The presence in mice chronically treated with morphine of a substance (S) that modifies morphine responses

F. Huidobro, H. Miranda

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A principle that shortens and reduces the intensity of the abstinence syndrome to morphine in white mice was obtained from whole mouse extracts and from urine of mice chronically intoxicated with morphine pellets. Furthermore, a substance that prolongs morphine analgesia was found in extracts from mice implanted with pellets of morphine. At present, it is not known whether both principles are the same. Procedures followed to obtain the indicated principle(s) are described.

Original languageEnglish
Pages (from-to)1099-1105
Number of pages7
JournalBiochemical Pharmacology
Volume17
Issue number6
Publication statusPublished - Jun 1968

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry

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