variation
  • Schizophrenia
  • Wnt signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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